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Application of antitussive and antiasthmatic tablets containing bulbophyllum in preparation of drugs for inhibiting proliferation of human tongue cancer cells TCA 8113

A technology of TCA8113 and human tongue cancer cells, which is applied in the field of preparation of Lvji Kechuan Tablets, can solve the problems of backwardness, many impurities, and affecting clinical application.

Inactive Publication Date: 2016-06-08
JINAN XINSHIDAI MEDICINE SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] In the prior art, there is no report on the application of Lvjikechuan Tablets in the preparation of drugs for inhibiting the proliferation of human tongue cancer cell TCA8113 cells, and there is no report on the use of supercritical extraction in the extraction and preparation of Lvjikechuan Tablets. However, the traditional method of decocting in water and ethanol reflux extraction has rough and backward technology and many impurities, which leads to excessive dosage for patients and is inconvenient to take, which seriously affects the clinical application of this product.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] Take 200g of Chrysanthemum splendens, 200g of Chicken Yateng, 100g of Gonggongmu, 100g of Tongguanteng, 100g of Baiji, 100g of Polygonum cuspidatum, 100g of Speranthema spp., and 100g of Polygonatum, and add them to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer to the total extraction solvent is 5%, the extraction pressure is 25MPa, the temperature is 40°C, and the CO 2 The flow rate is 2ml / g crude drug·min, the extraction time is 750min, and the supercritical extract is obtained. The supercritical extract is added to starch and 70% ethanol to make granules, dried, and pressed into tablets to make 200 tablets, each weighing 0.50g.

[0025] After testing, the content of emodin in the finished product is 3.28mg / tablet.

Embodiment 2

[0027] Take 200g of Chrysanthemum splendens, 200g of Chicken Yateng, 100g of Gonggongmu, 100g of Tongguanteng, 100g of Baiji, 100g of Polygonum cuspidatum, 100g of Speranthema spp., and 100g of Polygonatum, and add them to CO 2 In a supercritical extractor, ethanol is used as an entrainer, and the entrainer accounts for 4% by volume of the total extraction solvent. The extraction pressure is 15MPa, the temperature is 30°C, and the CO 2 The flow rate is 1ml / g crude drug·min, the extraction time is 900min, and the supercritical extract is obtained. The supercritical extract is added to starch and 70% ethanol to make granules, dried, and pressed into tablets to make 200 tablets, each weighing 0.50g.

[0028] After testing, the content of emodin in the finished product is 1.65mg / tablet.

Embodiment 3

[0030] Take 200g of Chrysanthemum splendens, 200g of Chicken Yateng, 100g of Gonggongmu, 100g of Tongguanteng, 100g of Baiji, 100g of Polygonum cuspidatum, 100g of Speranthema spp., and 100g of Polygonatum, and add them to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 6%, the extraction pressure is 30MPa, the temperature is 60°C, and the CO 2 The flow rate is 3ml / g crude drug·min, the extraction time is 800min, and the supercritical extract is obtained. The supercritical extract is added to starch and 70% ethanol to make granules, dried, and pressed into tablets to make 200 tablets, each weighing 0.50g.

[0031] After testing, the content of emodin in the finished product is 2.08mg / tablet.

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Abstract

The invention belongs to the technical field of traditional Chinese medicines and particularly relates to an application of antitussive and antiasthmatic tablets containing bulbophyllum in preparation of drugs for inhibiting proliferation of human tongue cancer cells TCA 8113 as well as a preparation method of the antitussive and antiasthmatic tablets containing bulbophyllum. The antitussive and antiasthmatic tablets containing bulbophyllum are prepared from raw material medicines including 200 g of bulbophyllum, 200 g of Chinese fevervine herbs, 100 g of leatherleaf mahonia stems, 100 g of marsdenia tenacissima, 100 g of common bletilla pseudobulb, 100 g of giant knotweed rhizomes, 100 g of garden balsam stems and 100 g of manyflower solomonseal rhizomes. The antitussive and antiasthmatic tablets containing bulbophyllum are prepared through supercritical extraction, so that the content of rheum emodin is greatly increased.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicines, and in particular relates to the application of Lvjikechuan Tablets in the preparation of drugs for inhibiting the proliferation of human tongue cancer cell TCA8113 cells and the preparation method of Lvjikechuan Tablets. Background technique [0002] The standard number of Lvji Kechuan Granules is WS-10616 (ZD-0616)-2002, which is recorded in the National Compilation of Chinese Patent Medicine Standards Internal Medicine Pulmonary System (II) Volume. Made from 200g of Chlorina striata 200g, 200g of Jiyateng, 100g of Gongluomu, 100g of Tongguanteng, 100g of Baiji, 100g of Polygonum cuspidatum, 100g of Speranthema japonicus, and 100g of Huangjing. It is used for cough, hot flashes and night sweats caused by heat-dryness invading the lungs. [0003] In the prior art, there is no report on the application of Lvjikechuan Tablets in the preparation of drugs for inhibiting the pr...

Claims

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Application Information

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IPC IPC(8): A61K36/898A61K9/20A61K47/36A61P35/00
CPCA61K36/898A61K9/2059A61K36/185A61K36/27A61K36/29A61K36/47A61K36/704A61K36/74A61K36/8969A61K2236/37A61K2300/00
Inventor 刘芳
Owner JINAN XINSHIDAI MEDICINE SCI & TECH
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