SOD containing liposome sun-blocking and moisturizing spray and preparation method thereof

A moisturizing spray and liposome technology, which is applied to medical preparations containing active ingredients, skin care preparations, pharmaceutical formulas, etc., can solve the problems of skin feeling heavy, irritating, easy to whiten, etc., to achieve the goal of spraying The method is simple, easy to use and carry, and the effect of water resistance is good

Inactive Publication Date: 2016-10-12
LIANYUNGANG LIFENG MEDICAL OXYGEN PROD CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Both sunscreen and sunscreen lotion are emulsion bases that are prone to deterioration and corruption, and it is difficult to achieve waterproof and water-resistant effects; sprays refer to preparations that do not contain propellants and are sprayed into mist by means of the pressure of a manual pump. In terms of dosage form, the sunscreen spray is easy to carry and use. It is sprayed directly on the skin in mist form. It does not need to be applied by hand, does not stick to hands, and can reduce losses at the same time. However, there are many problems in the existing sunscreen spray. The sunscreen agent is directly dispersed in the spray. , when in direct contact with the skin, there will be an irritating reaction. At the same time, because the general sunscreen is an emulsion matrix, which is suitable for microbial growth, it is easy to deteriorate and corrupt, and it is difficult to achieve waterproof and water resistance.
Moreover, cream sunscreens are prone to whitening after application; the texture is generally thicker, and the skin will feel heavy after application

Method used

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  • SOD containing liposome sun-blocking and moisturizing spray and preparation method thereof
  • SOD containing liposome sun-blocking and moisturizing spray and preparation method thereof
  • SOD containing liposome sun-blocking and moisturizing spray and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The liposome sunscreen moisturizing spray containing SOD is composed of the following components by mass:

[0033] 0.3 parts of SOD, 0.6 parts of β-glucan, 0.8 parts of fucoidan, 0.2 parts of γ-aminobutyric acid, 3 parts of lecithin, 0.5 parts of cholesterol, 0.2 parts of VC, 5 parts of lyophilized excipients, and 0.03 parts of preservatives Parts, 80 parts of PBS buffer solution, C0 2 5 copies, N 2 5 servings.

[0034] The preparation method of the described liposome sunscreen moisturizing spray containing SOD, comprises the following steps:

[0035] (1) Add lecithin, cholesterol, fucoidan, VC, and γ-aminobutyric acid into absolute ethanol, dissolve at 48-58°C, and spin the dissolved solution at a rotation speed of 40r / min, vacuum Degree of 0.02MPa, water bath temperature of 30 ℃ under the condition of rotary evaporation for 18min to form a uniform film, wherein the amount of absolute ethanol is the total mass of lecithin, cholesterol, fucoidan, VC and γ-aminobuty...

Embodiment 2

[0041] The liposome sunscreen moisturizing spray containing SOD is composed of the following components by mass:

[0042] 0.6 parts of SOD, 1 part of β-glucan, 1.2 parts of fucoidan, 0.5 parts of γ-aminobutyric acid, 6 parts of lecithin, 1 part of cholesterol, 0.5 parts of VC, 10 parts of lyophilized excipients, 0.05 parts of preservatives Parts, 95 parts of PBS buffer, C0 2 10 copies, N 2 10 servings.

[0043] The preparation method of the described liposome sunscreen moisturizing spray containing SOD, comprises the following steps:

[0044] (1) Add lecithin, cholesterol, fucoidan, VC, and γ-aminobutyric acid into absolute ethanol, dissolve at 58°C, and rotate the dissolved solution at a rotation speed of 45r / min and a vacuum degree of Rotary evaporation at 0.05MPa and water bath temperature of 48°C for 25 minutes to form a uniform film, in which the amount of absolute ethanol is 6 times the total mass of lecithin, cholesterol, fucoidan, VC and γ-aminobutyric acid ;

...

Embodiment 3

[0050] The liposome sunscreen moisturizing spray containing SOD is composed of the following components by mass:

[0051] 0.02 part of SOD, 0.08 part of β-glucan, 0.08 part of fucoidan, 0.01 part of γ-aminobutyric acid, 1 part of lecithin, 0.05 part of cholesterol, 0.05 part of VC, 1.5 part of lyophilized excipient, 0.01 part of preservative Parts, 70 parts of PBS buffer solution, C0 2 1 part, N 2 1 serving.

[0052] The preparation method of the described liposome sunscreen moisturizing spray containing SOD, comprises the following steps:

[0053] (1) Add lecithin, cholesterol, fucoidan, VC, and γ-aminobutyric acid into absolute ethanol, dissolve at 48°C, and rotate the dissolved solution at a rotation speed of 35r / min and a vacuum degree of Rotary evaporation at 0.008MPa and water bath temperature of 18°C ​​for 10 minutes to form a uniform film, in which the amount of absolute ethanol is 4 times the total mass of lecithin, cholesterol, fucoidan, VC and γ-aminobutyric ac...

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Abstract

The invention discloses a SOD containing liposome sun-blocking and moisturizing spray and a preparation method thereof and belongs to the technical field of cosmetic production. The problem that a sun-blocking and moisturizing agent is directly dispersed in the spray in an existing product, skin irritation reaction is caused, the sun-blocking and moisturizing emulsion easily deteriorates and decays and the sun-blocking and moisturizing spray is poor in waterproof and water-resistant effect is solved. The preparation method includes the following steps that lecithin, cholesterol and the like are added to an anhydrous ethanol to be dissolved, and then rotary evaporation is performed to obtain a film; a freeze-drying excipient and a preservative are dissolved in a PBS buffer, then beta-dextran is added to prepare a water mixture; the water mixture is added to the film, stirring is performed, water bath stirring is performed after the film is completely dissolved, and then ultrasonic treatment is performed to obtain a crude liposome; the crude liposome is subjected to freezing and thawing treatment, SOD is added, ultrasonic treatment is performed to obtain refined SOD liposome suspension liquid; filling is performed to obtain the product. The preparation method can be used for preparation of the SOD containing liposome sun-blocking and moisturizing spray.

Description

technical field [0001] The invention relates to a liposome sunscreen and moisturizing spray containing SOD and a preparation method thereof, belonging to the technical field of cosmetic production. Background technique [0002] SOD is the abbreviation of superoxide dismutase (Superoxide Dismutase). It is a specific scavenger for oxygen free radicals. It has strong anti-inflammation, anti-radiation, anti-aging and cosmetic effects. Diseases, can effectively eliminate or reduce wrinkles, acne and pigmentation (including freckles, chloasma, butterfly spots, pregnancy spots, age spots, sun spots). [0003] Common sunscreen and moisturizing skin care products currently on the market include dosage forms such as moisturizing spray, sunscreen, sunscreen lotion and sunscreen spray. Both sunscreen and sunscreen lotion are emulsion bases that are prone to deterioration and corruption, and it is difficult to achieve waterproof and water-resistant effects; sprays refer to preparations ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K8/66A61K8/14A61K8/04A61K8/44A61K8/55A61K8/63A61K8/67A61K8/73A61Q17/04A61Q19/00
CPCA61K8/14A61K8/046A61K8/44A61K8/553A61K8/63A61K8/66A61K8/676A61K8/73A61K2800/84A61Q17/04A61Q19/00
Inventor 李金明丁峰李珣丁剑秋
Owner LIANYUNGANG LIFENG MEDICAL OXYGEN PROD CO LTD
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