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Needle-free injection rabies virus vaccine system and application

A virus vaccine, needle-free injection technology, applied in the field of infectious diseases and medicine, can solve the problems of insufficient immune protection, weak immune response, large amount of antigen, etc. Effect

Inactive Publication Date: 2016-08-10
INNER MONGOLIA HUAXI BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Most of the vaccination methods use needled muscle or subcutaneous parts for immunization, which has the practical problems of large amount of antigen, weak immune response, insufficient immune protection, and large side effects

Method used

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  • Needle-free injection rabies virus vaccine system and application
  • Needle-free injection rabies virus vaccine system and application
  • Needle-free injection rabies virus vaccine system and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0076] Embodiment 1, the preparation of needle-free injection ampoule

[0077] The present invention will be described in detail below in conjunction with the accompanying drawings and embodiments.

[0078] Such as figure 1 A. figure 1 As shown in B, the needle-free injection ampoule of prepacked vaccine or medicine provided by the present invention includes a tube body 1, a needle-free syringe joint 2, a power push rod 3, a jetting port 4, a stop rod 5, A sealing cap 6 and a sealing lock block 7; wherein, the tube body 1 is used for pre-filling a fixed and precise dose of vaccine or medicine, the needle-free syringe connector 2 is integrally arranged at one end of the tube body 1, and the power push rod 3 is controlled by the tube body The other end of 1 is slidingly arranged in the tube body 1, and closes the tube body 1; the injection port 4 is set in the needleless syringe joint 2, which has a stop groove 8, and the injection port 4 passes through the stop slot 8 and the...

Embodiment 2

[0089] Embodiment 2, needle-free injection canine virus vaccine system and application

[0090] The needle-free injection canine virus vaccine system of this embodiment includes a needle-free injection ampoule filled with 1 / 5-1 times the standard dose of canine virus vaccine and a matching needle-free injector.

[0091] The standard dose of canine virus vaccine is the intramuscular injection dose of 1 canine virus vaccine, and the intramuscular injection dose of 1 canine virus vaccine is reflected by the virus content.

[0092] For different canine virus vaccines, the volume and virus content of 1 canine virus vaccine intramuscular injection dose are different:

[0093] The attenuated rabies virus content of 1 canine virus vaccine intramuscularly injected is ≥10 5.0 LD50 / 0.03ml, the volume is generally 2.0ml;

[0094] The attenuated canine distemper virus content of 1 dose of canine virus vaccine intramuscularly injected is ≥10 4.5 TCID50 / 0.1ml, the volume is generally 2.0m...

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Abstract

The invention discloses a needle-free injection rabies virus vaccine system and application. The needle-free injection rabies virus vaccine system comprises a container filled with rabies virus vaccine and a readable carrier. The readable carrier comprises recording content that the needle-free injection dosage of the rabies virus vaccine is not larger than the standard dosage of the rabies virus vaccine. Experiments prove that when a needle-free injection ampoule and a needle-free injector are combined for immunization, the same or higher immunization effect can be produced through the antigen with the dosage only being a part of the dosage of traditional intramuscular injection antigen. The experiments further show that the needle-free immunization mode is an optional ideal strategy for immunizing the rabies virus vaccine.

Description

technical field [0001] The invention relates to the field of medicine, especially the field of infectious diseases. More specifically, it relates to a needle-free canine virus vaccine system and application. It is suitable for various types of canine virus vaccine immunization and vaccination. Background technique [0002] At present, stainless steel injection needles are commonly used at home and abroad to inject drugs or vaccines into humans or animals. As we all know, the injection of needles will bring a lot of inconvenience, and the safety of injection has become a hot issue in clinical operations. Therefore, a drug or vaccination method that can replace the traditional needle injection method was born-needle-free injection. In recent years, needle-free injection technology is in a stage of rapid development, from traditional high-pressure needle-free injection with large trauma to today's low-pressure needle-free injection with small trauma, which promotes the develo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M5/28A61M5/303A61M5/20A61M5/50A61M5/31A61D7/00
CPCA61M5/28A61D7/00A61M5/20A61M5/3007A61M5/3015A61M5/31A61M5/504A61M2005/2006A61M2005/2026A61M2005/5046A61M2202/30A61M2202/0007
Inventor 连梦瑶任天宇王林叶王欢孙治华李敏王鋮杨晓岚木其尔
Owner INNER MONGOLIA HUAXI BIOTECH
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