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A kind of preparation method of Wuwei Huanglian medicinal composition

A composition, the technology of Coptis chinensis, applied in the field of medicine, can solve the problems of slow release of active ingredients, affecting the absorption and utilization of active ingredients, multiple precipitation and precipitation, etc.

Active Publication Date: 2019-07-26
SHANDONG JINHE DRUG RES DEV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The preparation method of Wuwei Huanglian Pills is that the crude drug is crushed and directly used as medicine, and its active ingredients are released slowly, which affects the absorption and utilization of the active ingredients in the medicine.
In the extraction test of Wuwei Huanglian Pills, it was found that when all the medicinal materials were combined and extracted, the extraction rate of the active ingredients berberine and hydroxysafflower yellow A was not high when extracted with water; when extracted with ethanol, there were more precipitation during the concentration of the extract Precipitation is not conducive to the subsequent process

Method used

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  • A kind of preparation method of Wuwei Huanglian medicinal composition
  • A kind of preparation method of Wuwei Huanglian medicinal composition
  • A kind of preparation method of Wuwei Huanglian medicinal composition

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0023] Experimental example 1 Extraction effect of different combinations of coptis, safflower and myrobalan

[0024] 1. Medicinal materials and reagents

[0025] Coptidis, safflower, and myrobalan were all provided by Jinhe Tibetan Medicine Co., Ltd., batch number: Coptis 20130805; safflower 20131001; myrobalan 20131102.

[0026] 2. Method

[0027] The composition of Wuwei Huanglian Pills is: 300g of Coptis chinensis, 160g of safflower, 200g of myrobalan, 80g of slag taming paste, and 1g of musk. Which only involves the extraction of coptis, safflower and myrobalan. To this end, the experimental investigation of the interaction of decoction in different combinations of three kinds of medicinal materials was carried out.

[0028] 1. Selection of extraction solvent

[0029] From Li Mingyue's "Research on the Extraction Process of Coptidis Rhizoma": use water and ethanol as solvents to extract berberine (i.e. berberine) in Coptis Rhizoma respectively, and adopt HPLC method t...

experiment example 2

[0063] Experimental example 2. The influence of different ratios of myrobalan on the extraction effect of safflower and coptis

[0064] 1. Medicinal materials

[0065] Coptidis, safflower, and myrobalan were all provided by Jinhe Tibetan Medicine Co., Ltd., batch number: Coptis 20130805; safflower 20131001; myrobalan 20131102.

[0066] 2. Method

[0067] Experimental example 1 shows that myrobalan can promote the extraction of safflower or coptis, and this experimental example continues to investigate the influence of different proportions of myrobalan on the extraction effect of safflower and coptis.

[0068] Parallel 7 groups of experiments: each group safflower 16g, coptis 30g, myrobalan 20g. According to Table 6, the proportioning of myrobalan, safflower and coptis. Add water to decoct each group of medicinal materials twice, first add water with a volume 10 times the weight of the medicinal materials, decoct for 2 hours, add water with a volume 8 times the weight of th...

Embodiment 1

[0080] A preparation method of Wuwei Huanglian medicinal composition, comprising the following steps:

[0081] (1) Take 300g of Coptis chinensis and 80g of myrobalan, add water to decoct twice, add 3800mL of water 10 times the volume of the medicinal materials for the first time, decoct for 2 hours, add water 8 times the weight and volume of the medicinal materials for the second time, decoct Boil for 1 hour, combine the extracts, filter, concentrate, and dry to obtain extract A;

[0082] (2) Get 160g of safflower and 120g of myrobalan, add water to decoct twice, add 2800mL of water of 10 times the volume of the medicinal material for the first time, decoct for 2 hours, add water of 8 times the weight of the medicinal material for the second time, Decoct for 1 hour, combine the extracts, filter, concentrate, and dry to obtain extract B;

[0083] (3) Take 80 g of the above-mentioned extract A, extract B and slag tame paste, pulverize to 200 mesh, then mix with 1 g of musk in e...

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Abstract

The invention discloses a preparation method of a five-flavor rhizome coptidis pharmaceutical composition.According to the method, rhizome coptidis and part of fructus chebulae are merged and extracted, flos carthami and part of fructus chebulae are merged and extracted, the extraction speed and extraction quantity of the effective ingredients berberine and tannin can be greatly increased, and the stability of hydroxysafflor yellow A is improved.When extraction is performed through the method, the transfer rate of berberine is 75.06%, the transfer rate of hydroxysafflor yellow A is 72.54%, and the transfer rate of tannin is 72.61%.

Description

technical field [0001] The invention relates to a preparation method of a Wuwei Coptidis Rhizoma medicinal composition, belonging to the technical field of medicine. Background technique [0002] Wuwei Huanglian Pills are recorded in "Drug Standards of the Ministry of Health of the People's Republic of China. Tibetan Medicine (Volume 1), Standard Number: WS 3 -BC-0273-95. It is composed of the following medicinal flavors: Coptidis 300g, safflower 160g, myrobalan 200g, slag taming cream 80g, musk 1g. The preparation method is as follows: the above five flavors, except musk and slag taming paste, are crushed into fine powder, blended with musk, sieved, mixed evenly, poured into pills with slag taming paste, added appropriate amount of water, and dried to obtain. [0003] The preparation method of Wuweihuanglian Pills is that the crude drug is crushed and directly used as medicine, and its active ingredients are released slowly, which affects the absorption and utilization o...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/718A61K35/55
Inventor 李怀平王海苹魏永义姬涛王朔
Owner SHANDONG JINHE DRUG RES DEV