Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Salmon calcitonin nano liposome injection and preparation method thereof

A technology of salmon calcitonin and nano-liposomes, which is applied in the field of medicine, can solve the problems of affecting the quality of medicines, poor patient compliance, and affecting treatment effects, and achieve the effects of reducing drug dosage, small side effects, and alleviating injection pain

Inactive Publication Date: 2012-01-25
傅苗青
View PDF0 Cites 4 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Peptide drug aqueous solution is generally unstable, which will affect the quality of the drug, and its side effects are large, especially the pain of intravenous injection, and the patient's compliance is poor, which affects the therapeutic effect.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Salmon calcitonin nano liposome injection and preparation method thereof
  • Salmon calcitonin nano liposome injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Salmon calcitonin nanoliposome injection, which is a powder injection, is a sterile nano freeze-dried preparation obtained by coating salmon calcitonin with a pharmaceutically acceptable biological carrier, including the following raw materials in parts by weight:

[0028] 1 part of salmon calcitonin, 10 parts of human serum albumin, 1 part of citric acid, 6 parts of mannitol.

[0029] The method for preparing the above-mentioned salmon calcitonin nano liposome injection is as follows:

[0030] (1) Dissolve salmon calcitonin in a mixed solvent of isopropanol and ethanol with a volume ratio of 3:1, add phosphate buffer with a pH value of 3.9-4.5 until it is completely dissolved, and adjust its pH value to 3.9- 4.5, sealed and stored, is the organic phase;

[0031] (2) Disperse human serum albumin and citric acid in water for injection, add phosphate buffer with a pH value of 3.9-4.5, constant volume, adjust the pH value to 3.9-4.5, and stir to dissolve into the water ph...

Embodiment 2

[0036] Salmon calcitonin nanoliposome injection, which is a powder injection, is a sterile nano freeze-dried preparation obtained by coating salmon calcitonin with a pharmaceutically acceptable biological carrier, including the following raw materials in parts by weight:

[0037] 1 part of salmon calcitonin, 15 parts of human serum albumin, 2 parts of citric acid, 10 parts of mannitol.

[0038] The method for preparing the above-mentioned salmon calcitonin nano liposome injection is as follows:

[0039] (1) Dissolve salmon calcitonin in a mixed solvent of isopropanol and ethanol with a volume ratio of 3:1, add phosphate buffer with a pH value of 3.9-4.5 until it is completely dissolved, and adjust its pH value to 3.9- 4.5, sealed and stored, is the organic phase;

[0040] (2) Disperse human serum albumin and citric acid in water for injection, add phosphate buffer with a pH value of 3.9-4.5, constant volume, adjust the pH value to 3.9-4.5, and stir to dissolve into the water ...

Embodiment 3

[0045] Salmon calcitonin nanoliposome injection, which is a powder injection, is a sterile nano freeze-dried preparation obtained by coating salmon calcitonin with a pharmaceutically acceptable biological carrier, including the following raw materials in parts by weight:

[0046] 1 part of salmon calcitonin, 4 parts of human serum albumin, 0.5 part of sodium citrate, 3 parts of aspartic acid.

[0047] The method for preparing the above-mentioned salmon calcitonin nano liposome injection is as follows:

[0048] (1) Dissolve salmon calcitonin in a mixed solvent of isopropanol and ethanol with a volume ratio of 3:1, add phosphate buffer with a pH value of 3.9-4.5 until it is completely dissolved, and adjust its pH value to 3.9- 4.5, sealed and stored, is the organic phase;

[0049] (2) Disperse human serum albumin and sodium citrate in water for injection, add phosphate buffer solution with a pH value of 3.9-4.5, constant volume, adjust the pH value to 3.9-4.5, and stir to d...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to the technical field of medicine, and discloses a cloxacillin sodium liposome preparation for injection and a preparation method thereof. The cloxacillin sodium liposome preparation is a powder injection, and is a sterile nano freeze-drying preparation which is prepared by coating salmon calcitonin with a pharmaceutically-acceptable biological carrier. The cloxacillin sodium liposome preparation comprises the following raw materials in parts by weight: 1 part of salmon calcitonin, 4-15 parts of pharmaceutically-acceptable biological carrier, 0.5-2 parts of stabilizer and 2-10 parts of freeze-drying protective agent. The product disclosed by the invention has high stability and a low side effect, can not be cracked as a result of dehydration, fusion, generation of ice crystals and the like in the freeze-drying process, and can keep a good entrapment rate after hydration and refusion, thereby facilitating the transportation and storage of the product.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a salmon calcitonin nano liposome injection and a preparation method. Background technique [0002] Peptides are a class of substances with a wide range of physiological activities in the human body. Salmon calcitonin is one of the most effective peptide drugs, and it is the drug of choice for the treatment of osteoporosis in humans. It is a polypeptide consisting of 32 amino acids. In humans it is a hormone secreted by the parafollicular cells of the thyroid. The role of salmon calcitonin is mainly through the impact on target organs such as bones, kidneys, and intestines, and by antagonizing with parathyroid hormone (PTH), it can protect bones, inhibit bone reabsorption, and maintain blood calcium levels. balance. Clinically, it is mostly used to treat osteoporosis and hypercalcemia caused by various reasons. According to the latest research data, 90% of patients who have...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61P19/10A61P25/00A61K38/23A61P5/22A61P5/16A61K9/19A61K9/127
Inventor 傅苗青
Owner 傅苗青
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com