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Rheum officinale, berberine hydrochloride and scutellaria baicalensis granules and preparation method thereof

A technology of granules and rhubarb, applied in the field of Sanhuang granules and their preparation, can solve the problems of difficult to obtain clear solution, poor resolubility of granules, low stability of granules, etc., and achieves rapid dissolution and simple preparation method. , fast-acting effect

Inactive Publication Date: 2016-07-06
HAINAN HULUWA PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Existing Sanhuang Tablets and Sanhuang Capsules have the advantage of being easy to store, but it is not convenient enough for some patients with swallowing difficulties (such as children), so it is important to prepare Sanhuang Tablets or Sanhuang Capsules into easily soluble granules. significance
However, the commercially available Sanhuang Granules mainly have the following two problems: (1) the resolubility of the granules is not good, and it is not easy to obtain a clear solution; (2) compared with tablets, the stability of the granules is lower much more

Method used

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  • Rheum officinale, berberine hydrochloride and scutellaria baicalensis granules and preparation method thereof
  • Rheum officinale, berberine hydrochloride and scutellaria baicalensis granules and preparation method thereof
  • Rheum officinale, berberine hydrochloride and scutellaria baicalensis granules and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Rhubarb 300g Berberine hydrochloride 5g Scutellaria baicalensis 20g

[0027] Glucose 550g Microcrystalline Cellulose 260g Magnesium Stearate 1g

[0028] (1) Scutellaria baicalensis was extracted three times, adding 10 times the weight of water for the first time, extracting for 1.5 hours, adding 8 times the amount of water for the second time, extracting for 1 hour; adding 6 times the weight of water for the third time, extracting for 40 minutes, and combining Decoction, filter, add hydrochloric acid to the filtrate to adjust the pH value to 1-2, let it stand for 1 hour, take the precipitate, wash with water to make the pH value to 5-7, dry, pulverize, and sieve.

[0029] (2) Pulverize 1 / 2 of rhubarb and berberine hydrochloride respectively, sieve through a 100-mesh sieve, and set aside.

[0030] (3) 1 / 2 rhubarb is beaten into coarse powder, put into the extraction tank, add ethanol to reflux and extract twice, add 8 times the weight of 60% ethanol for the first time, ...

Embodiment 2

[0033] Rhubarb 300g Berberine hydrochloride 5g Scutellaria baicalensis 20g

[0034] Glucose 600g Microcrystalline Cellulose 200g Magnesium Stearate 1.5g

[0035] (1) Scutellaria baicalensis was extracted three times, adding 10 times the amount of water for the first time, extracting for 1.5 hours, adding 8 times the amount of water for the second time, extracting for 1 hour; adding 6 times the amount of water for the third time, extracting for 40 minutes, and combining Decoction, filter, add hydrochloric acid to the filtrate to adjust the pH value to 1-2, let it stand for 1 hour, take the precipitate, wash with water to make the pH value to 5-7, dry, pulverize, and sieve.

[0036] (2) Pulverize 1 / 2 of rhubarb and berberine hydrochloride respectively, sieve through a 100-mesh sieve, and set aside.

[0037] (3) 1 / 2 rhubarb is beaten into coarse powder, put into the extraction tank, add ethanol to reflux for extraction twice, add 8 times the amount of 60% ethanol for the first t...

Embodiment 3

[0040] Rhubarb 300g Berberine hydrochloride 5g Scutellaria baicalensis 20g

[0041] Glucose 500g Microcrystalline Cellulose 300g Magnesium Stearate 2g

[0042] (1) Scutellaria baicalensis was extracted three times, adding 10 times the amount of water for the first time, extracting for 1.5 hours, adding 8 times the amount of water for the second time, extracting for 1 hour; adding 6 times the amount of water for the third time, extracting for 40 minutes, and combining Decoction, filter, add hydrochloric acid to the filtrate to adjust the pH value to 1-2, let it stand for 1 hour, take the precipitate, wash with water to make the pH value to 5-7, dry, pulverize, and sieve.

[0043] (2) Pulverize 1 / 2 of rhubarb and berberine hydrochloride respectively, sieve through a 100-mesh sieve, and set aside.

[0044] (3) 1 / 2 rhubarb is beaten into coarse powder, put into the extraction tank, add ethanol to reflux for extraction twice, add 8 times the amount of 60% ethanol for the first tim...

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Abstract

The invention discloses rheum officinale, berberine hydrochloride and scutellaria baicalensis granules and a preparation method thereof. The rheum officinale, berberine hydrochloride and scutellaria baicalensis granules are prepared from the following raw materials and auxiliary materials in parts by weight: 250 to 350 parts of rheum officinale, 3 to 5 parts of berberine hydrochloride, 15 to 30 parts of scutellaria baicalensis, 400 to 600 parts of glucose, 200 to 300 parts of microcrystalline cellulose and 1 to 2 parts of magnesium stearate. The rheum officinale, berberine hydrochloride and scutellaria baicalensis granules have high content of frangula emodin and chrysophanol and rapid pharmacological function; furthermore, the granules can be quickly dissolved in water to prepare clarified and transparent liquid with good taste and are convenient to take; the biological utilization rate is high; furthermore, the preparation method is simple, and no special equipment is required; the rheum officinale, berberine hydrochloride and scutellaria baicalensis granules are suitable for industrial production.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine preparations, in particular to a Sanhuang granule and a preparation method thereof. Background technique [0002] Sanhuang Tablet is composed of rhubarb, berberine hydrochloride, and baicalin. It has the effects of clearing heat and detoxifying, purging fire and laxative. It is used for conjunctival congestion and swelling, mouth and nose sores, throat swelling and pain, gum swelling and pain, vexation and thirst, yellow urine and constipation caused by excessive heat of Sanjiao. [0003] The Chinese patent application whose publication number is CN1709352A discloses a Sanhuang dispersible tablet and a preparation method thereof. The preparation method is to obtain Huangling extract after decocting Huangling with water. Take 50% of the weight of rhubarb and grind it into fine powder; the remaining rhubarb is crushed into coarse powder, add 15-45% ethanol to extract, filter, recover the...

Claims

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Application Information

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IPC IPC(8): A61K36/708A61K9/16A61K47/26A61K47/38A61P1/10A61P11/04A61P1/02A61K31/4375
CPCA61K9/0095A61K9/1623A61K9/1652A61K31/4375A61K36/539A61K36/708A61K2236/331A61K2236/333A61K2236/39A61K2300/00
Inventor 刘景萍刘全国陈克领林文君
Owner HAINAN HULUWA PHARMA GRP CO LTD
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