32results about How to "Lessen the pain of injections" patented technology

A compound medicine containing kurarinol, prostaglandic E1 and aspirin is prepared through including the kurarinol and prostaglandin E1 by 6-0-malto-beta-cyclodextrin, mixing, adding others, and preparing the freeze dried powder injection. It can be used for treating cancers, cardiovascular and cerebrovascular diseases and hepatitis. Its advantages are sure curative effect, and no toxic by-effect.

The invention belongs to the technical field of pharmaceutical preparations, and concretely relates to temsirolimus for injection and a preparation method thereof. The preparation method comprises dissolving a prescribed amount of temsirolimus and an anti-oxidant in anhydrous alcohol, mixing uniformly, adding a dispersant, re-mixing uniformly, freeze drying and removing the ethanol to obtain the temsirolimus. The preparation provided by the invention is few in prescription component; and the preparation method is convenient and easy, improves disadvantages of complex technology in present prescription, and greatly minimizes components such as alcohols and the like that may cause injection pain, thereby being relatively safe and reliable.

The present invention relates to high quality motherwort injection and its preparation process. The present invention proposes the HPLC fingerprint standard, and has determined characteristic matters in motherwort injection, optimized technological process, raised injection consistency and high and stable product quality.

The invention discloses a compound ceftiofur suspension emulsion injection, which comprises the following components in percentage by mass: 1.5 to 15 percent of ceftiofur hydrochloride, 1.5 to 15 percent of magnolia flower oil, 1 to 10 percent of surfactant, 3 to 30 percent of oil for injection, 0.1 to 1 percent of antioxidant, 0.01 to 0.1 percent of thickening agent, and the balance of water for injection, wherein the sum of the mass percents of the components is 100 percent. The compound ceftiofur suspension emulsion injection has simple operation for the preparation method, strong antibacterial property and lasting pharmacological effect, and avoids stresses caused by multi-time administration of conventional formulations to animals; furthermore, the preparation cost is much lower than that of an oil suspension, and the compound ceftiofur suspension emulsion injection has a very high popularization and application value.

The invention relates to the formulation of pharmaceutical compositions of etanercept. The invention also relates to methods of removing buffer and of formulating pharmaceutical compositions of etanercept.

A compound isopropylphenol injection containing local anesthetic contains proportionally isopropylphenol, the local anesthetic chosen from procaine, lidocaine, etc, the refined plant oil for injection, emulsifier, isotonic regulator, antioxidant, pH regulator and the water for injection. Its preparing process is also disclosed.

The invention discloses a tissue injection for improving aging. The tissue injection comprises the following substances, by mass concentration: 5 to 10mg/ml of collagen, 4 to 8 mg/ml of sodium hyaluronate, 5 to 10 mg/ml of tranexamic acid, 10 to 30 mg/ml of glutathione, 2 to 4 mg/ml of L-carnosine, 0.1 to 0.2 mg/ml of glycine, 0.2 to 0.4 mg/ml of proline, 5 to 10 mg/ml oflidocaine, and 9mg/ml of sodium chloride. The collagen and the sodium hyaluronate are added, so that protein and hyaluronic acid lost by an organism can be quickly supplemented, tissue lacuna is formed to stimulate autologous tissue hyperplasia, plump tissue of an injection part is promoted, the L-carnosine, the tranexamic acid and the glutathione have anti-inflammatory and anti-oxidation functions, the adaptability of skin to the environment is improved, and the chromatosis is reduced. The skin is healthier and shiny. And the glycine and the proline increase protein synthesis nutrition, so that nutrition can be provided for skin tissue cells, and the beautifying effect is more durable. In the injection process, due to the fact that lidocaine is added, injection pain and discomfort can be reduced.

The invention discloses a modified amylase-based nanometer helical oil phase-triggered quick-release material and a preparation method thereof. The preparation method comprises that amylase which can form a helical structure is modified, then is coated with hydrophobic vein center action drugs such as propofol and forms a helical brain localization quick-release system. The helical brain localization quick-release system has good dispersibility in a water phase, has uniform particle sizes, has a stable particle size for a long time, does not leak propofol easily, can be stored easily, and reduces propofol injection pain. After being triggered by the oil phase, the modified amylase-based nanometer helical oil phase-triggered quick-release material can fast release propofol and is conducive to fast release of propofol at the blood-brain barrier. The preparation method has simple processes, adopts the nontoxic raw materials, does not produce toxic substances in production, carries out disinfection easily and can be industrialized easily.

The invention discloses a brucellosis vaccine needle-free injection system and application. The brucellosis vaccine needle-free injection system comprises a container filled with a brucellosis vaccine and a readable carrier. Content recorded in the readable carrier includes that needle-free injection dosage of the brucellosis vaccine is not larger than the standard dosage of the brucellosis vaccine. Experiments prove that when a needle-free injection ampoule and a needle-free syringe are combined and used for immunization, the antigen dosage only accounts for part of a traditional intramuscular injection antigen dosage, and the same or better immune effect can be achieved. It is further indicated that a needle-free immune mode is an ideal strategy capable of being selected by the brucellosis immunization vaccine.

