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Special oral gel antidiarrheal agent for animal and preparation method thereof

A gel and antidiarrheal technology, which is applied in the field of breeding and animal medicine, can solve the problems of easy stress, time-consuming and labor-intensive injection administration, and rare semi-solid dosage forms, so as to ensure the protection from stress and the convenience of administration precise effect

Active Publication Date: 2016-08-17
TIBET AGRI & ANIMAL HUSBANDRY COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the dosage forms of veterinary drugs currently on the market include liquid dosage forms, solid dosage forms, semi-solid dosage forms, gas dosage forms and special dosage forms, among which liquid dosage forms and solid dosage forms are the most common, and semi-solid dosage forms are relatively rare
Considering that there is currently no animal-specific oral gel antidiarrheal agent in China, the semi-solid dosage form of the oral gel overcomes the difficulty in controlling the dosage of the liquid dosage form and solid dosage form through mixing, drinking water or injection. Disadvantages of time-consuming and labor-intensive, easy to cause stress

Method used

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  • Special oral gel antidiarrheal agent for animal and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0110] A special oral gel antidiarrheal agent for calves, which is made of the following raw materials in parts by weight:

[0111] Raw material parts by weight

[0112] Sterile water 85

[0113] Glycerin 6

[0114] Tween-80 0.3

[0115] Agar 0.7

[0116] Milk flavor 0.2

[0117] Potassium sorbate 0.3

[0118] Gelatin 0.6

[0119] Soluble starch 13

[0120] Methaquine 4.25

[0121] Gentamicin Sulfate 2.6.

[0122] A kind of preparation method of special oral gel antidiarrheal agent for calving yak, its steps are:

[0123] a. Measure 40 parts by weight of sterile water in container A, place 13 parts by weight of soluble starch, 0.3 parts by weight of potassium sorbate, and 0.3 parts by weight of Tween-80 in the container A, and stir them evenly for later use;

[0124] b. Weigh 6 parts by weight of glycerin, 0.7 parts by weight of agar, and 0.6 parts by weight of gelatin in container B, add 35 parts by weight of sterile water, and stir evenly;

[0125] c. Place contai...

Embodiment 2

[0131] A special oral gel antidiarrheal agent for calves, which is made of the following raw materials in parts by weight:

[0132] Raw material parts by weight

[0133] Sterile water 80

[0134] Glycerin 7

[0135] Tween-80 0.3

[0136] Milk flavor 0.2

[0137] Potassium sorbate 0.3

[0138] Sodium carboxymethyl cellulose 0.5

[0139] Soluble starch 12.5

[0140] Methaquine 4

[0141] Gentamicin Sulfate 2.5.

[0142] A kind of preparation method of special oral gel antidiarrheal agent for calving yak, its steps are:

[0143] a. Measure 40 parts by weight of sterile water in container A, place 13 parts by weight of soluble starch, 0.3 parts by weight of potassium sorbate, and 0.3 parts by weight of Tween-80 in the container A, and stir them evenly for later use;

[0144] b. Weigh 7 parts by weight of glycerin and 0.5 parts by weight of sodium carboxymethyl cellulose, add 30 parts by weight of sterile water to container B, and let stand for 8 hours, stirring evenly;

...

Embodiment 3-7

[0151] A special oral gel antidiarrheal agent for calves, which is made of the following raw materials in parts by weight:

[0152] 3 4 5 6 7 sterile water 60 70 85 105 105 glycerin 5.5 6 7 9 10 Tween-80 0.3 0.3 0.5 0.6 0.5 agar 0.53 0 0.7 1.2 0 essence 0.15 0.15 0.2 0.3 0.4 Potassium sorbate 0.25 0.3 0.3 0.45 0.45 gelatin 0.38 0 0.5 0.9 0 Sodium carboxymethyl cellulose 0 0.35 0 0 0.7 soluble starch 9.5 12 12.5 16.5 14 Gentamicin Sulfate 1.8 2.15 2.5 3.2 3.2 Acetyl Mequin 3 3.5 4 5.2 5.2

[0153] Its preparation steps are identical with embodiment 1,2.

[0154] Evaluation: The matrix is ​​uniform and transparent, fine and fine, without granular aggregates; after adding the drug, it appears light yellow, with a suitable viscosity, and its Ph value is around 6.5; take 10g of this product and centrifuge at 3000r / min for 30 minutes without delamination...

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Abstract

The invention discloses a special oral gel antidiarrheal agent for yak calf and a preparation method thereof. The agent comprises Mequindox, gentamicin sulfate, glycerin, a thickener, a creamy flavor, potassium sorbate, Tween-80, sterile water and soluble starch. The method comprises the steps of: 1, measuring sterile water, adding the sterile water in a container A, adding the weighed soluble starch, potassium sorbate and Tween-80 into the container, and stirring uniformly; 2, weighing and adding glycerin and thickener into a container B, adding sterile water, and stirring evenly; 3, placing the container A on an electric furnace, stirring and heating until starch gelatinization; 4, placing the container B in a water bath to completely dissolve the thickener to form a transparent homogeneous liquid; 5, slowly pouring the liquid B into A until the liquids A and B have similar temperature, and stir uniformly; and 6, weighing gentamicin sulfate, dissolving in sterile water, adding Mequindox and stirring uniformly; and 7, pouring the liquid into gel, and adding a creamy flavor to obtain a gel agent. The gel agent has the advantages of usage safety, reasonable formula, simple operation, and substantial curative effect.

Description

technical field [0001] The present invention relates to the fields of animal medicine and breeding, more specifically to a special oral gel antidiarrheal agent for calf yak, and also relates to a formula and preparation method of an oral gel antidiarrheal agent special for calf yak, which is suitable for treating calf yak bacteria diarrheal diseases, reduce the mortality rate of juvenile cattle diarrhea, and effectively improve the production performance of yaks. Background technique [0002] With the increasing frequency of exchanges between regions and the change of climate in different seasons, calf diarrhea caused by related bacteria occurs more frequently, causing more and more harm to yaks, which seriously restricts the healthy development of production in pastoral areas. Using oral gel antidiarrheal agent to treat calf yak bacterial diarrhea is an effective way to reduce the mortality rate of young cattle from diarrhea and improve the production performance of yaks. ...

Claims

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Application Information

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IPC IPC(8): A61K31/7036A61P1/12A61P31/04A61K31/498
Inventor 李家奎汪小强姜文腾韩照清
Owner TIBET AGRI & ANIMAL HUSBANDRY COLLEGE