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Apparatus and method for calibrating acoustic, desynchronized neural stimulation

A kind of equipment and neuron technology, applied in the field of desynchronized neurostimulation, can solve the problems of poor test results, testing, and inability to stimulate point development, etc.

Active Publication Date: 2019-08-02
GRETAP AG
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Time-consuming experiments do not guarantee the ideal effect of non-invasive CR treatment, because on the one hand, it is not possible to systematically develop and test all possible stimulation points in the brain, and on the other hand, the long-term examination makes the patient Stressed, which naturally affects patient compliance and worsens test results

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  • Apparatus and method for calibrating acoustic, desynchronized neural stimulation
  • Apparatus and method for calibrating acoustic, desynchronized neural stimulation
  • Apparatus and method for calibrating acoustic, desynchronized neural stimulation

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[0082] Example: by parameter N stim =100, ΔF=500Hz, F 下限 =100Hz, F 上限 = 13000Hz, at main frequency Stimulus frequency F stim = 1.5Hz and thus the stimulation period T stim = 0.666s. Therefore, as the check duration gets minute. If on the contrary only N stim = 50 number of stimulation cycles to scan the window width ΔF = 500 Hz, which results in a poorer selectivity between frequency intervals with or without entrainment, but the detection time is halved: T ges = 14.3 minutes.

[0083] main frequency In the lower interval of the so-called Delta-band (1-4 Hz). If the dominant frequency is higher, significantly shorter detection times are obtained. For example, for (and other identical parameters) yields for N stim T=100 ges = 14.3 minutes and for N stim T=50 ges = 7.2 minutes. If the dominant frequency is on the Theta-band (5-8Hz) and is e.g. then pass Get the corresponding detection time: for N stim T=100 ges = 7.2 minutes and for N stim T=50 ges...

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Abstract

The invention relates to a device for stimulating neurons, comprising: a stimulation unit for applying pulse-like tones; a measuring unit for receiving a measuring signal reflecting the neural activity of the stimulated neuron; for controlling A control and analysis unit that stimulates the unit and analyzes the measurement signal, the control and analysis unit is designed such that it applies a first pulse sequence with different pitch heights, and selects the measurement signal received as a response to the first pulse sequence finding at least one first pitch interval or pitch in which there is phase synchronization between the pulse train and the neural activity, manipulating the stimulation unit to apply two phase shifted second pulse trains of oppositely varying pitch, and according to At least one first pitch interval or pitch selects an initial pitch value of the second pulse sequence, and a second pitch interval or pitch in which the amplitude of the neural activity is smallest is selected based on the response.

Description

technical field [0001] The invention relates to a device and a method for calibrating acoustically desynchronized nerve stimulation. Background technique [0002] In patients with neurological diseases such as tinnitus, depression, obsessive-compulsive disorder, ADHS or schizophrenia, populations of nerve cells in specific regions of the brain are pathologically triggered, eg hypersynchronously triggered. In this case, a large number of nerves form synchronous action potentials, which means that the nerves involved fire excessively synchronously. In contrast, in healthy people the nerves in this area of ​​the brain fire in other ways, for example in unrelated ways. [0003] Acoustic coordination reset (CR)-stimulation was developed for the treatment of chronic subjective tinnitus, which purposely resists pathologically synchronized neural triggers (see P.A. Tass, I. Adamchic, H.-J. Freund, T. von Stackelberg, "Counteracting tinnitus by acoustic coordinated resetneuromodula...

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61M21/00
CPCA61B5/12A61B5/4836A61F11/00A61M21/00A61M2021/0027A61M2230/10A61B5/38H04R25/75
Inventor 彼得·亚历山大·塔斯
Owner GRETAP AG