The invention relates to the technical field of medical cosmetic instruments, in particular to a split type multi-needle-tube injection device, wherein a base and a needle table are designed in a split mode, a containing groove is formed in one end of the base, the needle table is inserted into the containing groove and packaged and fixed to the containing groove through glue, a plurality of parallel needle grooves are formed in the side face of the needle table, needle tubes are fixed in the needle grooves, and the other end of the base communicates with an injector which communicates with the needle tubes. Compared with the prior art, the split type multi-needle-tube injection device has the advantages that by means of the split type design of the base and the needle table, the mode thatneedle tubes are directly and vertically inserted and assembled in a traditional process is changed, needle tube assembling efficiency can be greatly improved, and assembling precision can be improved; gaps between the needle tubes can be finer, the distance between the needle tubes is shortened, and injection pain is relieved; the number of the needle tubes can be adjusted according to the number of the needle grooves, injection devices with different requirements for the number of the needle tubes in different use scenes can be produced as required, production is flexible, flexibility is achieved easily, and product applicability is improved.

The invention discloses a novel vecuronium bromide freeze-dried preparation and a preparation method thereof. The novel preparation comprises the main components of vecuronium bromide, a freeze-dried excipient, polyethylene glycol playing a role in re-dissolving assistance, vitamin E playing a role in anti-oxidation, and glycerol serving as an isotonic regulator. According to the formula, the vecuronium bromide is developed into the novel freeze-dried preparation, and the process is simple. The novel vecuronium bromide freeze-dried preparation can improve the pH value of re-dissolved preparation solution to make the pH value reach or be close to the physiological pH range of blood, avoids or reduces stimulations caused by the preparation to a blood vessel, alleviates injection pains, and simultaneously can ensure that a medicament compound is fully dissolved to prevent insoluble substances from causing side effect injuries to a body.

The invention discloses a treatment device for a medical injector and a use method of the treatment device, and belongs to the field of medical injections. The treatment device can integrate a piston assembly, a medicine bottle and a needle head, when the piston assembly moves downwards to conduct injection operation, liquid medicine is injected into the body of a patient through extrusion of a film on the medicine bottle, so that it is guaranteed that the liquid medicine does not make contact with the external environment in the whole process of injection operation, and pollution is avoided; meanwhile, when the injection operation is finished, through ordered conversion of space leakproofness and non-leakproofness in the piston assembly, the film is driven to expand outwards, the medicine bottle falls off from the position where the medicine bottle is clamped by the film currently, the clamping relation cannot be recovered, and the needle head is almost impossible to be aligned to the positions of an upper cover and a lower cover of the medicine bottle for the second time, so that the situation that the injector is used for the second time is effectively avoided; and in the process of injection, mutual matching between bandage sending out and bandage receiving is adopted to prevent secondary use.

The invention belongs to the technical field of medicines and particularly relates to a propofol injection and a preparation method of the injection. A formula of the propofol injection comprises an active ingredient: propofol, and auxiliary materials: structured triglyceride, egg yolk lecithin, an isoosmotic adjusting agent, water for injection and sodium hydrogen phosphate. The propofol injection has the characteristics that the propofol injection is free from a metal ion complexing agent, namely edetate disodium; soybean oil is substituted by structured triglyceride in the auxiliary materials; and sodium hydroxide is substituted by sodium hydrogen phosphate to regulate a pH (potential of hydrogen) value. The propofol injection has the advantages of reasonable compatibility, small stimulation and good stability, and has effects that an injection pain feeling of the traditional propofol injection in a clinical application is relieved and an anesthesia effect of the traditional propofol injection is improved. In addition, the encapsulation efficiency of the propofol injection is better after long-time placement, and quality parameters such as a content and relevant substances of the propofol injection comply with quality standards.

The invention discloses a rabies vaccine needle-free injection system and application. The rabies vaccine needle-free injection system comprises a container filled with a rabies vaccine and a readable carrier. Content recorded in the readable carrier includes that needle-free injection dosage of the rabies vaccine is not larger than the standard dosage of the rabies vaccine. Experiments prove that when a needle-free injection ampoule and a needle-free syringe are combined and used for immunization, the antigen dosage only accounts for part of a traditional intramuscular injection antigen dosage, and the same or higher ineutralizing antibody level can be generated. It is further indicated that a needle-free immune mode is an ideal means capable of being selected by the rabies immunization vaccine.

The invention discloses an influenza vaccine needle-free injection system and application. The influenza vaccine needle-free injection system comprises a needle-free injection ampoule filled with a vaccine which is monovalent or multivalent, and the HA content of each vaccine in monovalent or multivalent vaccines is 3-15 microgramme. Experiments prove that when the influenza vaccine needle-free injection system is used for immunization, the antigen dosage only accounts for part of a traditional intramuscular injection antigen dosage, and the same or higher HI titer can be generated. It is further indicated that a needle-free immune means is an ideal means capable of being selected by the influenza immunization vaccine.