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Applications of Trigonoliimines C in preparation of anti-fungal medicines for human bodies

An antifungal and drug technology, applied in the direction of antifungal agents, active ingredients of heterocyclic compounds, etc., can solve the problems of strong accumulation of toxicity, irritation, dizziness, allergies, etc. Effect

Inactive Publication Date: 2016-05-04
ZIBO DINGLI PATENT INFORMATION CONSULTING CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Pathogenic fungi seriously threaten human health and life. Antifungal drugs have been widely used as routine medications. Currently, clinically used antibacterial agents (such as ketoconazole, amikacin, gentamycin, vigorconazole, Itraconazole, terbinafine, amphotericin, fluconazole, etc.) have good curative effect on skin and superficial infection, but these antibacterial drugs have strong cumulative toxicity, often causing liver and kidney damage, digestive tract Stimulation, dizziness, allergies, etc., so looking for new antifungal drugs with a unique mechanism of action has become one of the hot spots in drug research and development today

Method used

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  • Applications of Trigonoliimines C in preparation of anti-fungal medicines for human bodies
  • Applications of Trigonoliimines C in preparation of anti-fungal medicines for human bodies
  • Applications of Trigonoliimines C in preparation of anti-fungal medicines for human bodies

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Embodiment 1: the preparation of the compound TrigonoliiminesC tablet involved in the present invention:

[0015] Take 5 grams of compound Trigonoliimines C, add 195 grams of dextrin, mix well, and make 1000 tablets by conventional compression.

Embodiment 2

[0016] Embodiment 2: the preparation of the compound TrigonoliiminesC capsule involved in the present invention:

[0017] Get 5 grams of compound TrigonoliiminesC, add 195 grams of starch, mix evenly, and make 1000 capsules.

[0018] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example 1

[0019] Experimental example 1: Anti-fungal activity of TrigonoliiminesC

[0020] The anti-fungal activity experiment against human body adopts the method of concentration dilution, and each determination is repeated three times. The test pathogens include Trichomonas rubrum, Microsporum lanoides and Trichomonas clumps, and the concentration of bacteria solution is 105 / mL. The initial concentration of TrigonoliiminesC was 50.0 μg / mL (5% dimethyl sulfoxide DMSO), and it was serially diluted to 0.098 μg / mL. Equal volumes of bacteria liquid and test samples were mixed and cultured in a 96-well plate, and the culture temperature of human fungi was respectively 28°C, observe after 24 hours of incubation time, if no colonies are found, it is the lowest anti-human fungal concentration of the sample, that is, the MIC value. The positive control of this experiment is ketoconazole, and the results of TrigonoliiminesC against human fungi are shown in Table 1.

[0021] Table 1 Trigonoliim...

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PUM

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Abstract

The invention relates to applications of Trigonoliimines C in preparation of anti-fungal medicines for human bodies and belongs to the field of medicines. The Trigonoliimines C has strong functions of inhibiting trichophyton rubrum, microsporum lanosum or trichophyton tonsurans, and therefore the Trigonoliimines C can be adopted as an anti-fungal compound for human bodies and is expected to be applied in preparation of related medicines.

Description

technical field [0001] The present invention relates to a new application of compound Trigonoliimines C, in particular to the application of Trigonoliimines C in the preparation of antifungal drugs for human body. Background technique [0002] Pathogenic fungi seriously threaten human health and life. Antifungal drugs have been widely used as routine medications. Currently, clinically used antibacterial agents (such as ketoconazole, amikacin, gentamycin, vigorconazole, Itraconazole, terbinafine, amphotericin, fluconazole, etc.) have good curative effect on skin and superficial infection, but these antibacterial drugs have strong cumulative toxicity, often causing liver and kidney damage, digestive tract Stimulation, dizziness, allergies, etc., so looking for new antifungal drugs with unique mechanism of action has become one of the hot spots in drug research and development today. [0003] The compound Trigonoliimines C involved in the present invention is a new compound pu...

Claims

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Application Information

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IPC IPC(8): A61K31/55A61P31/10
CPCA61K31/55
Inventor 田丽华
Owner ZIBO DINGLI PATENT INFORMATION CONSULTING CO LTD
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