Application of Danhong injection as terfenadine heart adverse effect antagonist

A technology of Danhong injection and terfenadine, applied in the application of Danhong injection, Danhong injection as the application field of terfenadine cardiac adverse reaction antagonist, to improve cardiac rhythm changes and enhance safety Effect

Inactive Publication Date: 2016-09-21
BIOLOGY INST OF SHANDONG ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Aiming at the present situation of existing terfenadine clinical adverse reactions, the technical problem to be solved by the present invention is to provide a kind of application of Danhong injection as terfenadine cardiac adverse reaction antagonist

Method used

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  • Application of Danhong injection as terfenadine heart adverse effect antagonist
  • Application of Danhong injection as terfenadine heart adverse effect antagonist
  • Application of Danhong injection as terfenadine heart adverse effect antagonist

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Embodiment 1, the application of Danhong injection as terfenadine cardiac adverse reaction antagonist

[0043] The clinical usage and dosage of Danhong injection as an antagonist of terfenadine torsades de pointes adverse reaction: intramuscular injection of 1-2ml once, 1-2 times a day.

Embodiment 2

[0044] Embodiment 2, the application of Danhong injection as terfenadine cardiac adverse reaction antagonist

[0045] Clinical usage and dosage of Danhong injection as an antagonist of terfenadine paroxysmal ventricular tachycardia adverse reactions: intravenous injection, 4ml once, add 20ml of glucose injection with a mass concentration of 50% and dilute and inject slowly, 1-1 day 2 times.

Embodiment 3

[0046] Embodiment 3, the application of Danhong injection as terfenadine cardiac adverse reaction antagonist

[0047] Clinical usage and dosage of Danhong injection as an antagonist of terfenadine sinus bradycardia with arrhythmia adverse reaction: intramuscular injection of 1-2ml once, 1-2 times a day.

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PUM

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Abstract

The invention discloses an application of a Danhong injection as a terfenadine heart adverse effect antagonist. The application overcomes the technology bias of the prior art on the aspect of application, and experiments show that the Danhong injection has a remarkable effect of improving the heart rhythm change, caused by terfenadine, of a zebra fish. In addition, when the concentration of the Danhong injection is less than or equal to 30muL/mL, the normal zebra fish does not show an obvious teratogenic effect after 6 days of continuous injection. On the basis of the extensive clinical application of the Danhong injection, a theoretical foundation is provided for the drug combination of the terfenadine and the enhancement of the safety of the terfenadine.

Description

technical field [0001] The invention relates to the application of Danhong injection, in particular to the application of Danhong injection as an antagonist of adverse cardiac reactions of terfenadine, and belongs to the technical field of drug development. Background technique [0002] With the development of society and economy, especially the aging of the population and the acceleration of urbanization, the prevalence of cardiovascular disease risk factors in China is on the rise, leading to a continuous increase in the number of cardiovascular diseases. According to the "China Cardiovascular Disease Report 2014", there are 290 million patients with cardiovascular disease nationwide, and 1 in every 5 adults suffers from cardiovascular disease. The death rate of cardiovascular disease ranks first among all kinds of diseases, and there are 2 cases of cardiovascular diseases in every 5 deaths. According to the "China Cardiovascular Disease Report 2014", a retrospective surv...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/537A61K9/08A61P9/06
CPCA61K36/537A61K9/0019A61K9/08A61K36/286A61K2300/00
Inventor 何秋霞韩利文刘可春彭维兵楚杰韩建张云王希敏侯海荣王雪孙晨王荣春张姗姗
Owner BIOLOGY INST OF SHANDONG ACAD OF SCI
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