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Application of esculetin to preparation of medicine for preventing and treating Dengue fever type II virus infection

A technique for esculin and virus infection, applied in the directions of antiviral agents, pharmaceutical formulations, resistance to vector-borne diseases, etc., to achieve the effect of preventing and treating dengue fever infection

Active Publication Date: 2016-10-26
GUANGZHOU UNIVERSITY OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report that esculin has anti-dengue virus activity in the current literature reports.

Method used

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  • Application of esculetin to preparation of medicine for preventing and treating Dengue fever type II virus infection
  • Application of esculetin to preparation of medicine for preventing and treating Dengue fever type II virus infection
  • Application of esculetin to preparation of medicine for preventing and treating Dengue fever type II virus infection

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0034] Example 1: (injection)

[0035] Take escinolide 1000mg, add citric acid 1000mg, sodium citrate 500mg, sodium chloride 1800mg, add 1000ml of water for injection, stir to dissolve, sterilize and filter, potting, steam at 100°C for 15 minutes Sterilize and make each 2mg / 2ml injection for injection.

example 2

[0036] Example 2: (capsules)

[0037] Take escin 5000mg and 4000mg microcrystalline cellulose, 500mg sodium carboxymethyl starch, 400mg sodium lauryl sulfate and other auxiliary materials, fully mix, use the roller compaction method for dry granulation, and then mix with an appropriate amount of magnesium stearate , filled into 3# hollow capsules, made into capsules with a specification of 100mg / grain for oral use.

example 3

[0038] Example 3: (tablet)

[0039] Get escinolide 5000mg and 4000mg starch, 200mg cross-linked PVP, 300mg sodium carboxymethyl starch and mix uniformly, use 75% ethanol solution of 5% PVP as binding agent, make soft material, granulate with 18 mesh sieves, 60 After drying at ℃ for 1 hour, add an appropriate amount of talcum powder after granulation at 20 mesh, mix well, and compress into tablets to make tablets with a specification of 100 mg / tablet for oral use.

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PUM

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Abstract

The invention relates to application of esculetin to preparation of a medicine for preventing and treating Dengue fever type II virus infection. In the application, the medicine is composed of the esculetin and pharmaceutically acceptable auxiliary materials, wherein the mass percent content of the esculetin in the medicine is 10%-60%. The medicine provided by the invention has the effect of resisting Dengue fever type II viruses and can be used for preventing Dengue fever infection.

Description

technical field [0001] The invention relates to medical products containing organic active ingredients, in particular to medicines containing coumarin compounds. Background technique [0002] Dengue virus (dengue virus) belongs to Flaviviridae and Flavivirus genus in classification. Including 4 different serotypes, namely type Ⅰ, Ⅱ, Ⅲ, Ⅳ dengue virus. According to the severity of the disease, it can be clinically divided into dengue fever, dengue hemorrhagic fever and dengue shock syndrome. Dengue fever spreads quickly and has a high incidence rate. Dengue hemorrhagic fever and dengue shock syndrome are severe and have high fatality rates. With the acceleration of global economic integration and the continuous warming of the climate, coupled with the acceleration of the spread of mosquitoes and the widening of the distribution range, the disease has spread rapidly around the world. At present, about 50 million to 100 million people in the world are infected with dengue vi...

Claims

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Application Information

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IPC IPC(8): A61K31/366A61P31/14
CPCA61K31/366Y02A50/30
Inventor 李耿赖小平吴建国
Owner GUANGZHOU UNIVERSITY OF CHINESE MEDICINE