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Full-automatic dissolvability testing device of flowing cell

A test device and flow cell technology, which is used in material inspection products, testing pharmaceutical preparations, etc.

Inactive Publication Date: 2016-07-20
YANBIAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The research on the flow cell method has just started in China, and the flow cell dissolution method has not been included in the Chinese Pharmacopoeia, and there has been no development and research on its device in China.

Method used

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  • Full-automatic dissolvability testing device of flowing cell
  • Full-automatic dissolvability testing device of flowing cell

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Effect test

specific Embodiment approach 2

[0014] Such as figure 2 As shown, the fully automatic flow cell dissolution test device provided by the present invention includes at least one set of flow cells and a controller, each flow cell is provided with a cylindrical glass bottle 5, and the periphery of the glass bottle 5 is provided with a sandwich type thermostatic water jacket 6. The upper port of the glass bottle 5 is provided with a cone-shaped filter 1, the inside of the glass bottle 5 is provided with a circular bayonet 4, and above the bayonet 4 is provided with a stainless steel mesh 24, on which a solid preparation 23 is placed, and the filter of each flow cell 1. A filter connecting hose 22 is commonly arranged on the outlet, and a three-way electromagnetic valve 26 is arranged on the other end of the filter connecting hose 22. The three-way electromagnetic valve 26 is provided with a solvent storage bottle connecting hose 21 and a sampling needle connecting flexible pipe. Pipe 27, the other end of solvent...

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Abstract

The invention discloses a full-automatic dissolvability testing device of a flowing cell. The full-automatic dissolvability testing device at least comprises one set of flowing cells and a controller, wherein each flowing cell is provided with a columnar glass bottle; a constant-temperature water jacket layer is arranged on each glass bottle; a filter is arranged at the upper end opening of each glass bottle; each glass bottle is internally provided with a round bayonet and a stainless steel net; a solid preparation is put on the net; filter outlets of each set of flowing cells are commonly provided with a filter connection hose; a three-way solenoid valve is arranged at the other end of the filter connection hose; the three-way solenoid valve is provided with a hose for connecting a solvent storage bottle or a waste liquid collection bottle and a sample collector; a lower end opening of each glass bottle is connected with a stainless steel pipe, a liquid outlet hose, a piston pump and a connection hose in sequence; the other end of each connection hose is arranged in the solvent bottle; and each stainless steel pipe is arranged in a heating water tank. The full-automatic dissolvability testing device of the flowing cell has the advantages of automatically controlling heating temperature and solvent flow speed, automatically selecting a solvent base, automatically sampling, and can doing open type work and can also do sealed type work.

Description

technical field [0001] The invention belongs to the technical field of drug dissolution test, in particular to a fully automatic flow cell dissolution test device. Background technique [0002] Dissolution test is a standard test item in the drug quality assurance system. Regardless of whether the dissolution results are related to the biological effects of the drug, the standard dissolution test is a simple and cheap method to investigate whether the physical properties of the drug are consistent. The flow cell method is a technology developed for the insurmountable difficulties in the current dissolution test methods. It is not only suitable for the dissolution test of oral solid long-release preparations such as tablets and capsules, but also suitable for drug release stents, implants, etc. Determination of the release rate of various drug sustained and controlled release preparations such as doses, microspheres, microtablets, liposomes, etc. The flow cell method has att...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/15
CPCG01N33/15
Inventor 朴相范方亮李东浩
Owner YANBIAN UNIV
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