Compound vitamin B injection and preparation method thereof

A technology of complex vitamins and injections, which is applied in the direction of drug combinations, pharmaceutical formulas, active ingredients of heterocyclic compounds, etc., can solve the problems of complex processes and high production costs, and achieve the effects of simple processes, saving raw material costs, and reducing process steps

Active Publication Date: 2021-07-13
河南益华动物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the complicated process and the problem of vitamin B in the preparation process of compound vitamin B injection 2 -The problem of high production cost caused by 5'-sodium phosphate, the present invention provides a compound vitamin B injection with low cost, high efficiency, stable quality and meeting the quality standards of veterinary drugs and its preparation method

Method used

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  • Compound vitamin B injection and preparation method thereof
  • Compound vitamin B injection and preparation method thereof
  • Compound vitamin B injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The composition of each 1000mL complex vitamin B injection is: 9.8g vitamin B 1 , 0.98g vitamin B 2 , 0.98g vitamin B 6 , 14.7g nicotinamide, 0.49g sodium d-pantothenate, 0.05g EDTA-2Na, 20mL triethanolamine, and the balance is water for injection.

[0024] The preparation of above-mentioned compound vitamin B injection comprises the following contents:

[0025] Step 1: Add the cosolvent triethanolamine to 60% of the prescription water for injection, the pH value of the gained water for injection is 11.2, add vitamin B 2 , fully stirred until dissolved to obtain solution 1;

[0026] Step 2: Take the prescribed amount of vitamin B in turn 1 , Vitamin B 6 , nicotinamide, sodium d-pantothenate and EDTA-2Na were added to 20% of the prescribed amount of water for injection, and stirred until dissolved to obtain solution 2;

[0027] Step 3: Add solution 2 to solution 1, add the remaining amount of water for injection to obtain a mixed solution, and adjust the pH value o...

Embodiment 2

[0030] The composition of each 1000mL complex vitamin B injection is: 10.02g vitamin B 1 , 1.02g Vitamin B 2 , 1.02g Vitamin B 6 , 15.3g nicotinamide, 0.51g sodium d-pantothenate, 0.15g EDTA-2Na, 40mL triethanolamine, and the balance is water for injection.

[0031] The preparation of above-mentioned compound vitamin B injection comprises the following contents:

[0032] Step 1: Add the cosolvent triethanolamine to 60% of the prescription water for injection, the pH value of the resulting water for injection is 11.7, add vitamin B 2 , fully stirred until dissolved to obtain solution 1;

[0033] Step 2: Take the prescribed amount of vitamin B in turn 1 , Vitamin B 6 , nicotinamide, sodium d-pantothenate and EDTA-2Na were added to 20% of the prescribed amount of water for injection, and stirred until dissolved to obtain solution 2;

[0034] Step 3: Add solution 2 to solution 1, add the remaining amount of water for injection to obtain a mixed solution, and adjust the pH va...

Embodiment 3

[0037] The composition of each 1000mL complex vitamin B injection is: 10g vitamin B 1 , 1g vitamin B 2 , 1g vitamin B 6 , 15g nicotinamide, 0.5g sodium d-pantothenate, 0.1g EDTA-2Na, 30mL triethanolamine, and the balance is water for injection.

[0038] The preparation of above-mentioned compound vitamin B injection comprises the following contents:

[0039] Step 1: Add the cosolvent triethanolamine to 60% of the prescription water for injection, the pH value of the resulting water for injection is 11.4, add vitamin B 2 , fully stirred until dissolved to obtain solution 1;

[0040] Step 2: Take the prescribed amount of vitamin B in turn 1 , Vitamin B 6 , nicotinamide, sodium d-pantothenate and EDTA-2Na were added to 20% of the prescribed amount of water for injection, and stirred until dissolved to obtain solution 2;

[0041] Step 3: Add solution 2 to solution 1, add the remaining amount of water for injection to obtain a mixed solution, and adjust the pH value of the mi...

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Abstract

The compound vitamin B injection of the present invention is composed of 9.8-10.02g vitamin B per 1000mL 1 , 0.98~1.02g Vitamin B 2 , 0.98~1.02g Vitamin B 6 , 14.7~15.3g nicotinamide, 0.49~0.51g sodium d-pantothenate, 0.05~0.15g EDTA-2Na, 20~40mL triethanolamine, and the balance is water for injection. Specifically, add triethanolamine to 60% of the prescription water for injection, add vitamin B 2 , to get solution one; turn vitamin B 1 , Vitamin B 6 , Niacinamide, and D-pantothenate sodium are added to 20% of the prescribed amount of water for injection to obtain solution 2; mix solution 2 and solution 1 and adjust the pH value to 3.8-5.2, and add the remaining amount of water for injection; filter, fill, Sterilize. The compound vitamin B injection prepared by the invention has low raw material cost, high efficiency, stable quality and meets the quality standard of veterinary drugs.

Description

technical field [0001] The invention belongs to the technical field of veterinary drugs, and in particular relates to vitamin B compound injection and a preparation method thereof. Background technique [0002] At present, in the preparation process of compound vitamin B injection, Tween-80 is usually used as a cosolvent and the process is complicated, such as Chinese invention patent (publication number CN1879626A) discloses a kind of compound vitamin B injection and its preparation method: (1) Vitamin B 1 Add to water for injection, stir to dissolve; (2) vitamin B 6 Dissolve in water for injection, mix with the solution in step (1), add ammonium bethanechol chloride to dissolve; (3) dissolve nicotinamide in water for injection, add anhydrous vitamin B 2 -5'-Sodium phosphate was stirred to dissolve; (4) Sodium D-pantothenate and disodium edetate were dissolved in water for injection, mixed evenly, and mixed with the solution prepared in step (3); (5) Tween-80 was dissolv...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K47/18A61K31/51A61K31/525A61K31/4415A61K31/455A61P3/02
CPCA61K9/0019A61K9/08A61K31/4415A61K31/455A61K31/51A61K31/525A61K47/18A61K47/183A61P3/02
Inventor 李国辉刘徽焦金英刘兵李自波孙少辉王彦辉彭丽孟蕾张盼盼
Owner 河南益华动物药业有限公司
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