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Kit for detecting bacteria DNAs in faeces and application thereof in colorectal cancer diagnosis

A kit and colorectal cancer technology, applied in the field of disease diagnosis, can solve problems such as insufficient specificity

Inactive Publication Date: 2016-05-11
RENJI HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

4) CA50 exists in the cell membrane in the form of lipid or lipoprotein binding. It belongs to the glycosphingolipid marker and is a marker of pancreatic and colorectal cancer. The specificity is not enough

Method used

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  • Kit for detecting bacteria DNAs in faeces and application thereof in colorectal cancer diagnosis
  • Kit for detecting bacteria DNAs in faeces and application thereof in colorectal cancer diagnosis
  • Kit for detecting bacteria DNAs in faeces and application thereof in colorectal cancer diagnosis

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Embodiment Construction

[0032] The present invention will be further described below in conjunction with the accompanying drawings and embodiments.

[0033] 1. Patient and tissue samples

[0034] 1) Population A: Stool samples from patients who underwent digital colonoscopy and colorectal cancer surgery from January 1, 2012 to July 30, 2012 at Renji Hospital affiliated to Shanghai Jiaotong University School of Medicine.

[0035] The inclusion criteria are:

[0036] (1) Age ≥ 50 years old;

[0037] (2) Have a normal colonic motility rhythm, and the frequency of defecation is no more than twice a day, and no less than once a day;

[0038](3) Colonoscopy was performed by experienced doctors in accordance with standard specifications, and there was sufficient time to withdraw the colonoscopy.

[0039] The exclusion criteria are:

[0040] (1) Previous history of colorectal adenoma, colorectal cancer, irritable bowel syndrome (IBS), ulcerative colitis (UC) or Crohn's disease (CD);

[0041] (2) Previou...

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Abstract

The invention discloses a kit for detecting bacteria DNAs in faeces and the application thereof in colorectal cancer screening, diagnosis or auxiliary diagnosis. Bacteria DNAs in faeces are extracted and sequenced to obtain the species and abundance of bacteria, and colorectal cancer diagnosis is conducted based on the abundance of various bacteria. Compared with existing noninvasive colorectal cancer screen methods which have already been used clinically or for patent application, the kit has the advantages that the kit is completely noninvasive, colorectal cancer can be predicted and diagnosed more accurately, and the ROC area under the curve can be as high as 0.994.

Description

technical field [0001] The invention relates to the field of disease diagnosis, in particular to a kit for detecting bacterial DNA in feces and its application in screening, diagnosis or auxiliary diagnosis of colorectal cancer. Background technique [0002] Colorectal cancer ranks third in the incidence of all tumors. The current diagnosis of colorectal cancer relies on colonoscopy biopsy. However, colonoscopy biopsy is an invasive examination and cannot be used for large-scale population screening. An ideal tumor screening index should have high sensitivity and specificity, and at the same time be as non-invasive as possible. Research progress in recent years suggests that there are significant differences in the distribution of intestinal flora between patients with colorectal cancer and normal healthy people, and intestinal flora may be involved in the occurrence and development of colorectal cancer. If only the feces of the subjects are analyzed, it can be determined...

Claims

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Application Information

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IPC IPC(8): C12Q1/68
CPCC12Q1/6869C12Q2531/113C12Q2537/165
Inventor 房静远许杰艾罗燕
Owner RENJI HOSPITAL AFFILIATED TO SHANGHAI JIAO TONG UNIV SCHOOL OF MEDICINE
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