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Nymphaea candida presl total flavonoid extract as well as preparation method and application thereof

A technology of water lily flower and total flavonoids, which is applied in the direction of drug combination, medical formula, plant raw materials, etc., can solve the problems of water lily flower separation and purification process blank, and achieve the effect of easy industrial production, good anti-hepatitis effect, and low cost

Active Publication Date: 2016-10-26
XINJIANG INST OF MATERIA MEDICA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The present invention provides an extract of total flavonoids from water lily flower and its preparation method and its application in the preparation of drugs for preventing and treating liver damage, which overcomes the above-mentioned deficiencies in the prior art, and can effectively solve the problem of blank separation and purification process of water lily flower

Method used

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  • Nymphaea candida presl total flavonoid extract as well as preparation method and application thereof
  • Nymphaea candida presl total flavonoid extract as well as preparation method and application thereof

Examples

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Embodiment 1

[0024] Example 1, the total flavonoid extract of water lily flower contains flavonoids in a weight percentage of 50% to 80%, isostrictiniin in a weight percentage of 1.2% to 3.0%, and a pyroside content in a weight percentage of 9.0% to 16.0%. , the weight percentage of the content of ascarin is 4.5% to 8.0%.

Embodiment 2

[0025] Example 2, the water lily flower total flavonoids extract contains 50% or 80% by weight of flavonoids, 1.2% or 3.0% by weight of isostrictiniin content, and 9.0% or 16.0% by weight of pyroside content , the weight percent of the content of ascarin is 4.5% or 8.0%.

Embodiment 3

[0026] Example 3, the water lily flower total flavonoids extract is obtained according to the following preparation method: the first step, choose water lily flower as raw material, water lily flower is added to ethanol aqueous solution and boiled and then refluxed for 1 to 3 times, after extraction, the extracts were combined and Concentrate to obtain a primary extract; the second step, dilute the primary extract with deionized water to obtain the first dilution, the first dilution is adsorbed with a macroporous resin column, and after adsorption, deionized water is used successively with a volume percentage of 30% The ethanol and volume percentage are 50% to 70% ethanol elution, and the collection volume percentage is 50% to 70% ethanol eluent, and the ethanol eluent is concentrated to obtain the secondary extract; the third step, the secondary extract The paste is diluted with deionized water to obtain the second dilution, the second dilution is adsorbed by a polyamide resin...

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Abstract

The invention relates to the technical field of nymphaea candida presl extracts and relates to a nymphaea candida presl total flavonoid extract as well as a preparation method and application thereof. The nymphaea candida presl total flavonoid extract is prepared from the following components in percentage by weight: 50 percent to 80 percent of flavonoid, 1.2 percent to 3.0 percent of isostrictiniin, 9.0 percent to 16.0 percent of nicotiflorin and 4.5 percent to 8.0 percent of astragalin. The invention provides a method for separating and purifying the nymphaea candida presl total flavonoid extract; the flavonoid components are extracted from the nymphaea candida presl by a method with combination of macroporous resin and polyamide resin. The nymphaea candida presl total flavonoid extract has the advantages that the cost is low, the pollution is avoided, and the industrial production is easy to implement; meanwhile, the nymphaea candida presl total flavonoid extract has a good anti-hepatitis effect, is high in effectiveness and low in toxicity, and can be applied to prevention and treatment of liver injury.

Description

technical field [0001] The invention relates to the technical field of water lily flower extract, and relates to a water lily flower total flavonoid extract, a preparation method and application thereof. Background technique [0002] Liver damage caused by various factors such as viruses, alcohol, and drugs is a common clinical disease. Severe or persistent liver damage can lead to liver fibrosis, and even liver cirrhosis, liver cancer and other diseases. Prevention and treatment of liver damage is an important aspect of clinical liver disease treatment. In recent decades, it has become a hot spot in the research and development of drugs for liver disease to search for active parts and active ingredients that can prevent and treat liver damage from traditional Chinese medicine, national medicine and natural medicine. Water lily flower is the dry flower bud of Nymphaea candidaPresl, a plant of the genus Nymphaea. It has the effects of clearing heat, detoxifying, calming and c...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/62A61P1/16
CPCA61K36/62A61K2236/333A61K2236/39A61K2236/51A61K2236/53A61K2236/55
Inventor 赵军徐芳吉腾飞李晨阳陈燕詹羽姣
Owner XINJIANG INST OF MATERIA MEDICA
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