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A special oral gel antidiarrheal agent for animals and preparation method thereof

A gel and antidiarrheal technology, applied in the fields of animal medicine and aquaculture, can solve the problems of easy to cause stress, time-consuming and labor-intensive injection and administration, difficult to grasp the dosage of medicine, etc., so as to avoid stress reaction and facilitate administration. precise effect

Active Publication Date: 2018-09-25
TIBET AGRI & ANIMAL HUSBANDRY COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the dosage forms of veterinary drugs currently on the market include liquid dosage forms, solid dosage forms, semi-solid dosage forms, gas dosage forms and special dosage forms, among which liquid dosage forms and solid dosage forms are the most common, and semi-solid dosage forms are relatively rare
Considering that there is currently no animal-specific oral gel antidiarrheal agent in China, the semi-solid dosage form of the oral gel overcomes the difficulty in controlling the dosage of the liquid dosage form and solid dosage form through mixing, drinking water or injection. Disadvantages of time-consuming and labor-intensive, easy to cause stress

Method used

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  • A special oral gel antidiarrheal agent for animals and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0110] A special oral gel antidiarrheal agent for calves, which is made of the following raw materials by weight:

[0111] Ingredients by weight

[0112] Sterile water 85

[0113] Glycerin 6

[0114] Tween-80 0.3

[0115] Agar 0.7

[0116] Milk flavor 0.2

[0117] Potassium Sorbate 0.3

[0118] Gelatin 0.6

[0119] Soluble starch 13

[0120] Methaquine 4.25

[0121] Gentamicin sulfate 2.6.

[0122] A preparation method of a special oral gel antidiarrheal agent for calves, the steps are:

[0123] a. Measure 40 parts by weight of sterile water in container A, put 13 parts by weight of soluble starch, 0.3 parts by weight of potassium sorbate, and 0.3 parts by weight of Tween-80 into the container, and stir well before use;

[0124] b. Weigh 6 parts by weight of glycerin, 0.7 parts by weight of agar, and 0.6 parts by weight of gelatin in container B, add 35 parts by weight of sterile water, and stir evenly;

[0125] c. Place container A in an electric furnace, stir and heat in a single direction at 1...

Embodiment 2

[0131] A special oral gel antidiarrheal agent for calves, which is made of the following raw materials by weight:

[0132] Ingredients by weight

[0133] Sterile water 80

[0134] Glycerin 7

[0135] Tween-80 0.3

[0136] Milk flavor 0.2

[0137] Potassium Sorbate 0.3

[0138] Sodium carboxymethyl cellulose 0.5

[0139] Soluble starch 12.5

[0140] Mequine 4

[0141] Gentamicin sulfate 2.5.

[0142] A preparation method of a special oral gel antidiarrheal agent for calves, the steps are:

[0143] a. Measure 40 parts by weight of sterile water into container A, put 13 parts by weight of soluble starch, 0.3 parts by weight of potassium sorbate, and 0.3 parts by weight of Tween-80 into it, and stir it for later use;

[0144] b. Weigh 7 parts by weight of glycerin and 0.5 parts by weight of sodium carboxymethyl cellulose, add 30 parts by weight of sterile water to container B, and let it stand for 8 hours and stir evenly;

[0145] c. Place container A in an electric furnace, stir and heat in a singl...

Embodiment 3-7

[0151] A special oral gel antidiarrheal agent for calves, which is made of the following raw materials by weight:

[0152]

3

4

5

6

7

Sterile water

60

70

85

105

105

glycerin

5.5

6

7

9

10

Tween-80

0.3

0.3

0.5

0.6

0.5

Agar

0.53

0

0.7

1.2

0

essence

0.15

0.15

0.2

0.3

0.4

Potassium sorbate

0.25

0.3

0.3

0.45

0.45

gelatin

0.38

0

0.5

0.9

0

Sodium carboxymethyl cellulose

0

0.35

0

0

0.7

Soluble starch

9.5

12

12.5

16.5

14

Gentamicin Sulfate

1.8

2.15

2.5

3.2

3.2

Methaquine

3

3.5

4

5.2

5.2

[0153] The preparation steps are the same as in Examples 1 and 2.

[0154] Evaluation: The matrix is ​​uniform and transparent, delicate, without granular agglomerates; after adding the drug, it appears light yellow, has a suitable viscosity, and its Ph value is about 6.5; take 10g of this product and centrifuge at 3000r / min for 30 minutes without stratification; at room temperature There is no obvious change in its properties (color, viscosity, ductility, etc.) after being placed at 20°C for 15 days, 30 days, 60 days, 120 days, and 180 days....

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Abstract

The invention discloses a special oral gel antidiarrheal agent for yak calf and a preparation method thereof. The agent comprises Mequindox, gentamicin sulfate, glycerin, a thickener, a creamy flavor, potassium sorbate, Tween-80, sterile water and soluble starch. The method comprises the steps of: 1, measuring sterile water, adding the sterile water in a container A, adding the weighed soluble starch, potassium sorbate and Tween-80 into the container, and stirring uniformly; 2, weighing and adding glycerin and thickener into a container B, adding sterile water, and stirring evenly; 3, placing the container A on an electric furnace, stirring and heating until starch gelatinization; 4, placing the container B in a water bath to completely dissolve the thickener to form a transparent homogeneous liquid; 5, slowly pouring the liquid B into A until the liquids A and B have similar temperature, and stir uniformly; and 6, weighing gentamicin sulfate, dissolving in sterile water, adding Mequindox and stirring uniformly; and 7, pouring the liquid into gel, and adding a creamy flavor to obtain a gel agent. The gel agent has the advantages of usage safety, reasonable formula, simple operation, and substantial curative effect.

Description

Technical field [0001] The invention relates to the field of animal medicine and breeding, and more specifically to an oral gel antidiarrheal agent for calves, and also relates to a formula and preparation method of an oral gel antidiarrheal agent for calves, which is suitable for treating calf yak bacteria Sexual diarrhea diseases, reduce the mortality of young cattle diarrhea, and effectively improve the production performance of yak. Background technique [0002] With the increasingly frequent exchanges between regions and the change of climate in different seasons, diarrhea diseases in calves caused by related bacteria have occurred more frequently, causing more and more damage to the yak, and seriously restricting the healthy development of production in pastoral areas. The use of oral gel antidiarrheal agents for the treatment of bacterial diarrhea in calves is an effective way to reduce the mortality of young cattle from diarrhea and improve the production performance of y...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/7036A61P1/12A61P31/04A61K31/498
Inventor 李家奎汪小强姜文腾韩照清
Owner TIBET AGRI & ANIMAL HUSBANDRY COLLEGE