Micro-flow control device and method for controlling liquid flow

A microfluidic device and technology for controlling fluids, which are applied in fluid controllers, chemical instruments and methods, and determination/inspection of microorganisms, and can solve problems such as adverse effects on equipment

Active Publication Date: 2016-06-15
STAR ARRAY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In the flow path, the presence of these air bubbles may adversely affect the equipment using the flow path

Method used

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  • Micro-flow control device and method for controlling liquid flow
  • Micro-flow control device and method for controlling liquid flow
  • Micro-flow control device and method for controlling liquid flow

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Embodiment Construction

[0049] According to the first embodiment of the present invention, Figure 1a and 2 An isometric view and a side cross-sectional view of the microfluidic device 100 are depicted, respectively. The microfluidic device 100 comprises a component 102 (with a base), a cover 106 and a vacuum generator 108 comprising first and second vacuum generators 1081 , 1082 .

[0050] The first and second vacuum generators 1081 , 1082 are in turn coupled to a single common vacuum source 104 . In particular, said component 102 is a microtiter plate, which will be referred to below. Figure 1bAn enlarged isometric view of the microtiter plate 102 and the cover 106 is depicted in FIG. The microtiter plate 102 can be formed from suitable materials, including polydimethylsiloxane (PDMS), plastic, glass, metal, ceramic, and the like. In this embodiment, the microtiter plate 102 is realized in the form of a sheet. The base and lid 106 are similar in shape and size, more specifically substantially ...

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Abstract

The invention discloses a micro-flow control device (100) for detecting and analyzing diseases. The micro-flow control device (100) comprises a component (102) with at least one hole (110) on a substrate. The at least one hole is in fluid communication with an adjacent space (112). The space is in fluid communication with at least one channel (114,118); and a vacuum generating device (108) which is coupled with the at least one channel. The vacuum generating device is configured for respectively generating a first absolute pressure and a second absolute pressure at the first area and the second area of the micro-flow control device, wherein a random one in the first absolute pressure and the second absolute pressure is lower than atmosphere, wherein the first absolute pressure is higher than the second absolute pressure. Therefore a pressure difference is generated between the first area and the second area of the micro-flow control device for controlling flow speed of the fluid through the space in the device, thereby gradually filling at least one hole and / or promoting a random material which is placed in the at least one hole. Controlling of the fluid flow also prevents crossed pollution of a specific organism and / or chemical substance which is preloaded in the hole. The invention further discloses a related thermal circulating instrument and a method thereof.

Description

technical field [0001] The invention relates to a microfluidic device and a method for controlling its fluid flow. It also relates to a thermocycler comprising said microfluidic device. Background technique [0002] Microplates containing arrays of wells (also called microtiter plates) have been widely used in the field of biology or chemistry, where they can be used to perform a variety of tests involving chemical and biological samples. For example, different pairs of polymerase chain reaction (PCR) primers can be preloaded into different wells of a microplate for simultaneous amplification of target nucleic acid molecules in a given sample. In addition, well arrays can be used for other types of assays, such as cell or antibody assays. [0003] In accordance with recent developments in high-throughput assays, the number of wells in such microplate configurations has increased from previously less than one hundred to often several thousand or more, which in turn leads to...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01L3/00
CPCB01L3/5027B01L3/50273B01L2200/0684B01L2200/141B01L2400/049B01L3/567B01L2200/0642B01L2300/04B01L2300/14B01L2400/06C12Q1/6806
Inventor 龚海庆
Owner STAR ARRAY
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