Rabies vaccine needle-free injection system and application

A rabies vaccine and needle-free injection technology, which is applied to the needle-free injection rabies vaccine system and application field, can solve the problems of insufficient immune response and immune protection, large side effects, and large amount of antigen, so as to improve compliance and prevent secondary utilization. , the effect of reducing the amount of antigen

Inactive Publication Date: 2016-10-12
CHANGCHUN HAIJIYA BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Existing vaccine immunizations mostly use needled muscle or subcutaneous parts for immunization, which has the practical problems of large amount of antigen, insufficient immune response and immune protection, and large side effects

Method used

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  • Rabies vaccine needle-free injection system and application
  • Rabies vaccine needle-free injection system and application
  • Rabies vaccine needle-free injection system and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] Embodiment 1, the preparation of needle-free injection ampoule

[0067] The present invention will be described in detail below in conjunction with the accompanying drawings and embodiments.

[0068] Such as figure 1 A. figure 1 As shown in B, the needle-free injection ampoule of prepacked vaccine or medicine provided by the present invention includes a tube body 1, a needle-free syringe joint 2, a power push rod 3, a jetting port 4, a stop rod 5, A sealing cap 6 and a sealing lock block 7; wherein, the tube body 1 is used for pre-filling a fixed and precise dose of vaccine or medicine, the needle-free syringe connector 2 is integrally arranged at one end of the tube body 1, and the power push rod 3 is controlled by the tube body The other end of 1 is slidingly arranged in the tube body 1, and closes the tube body 1; the injection port 4 is set in the needleless syringe joint 2, which has a stop groove 8, and the injection port 4 passes through the stop slot 8 and the...

Embodiment 2

[0079] Embodiment 2, the application of needle-free injection rabies vaccine system

[0080] The needle-free injection rabies vaccine system of this embodiment includes a needle-free injection ampoule filled with 0.5-2.5 IU rabies vaccine and a matching needle-free injector.

[0081] 1. Exploration of the injection depth of the needle-free rabies vaccine system

[0082] Fill the ink aqueous solution instead of the vaccine into the needle-free injection ampoule prepared in Example 1 to obtain the needle-free injection ampoule filled with the ink aqueous solution.

[0083] The aqueous ink solution is to filter the common blue-black ink with a filter membrane with a pore size of 0.22um, collect the filtrate and dilute it with water for injection to obtain an aqueous ink solution with a concentration of 1%.

[0084] Connect the needle-free injection ampoule filled with 0.1ml ink aqueous solution to the MIT needle-free syringe (Jiangsu Chengyu Miite Medical Technology Co., Ltd., p...

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Abstract

The invention discloses a rabies vaccine needle-free injection system and application. The rabies vaccine needle-free injection system comprises a container filled with a rabies vaccine and a readable carrier. Content recorded in the readable carrier includes that needle-free injection dosage of the rabies vaccine is not larger than the standard dosage of the rabies vaccine. Experiments prove that when a needle-free injection ampoule and a needle-free syringe are combined and used for immunization, the antigen dosage only accounts for part of a traditional intramuscular injection antigen dosage, and the same or higher ineutralizing antibody level can be generated. It is further indicated that a needle-free immune mode is an ideal means capable of being selected by the rabies immunization vaccine.

Description

technical field [0001] The invention relates to the field of medicine, especially the field of infectious diseases. More specifically, it relates to a needle-free injection rabies vaccine system and application. It is suitable for all kinds of rabies vaccine immunization and vaccination. Background technique [0002] At present, injection needles made of stainless steel are commonly used both at home and abroad to inject drugs or vaccines into the human body. Needle injections are known to pose risks such as: accidental punctures by healthcare workers, fear of needles and pain for vaccinators, and cross-contamination. Therefore, the safety of injection has become a hot concern in clinical practice. It also promotes the birth of a new drug injection or vaccination method that can replace the traditional needle injection method and avoid the above-mentioned hazards-needle-free injection method. By avoiding the use of needles, it can overcome the fear of needles of vaccinat...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/205A61M5/303A61P31/14A61K9/00
CPCA61K9/0021A61K39/12A61K2039/575A61M5/30C12N2760/20134
Inventor 任天宇王希良刘晓峰许振国刘洪王鋮邢丽张良艳杨鹏辉段跃强赵忠鹏
Owner CHANGCHUN HAIJIYA BIOTECH CO LTD
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