SOD containing liposome sun-blocking and moisturizing spray and preparation method thereof
A moisturizing spray and liposome technology, which is applied to medical preparations containing active ingredients, skin care preparations, pharmaceutical formulas, etc., can solve the problems of skin feeling heavy, irritating, easy to whiten, etc., to achieve the goal of spraying The method is simple, easy to use and carry, and the effect of water resistance is good
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Embodiment 1
[0032] The liposome sunscreen moisturizing spray containing SOD is composed of the following components by mass:
[0033] 0.3 parts of SOD, 0.6 parts of β-glucan, 0.8 parts of fucoidan, 0.2 parts of γ-aminobutyric acid, 3 parts of lecithin, 0.5 parts of cholesterol, 0.2 parts of VC, 5 parts of lyophilized excipients, and 0.03 parts of preservatives Parts, 80 parts of PBS buffer solution, C0 2 5 copies, N 2 5 servings.
[0034] The preparation method of the described liposome sunscreen moisturizing spray containing SOD, comprises the following steps:
[0035] (1) Add lecithin, cholesterol, fucoidan, VC, and γ-aminobutyric acid into absolute ethanol, dissolve at 48-58°C, and spin the dissolved solution at a rotation speed of 40r / min, vacuum Degree of 0.02MPa, water bath temperature of 30 ℃ under the condition of rotary evaporation for 18min to form a uniform film, wherein the amount of absolute ethanol is the total mass of lecithin, cholesterol, fucoidan, VC and γ-aminobuty...
Embodiment 2
[0041] The liposome sunscreen moisturizing spray containing SOD is composed of the following components by mass:
[0042] 0.6 parts of SOD, 1 part of β-glucan, 1.2 parts of fucoidan, 0.5 parts of γ-aminobutyric acid, 6 parts of lecithin, 1 part of cholesterol, 0.5 parts of VC, 10 parts of lyophilized excipients, 0.05 parts of preservatives Parts, 95 parts of PBS buffer, C0 2 10 copies, N 2 10 servings.
[0043] The preparation method of the described liposome sunscreen moisturizing spray containing SOD, comprises the following steps:
[0044] (1) Add lecithin, cholesterol, fucoidan, VC, and γ-aminobutyric acid into absolute ethanol, dissolve at 58°C, and rotate the dissolved solution at a rotation speed of 45r / min and a vacuum degree of Rotary evaporation at 0.05MPa and water bath temperature of 48°C for 25 minutes to form a uniform film, in which the amount of absolute ethanol is 6 times the total mass of lecithin, cholesterol, fucoidan, VC and γ-aminobutyric acid ;
...
Embodiment 3
[0050] The liposome sunscreen moisturizing spray containing SOD is composed of the following components by mass:
[0051] 0.02 part of SOD, 0.08 part of β-glucan, 0.08 part of fucoidan, 0.01 part of γ-aminobutyric acid, 1 part of lecithin, 0.05 part of cholesterol, 0.05 part of VC, 1.5 part of lyophilized excipient, 0.01 part of preservative Parts, 70 parts of PBS buffer solution, C0 2 1 part, N 2 1 serving.
[0052] The preparation method of the described liposome sunscreen moisturizing spray containing SOD, comprises the following steps:
[0053] (1) Add lecithin, cholesterol, fucoidan, VC, and γ-aminobutyric acid into absolute ethanol, dissolve at 48°C, and rotate the dissolved solution at a rotation speed of 35r / min and a vacuum degree of Rotary evaporation at 0.008MPa and water bath temperature of 18°C for 10 minutes to form a uniform film, in which the amount of absolute ethanol is 4 times the total mass of lecithin, cholesterol, fucoidan, VC and γ-aminobutyric ac...
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