Method for determining formaldehyde in electronic cigarette liquid

A technology of e-cigarette liquid and determination method, which is applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of e-cigarette liquid matrix complexity, large difference in matrix, and large difference in additives, and achieve good solubility , prevent aggregation, simple pre-treatment process

Inactive Publication Date: 2016-09-21
ZHENGZHOU TOBACCO RES INST OF CNTC
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AI Technical Summary

Problems solved by technology

Moreover, due to the wide variety of e-liquid brand specifications and the large differences in the additives of different f

Method used

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  • Method for determining formaldehyde in electronic cigarette liquid
  • Method for determining formaldehyde in electronic cigarette liquid
  • Method for determining formaldehyde in electronic cigarette liquid

Examples

Experimental program
Comparison scheme
Effect test

Example Embodiment

[0030] Example 1

[0031] The standard solution of formaldehyde-2,4-dinitrophenylhydrazone was analyzed by LC-MS / MS. Regression analysis was performed on the peak area ratio of the target and internal standard quantitative ion to the concentration of formaldehyde, and the formaldehyde standard working curve and regression equation were obtained. The detection limit (LOD) was calculated with 3 times the signal-to-noise ratio (S / N = 3), and the specific detection The results are shown in Table 2:

[0032] Table 2 Test results of formaldehyde standard working solution

[0033] Compound

Example Embodiment

[0034] Example 2

[0035] The spike recovery experiment was carried out at three concentration levels of low, medium and high. Each spiked level was repeated 6 times. The recovery and precision of each spiked level were calculated based on the measured amount and spiked amount. The specific results are shown in the following table:

[0036] Table 3 Method recovery rate and repeatability

[0037]

Example Embodiment

[0038] Example 3

[0039] Weigh 0.2 g of an e-cigarette liquid sample, add 0.6~3.0 mL deionized water, 0.4~3.0 mL DNPH derivatization reagent and 50~500 µL HClO respectively 4 Aqueous solution, shake well, and place at room temperature for 30-150 min for derivatization. After the reaction, add 50-500 µL of pyridine, add 100 µL of internal standard working solution, and dilute to 10 mL with acetonitrile, shake well, and pass 0.22 µm organic phase Filter membrane, enter LC-MS / MS analysis.

[0040] Substituting the target and internal standard quantitative ion to peak area ratio into the regression equation, the formaldehyde content in the sample was calculated to be 0.47 µg / g.

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Abstract

The invention relates to a rapid analysis method for determining formaldehyde in electronic cigarette liquid. The method comprises the following steps that firstly, a dispersant is added to an electronic cigarette liquid sample, then a DNPH derivatization reagent and an acid solution are added to perform derivatization reaction, an alkaline reagent and an internal standard substance are added, and finally the formaldehyde content in the electronic cigarette liquid is determined through LC-MS/MS analysis. The method is high in sensitivity, strong in anti-interference performance and good in repeatability, the pretreatment process is simple and rapid, and the method is suitable for detection of electronic cigarette liquid samples on a large scale.

Description

technical field [0001] The invention relates to a rapid analysis and determination method for formaldehyde in electronic cigarette liquid, belonging to the technical field of trace analysis. Background technique [0002] Formaldehyde, also known as formaldehyde, is a colorless, highly irritating gas at room temperature. Formaldehyde is a moderately toxic substance, LD 50 800 mg / kg (rat oral); 60~120 mg / m 3 Severe damage to the bronchi and lungs occurs 5 to 10 minutes after inhalation. The oral lethal dose is about 10-20 mL. Acute formaldehyde poisoning is a systemic disease mainly based on eye, respiratory system and central nervous system damage. Long-term exposure to low-concentration formaldehyde vapor may cause headaches, weakness and other symptoms. A large number of studies have shown that formaldehyde is mutagenic and carcinogenic, and the International Agency for Research on Cancer (IARC) has listed it as a Class 1 human carcinogen. [0003] In recent years, w...

Claims

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Application Information

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IPC IPC(8): G01N30/06G01N30/88
CPCG01N30/06G01N30/88G01N2030/027G01N2030/067
Inventor 潘立宁赵乐余晶晶刘克建陈黎樊美娟刘绍锋吕芳贾云祯刘惠民孟庆华
Owner ZHENGZHOU TOBACCO RES INST OF CNTC
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