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Sodium aescinate liniment

A escin sodium and solvent technology, which is applied in the direction of anti-inflammatory agents, non-central analgesics, medical preparations of non-active ingredients, etc., can solve the problem of poor transdermal absorption, large skin irritation, poor stability, etc. problem, to achieve good transdermal absorption effect, less skin irritation and good stability

Active Publication Date: 2016-08-24
WUHAN AIMIN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] But existing aescin sodium liniment has following shortcoming: 1. transdermal absorption effect is not good; 2. stability is relatively poor, and aescin A, B, C, D content change greatly; larger

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A escin sodium liniment consists of the following ingredients in proportion by weight:

[0028]

[0029] Described thickener is polyvinylpyrrolidone;

[0030] The penetration enhancer is laurocapram;

[0031] The solvent is ethanol aqueous solution with a mass ratio of 30%.

[0032] The preparation method is as follows:

[0033] Take 30% ethanol aqueous solution, use tartaric acid to adjust the pH to 5, then add sodium aescinate, polyvinylpyrrolidone and laurocapram, stir to dissolve, and obtain the product.

Embodiment 2

[0035] A escin sodium liniment consists of the following ingredients in proportion by weight:

[0036]

[0037] The thickener is selected from gelatin and carbomer, and the mass ratio of the gelatin and carbomer is 1:1;

[0038] The penetration enhancer is selected from borneol and limonene, and the mass ratio of borneol to limonene is 2:1;

[0039] The solvent is ethanol aqueous solution with a mass ratio of 60%.

[0040] The preparation method is as follows:

[0041] Take 60% ethanol aqueous solution, adjust pH to 6 with hydrochloric acid, then add sodium aescinate, gelatin, carbomer, borneol, limonene, stir to dissolve, and obtain the product.

Embodiment 3

[0043] A escin sodium liniment consists of the following ingredients in proportion by weight:

[0044]

[0045] Described thickener is hydroxypropyl methylcellulose and polyvinyl alcohol, and the mass ratio of described hydroxypropyl methylcellulose and polyvinyl alcohol is 2: 1;

[0046] The penetration enhancer is propylene glycol and eucalyptus oil, and the mass ratio of the propylene glycol to eucalyptus oil is 6:1.

[0047] The solvent is ethanol aqueous solution with a mass ratio of 40%.

[0048] The preparation method is as follows:

[0049] Take 40% ethanol aqueous solution, adjust the pH to 5.5, then add sodium aescinate, hydroxypropyl methylcellulose, polyvinyl alcohol, propylene glycol, and eucalyptus oil, stir and dissolve, and obtain the product.

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PUM

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Abstract

The invention discloses sodium aescinate liniment. The sodium aescinate liniment is prepared from components as follows: 0.1%-2% of sodium aescinate, 0.1%-5% of a thickening agent, 1%-5% of a penetration enhancer and the balance of a solvent with the pH being 5-6. The sodium aescinate liniment has the advantages of good transdermal absorption effect, good stability, low irritation to skin and the like.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a escin sodium liniment. Background technique [0002] Aescin sodium is a saponin sodium salt extracted from the dried mature seeds of Aesculus Wilsonii Rehd. Salazi is a commonly used traditional Chinese medicine recorded in the 2015 edition of the Chinese Pharmacopoeia. It has the functions of soothing the liver, regulating qi, harmonizing the stomach, relieving pain, and killing insects. Modern pharmacological studies have proved that it also has anti-inflammatory, detumescent, anti-osmotic, and anti-cancer effects. Studies have shown that sodium aescinate mainly contains two aglycones, protoaescin and jasmine alcohol C saponin, and the components with higher content are aescin A, B, C, and D. Sodium aescinate can reduce the increase of pathological capillary permeability, increase venous tension, reduce the exudation of inflammatory substances, have an...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/00A61K31/704A61K47/32A61K47/42A61K47/44A61P19/04A61P29/00A61P35/00A61P9/14A61P7/00
CPCA61K9/0014A61K31/704A61K47/32A61K47/42A61K47/44
Inventor 石召华刘享平叶丽春关小羽赵小静李信炯
Owner WUHAN AIMIN PHARMA
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