Influenza vaccine needle-free injection system and application

A technology of needle-free injection and flu vaccine, which is applied in the field of medicine and infectious diseases, and can solve problems such as needle-stick injuries and dangers

Inactive Publication Date: 2016-10-12
CHANGCHUN HAIJIYA BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, the injection method commonly used at home and abroad is to use an injection needle made of stainless st

Method used

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  • Influenza vaccine needle-free injection system and application
  • Influenza vaccine needle-free injection system and application
  • Influenza vaccine needle-free injection system and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0072] Embodiment 1, the preparation of needle-free injection ampoule

[0073] The present invention will be described in detail below in conjunction with the accompanying drawings and embodiments.

[0074] Such as figure 1 A. figure 1 As shown in B, the needle-free injection ampoule of prepacked vaccine or medicine provided by the present invention includes a tube body 1, a needle-free syringe joint 2, a power push rod 3, a jetting port 4, a stop rod 5, A sealing cap 6 and a sealing lock block 7; wherein, the tube body 1 is used for pre-filling a fixed and precise dose of vaccine or medicine, the needle-free syringe connector 2 is integrally arranged at one end of the tube body 1, and the power push rod 3 is controlled by the tube body The other end of 1 is slidingly arranged in the tube body 1, and closes the tube body 1; the injection port 4 is set in the needleless syringe joint 2, which has a stop groove 8, and the injection port 4 passes through the stop slot 8 and the...

Embodiment 2

[0086] Embodiment 2, preparation and application of needle-free influenza vaccine system

[0087] The needle-free influenza vaccine system of this embodiment includes a needle-free injection ampoule filled with a standard dose of influenza vaccine of not more than 15 μg (in terms of HA content) and a matching needle-free injector.

[0088] 1. Exploration of the injection depth of the needle-free influenza vaccine system

[0089] Fill the ink aqueous solution instead of the vaccine into the needle-free injection ampoule prepared in Example 1 to obtain the needle-free injection ampoule filled with the ink aqueous solution.

[0090] The aqueous ink solution is to filter the common blue-black ink with a filter membrane with a pore size of 0.22um, collect the filtrate and dilute it with water for injection to obtain an aqueous ink solution with a concentration of 1%.

[0091] Connect the needle-free injection ampoule filled with 0.1ml ink aqueous solution to the MIT needle-free sy...

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PUM

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Abstract

The invention discloses an influenza vaccine needle-free injection system and application. The influenza vaccine needle-free injection system comprises a needle-free injection ampoule filled with a vaccine which is monovalent or multivalent, and the HA content of each vaccine in monovalent or multivalent vaccines is 3-15 microgramme. Experiments prove that when the influenza vaccine needle-free injection system is used for immunization, the antigen dosage only accounts for part of a traditional intramuscular injection antigen dosage, and the same or higher HI titer can be generated. It is further indicated that a needle-free immune means is an ideal means capable of being selected by the influenza immunization vaccine.

Description

technical field [0001] The invention relates to the field of medicine, especially the field of infectious diseases. More specifically, it relates to a needle-free influenza vaccine system and application. It is suitable for various types of influenza vaccine immunization and vaccination. Background technique [0002] The ideal vaccination system should be safe, effective, economical and practical, easy to apply, easy to control the dose, and good compliance. And the vaccination system can effectively prevent illegal and repeated use, and reduce the risk of infection among medical staff. At present, the injection method commonly used at home and abroad is to use an injection needle made of stainless steel to pierce the vaccinator so as to inject the vaccine or medicine. Needlestick injuries, and the dangers they pose, and more. Worldwide, 5 needlestick injuries occur in every 100 injections. On the contrary, needle-free immunization technology uses special equipment to i...

Claims

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Application Information

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IPC IPC(8): A61K39/145A61K9/00A61P31/16A61M5/30A61M5/315A61D7/00
CPCA61D7/00A61K9/0021A61K39/12A61K2039/575A61M5/30A61M5/31505A61M5/31511A61M2202/30C12N2760/16034A61M2202/0007
Inventor 刘晓峰任天宇王希良许振国刘洪王鋮邢丽张良艳杨鹏辉赵忠鹏段跃强
Owner CHANGCHUN HAIJIYA BIOTECH CO LTD
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