Preparation method of L-p-chlorophenylalanine
A technology of p-chlorophenylalanine and hydrochloric acid, which is applied in the field of preparation of L-p-chlorophenylalanine, can solve the problems of large reaction volume, increased concentration cost, and low solubility, and achieves low cost, simple method, The effect of high yield
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[0013] A preparation method of L-p-chlorophenylalanine, said method comprising the steps of:
[0014] 1. Synthesis of acetylated D,L-p-chlorophenylalanine:
[0015] D, L-p-chlorophenylalanine, soluble in water, adjust the pH to 10 with alkali, control the temperature at 0-5°C, add acetic anhydride dropwise, use 5N sodium hydroxide to control the pH during the reaction, and use indene for the reaction solution Triketone develops color until the amino acid no longer develops color, indicating that all amino acids are acetylated. Add hydrochloric acid to adjust the pH to 1-2, and a large amount of precipitated products appear. The crystals are collected by filtration, washed with acid water, and dried. The yield is 90%.
[0016] 2. Dissolve acetylated D,L-p-chlorophenylalanine at 80°C, the concentration can reach 0.7M, add purified L-high temperature resistant acylase, react for 48 hours, and use liquid phase detection to resolve The degree of deacetylation of L-p-chlorophenyla...
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