Identification method, correction method and alarm method for turbidimetry abnormal reaction curve

An abnormal response and response curve technology, applied in the medical field, can solve problems such as bubble generation, identification, and failure to consider the abnormal response curve of whole blood C-reactive protein, so as to achieve the effect of improving accuracy

Active Publication Date: 2016-04-06
SHENZHEN MINDRAY BIO MEDICAL ELECTRONICS CO LTD
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Problems solved by technology

[0004] Since the blood cells contained in whole blood may affect the scattering or absorption of light, in order to remove the interference of blood cells on the measurement of C-reactive protein, it is necessary to add reagents to dissolve blood cells to remove interference, and to measure C-reactive protein also need to add reagents to make the antigen antibody Generate a reaction; air bubbles may be generated during the transport of reagents to the sample cuvette. When bubbles appear in the sample cuvette, the instrument will detect many interference signals, which will affect the accuracy of C-reactive protein detection.
[0005] Unfortunately, for the measurement of whole blood C-reactive protein, the existing technology does not consider the identification of abnormal reaction curve of whole blood C-reactive protein, and then take corresponding treatment

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  • Identification method, correction method and alarm method for turbidimetry abnormal reaction curve
  • Identification method, correction method and alarm method for turbidimetry abnormal reaction curve
  • Identification method, correction method and alarm method for turbidimetry abnormal reaction curve

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example 1

[0141] Whole blood C-reactive protein detection equipment is the BC-5390 blood cell analyzer produced by Shenzhen Mindray Biomedical Electronics Co., Ltd. The first test of C-reactive protein detection is performed on a patient's blood sample. The response curve is as follows Figure 6A As shown, the corresponding C-reactive protein is: 4.4mg / L.

[0142] According to the identification method of the embodiment of the present invention, the abnormal identification of the reaction curve is carried out, wherein, the identification of the abnormal point of the first order difference is as follows: Figure 6C As shown, the second-order difference outlier identification is as follows Figure 6D As shown, the third-order difference outlier identification is as follows Figure 6E As shown, the ratio of abnormal points Ratio_A identified by the first-order difference, second-order difference, and third-order difference is 48.18%.

[0143] In this instrument, the second threshold ψ is...

example 2

[0148] Whole blood C-reactive protein detection equipment is the BC-5390 blood cell analyzer produced by Shenzhen Mindray Biomedical Electronics Co., Ltd. The first test of C-reactive protein detection is performed on a patient's blood sample. The response curve is as follows Figure 7A As shown, the corresponding C-reactive protein is: 3.5mg / L.

[0149] According to the identification method of the embodiment of the present invention, the abnormal identification of the reaction curve is carried out, wherein, the identification of the abnormal point of the first order difference is as follows: Figure 7C As shown, the second-order difference outlier identification is as follows Figure 7D As shown, the third-order difference outlier identification is as follows Figure 7E As shown, the ratio of abnormal points Ratio_A identified by the first-order difference, second-order difference, and third-order difference is 59.12%.

[0150] In this instrument, the second threshold ψ is...

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Abstract

The present invention provides an identification method, a correction method and an alarm method for a turbidimetry abnormal reaction curve. The identification method comprises: acquiring an original reaction curve; and identifying whether the abnormal point exists on the original reaction curve. With the embodiments of the present invention, the abnormal point identifying and alarming is innovatively performed on the turbidimetry reaction curve, the condition that the data possibly being subjected to the abnormal reaction is adopted as the detection result without the treatment is avoided, and the detection accuracy can be easily improved; and the identified abnormal point is corrected, such that the significantly-abnormal reaction curve can be well made up, and the detection accuracy is substantially improved.

Description

technical field [0001] The invention relates to the field of medical technology, in particular to a method for identifying, correcting and alarming abnormal reaction curves of turbidimetry. Background technique [0002] C-reactive protein (C-reactive protein, CRP) is one of the acute phase reaction proteins. In clinical practice, it is often necessary to test the concentration of C-reactive protein. [0003] At present, the industry measures the concentration of C-reactive protein mainly to measure the concentration of C-reactive protein in serum. Japanese Patent No. 11575 / 1983 discloses an immunoassay method, which utilizes the antigen or antibody on the insoluble substance and the corresponding antigen on the sample. Antibodies or antigens combine to form agglutinates, and then use light waves with wavelengths between 600nm and 2400nm to irradiate the agglutinates, and finally obtain the parameters of the antigens by analyzing the degree of light absorption or scattering. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/82G01N33/68
Inventor 郑文波叶波祁欢
Owner SHENZHEN MINDRAY BIO MEDICAL ELECTRONICS CO LTD
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