A kind of preparation method of methylene blue-containing silica/tannic acid-iron particles that promotes methylene blue monomer release
A technology of methylene blue and silicon dioxide, which is applied to medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc., which can solve the problems of weakened release speed, unreported research, and limited control methods , to achieve faster release speed, good biocompatibility, and improve the effect of use
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Embodiment 1
[0027] (1) In a solution containing 92 milliliters of absolute ethanol and 17.2 milliliters of water, add 2.48 milliliters of ammonia water and stir evenly before adding methylene blue. After stirring for 10 minutes, add 3.44 milliliters of ethyl orthosilicate to make the concentration of methylene blue 2.32 Millimoles per liter, centrifuged after stirring for 4 hours and the sediment was washed twice with 92 milliliters of deionized water, then washed twice with 92 milliliters of absolute ethanol, and finally prepared into 20 milliliters of methylene blue-containing methylene blue with deionized water Silica colloidal solution;
[0028] (2) First prepare a tannic acid solution with a concentration of 40 mg / ml, then prepare a ferric chloride solution with a concentration of 10 mg / ml and adjust its pH value to 2.8 with ammonia water, then take 5 ml and prepare through step (1) and add 0.9 milliliters of ferric chloride solution therein, add 0.9 milliliters of tannic acid soluti...
Embodiment 2
[0035] (1) In a solution containing 92 milliliters of absolute ethanol and 17.2 milliliters of water, add 2.48 milliliters of ammonia water and stir evenly before adding methylene blue. After stirring for 10 minutes, add 3.44 milliliters of ethyl orthosilicate to make the concentration of methylene blue 2.32 Millimoles per liter, centrifuged after stirring for 4 hours and the sediment was washed twice with 92 milliliters of deionized water, then washed twice with 92 milliliters of absolute ethanol, and finally prepared into 20 milliliters of methylene blue with deionized water Silica colloidal solution;
[0036] (2) First prepare a tannic acid solution with a concentration of 40 mg / ml, then prepare a ferric chloride solution with a concentration of 10 mg / ml and adjust its pH value to 2.8 with ammonia water, then take 5 ml and prepare through step (1) colloidal solution and add 0.3 milliliters of ferric chloride solution therein, add 0.3 milliliters of tannic acid solutions aft...
Embodiment 3
[0040] (1) In a solution containing 92 milliliters of absolute ethanol and 17.2 milliliters of water, add 2.48 milliliters of ammonia water and stir evenly before adding methylene blue. After stirring for 10 minutes, add 3.44 milliliters of ethyl orthosilicate to make the concentration of methylene blue 2.32 Millimoles per liter, centrifuged after stirring for 4 hours and the sediment was washed twice with 92 milliliters of deionized water, then washed twice with 92 milliliters of absolute ethanol, and finally prepared into 20 milliliters of methylene blue-containing methylene blue with deionized water Silica colloidal solution;
[0041] (2) First prepare a tannic acid solution with a concentration of 40 mg / ml, then prepare a ferric chloride solution with a concentration of 10 mg / ml and adjust its pH value to 2.8 with ammonia water, then take 5 ml and prepare through step (1) and add 1.8 milliliters of ferric chloride solution therein, add 1.8 milliliters of tannic acid soluti...
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