Thermosensitive gel injection wrinkle remover

A temperature-sensitive gel and anti-wrinkle agent technology, applied in the field of cosmetic materials, can solve the problems of anti-wrinkle effect regulation, re-plasticity, etc., and achieve the effect of enhancing anti-wrinkle effect, improving smoothness, and good safety

Active Publication Date: 2019-01-15
NANJING SKY LONG PHARMA +4
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are no reports on the use of poloxamer thermosensitive gels to solve the problems of remodeling, anti-wrinkle effect regulation, and material recovery in injection wrinkle removal.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] P407 gel

[0022] (1) Gel composition: Poloxamer 407 (Poloxamer, P407), 30% by mass; the rest is deionized water.

[0023] (2) Performance index: gelation temperature (T sol-gel ) is 15°C, the gel liquefaction temperature (T gel-sol ) is 9°C; at 30°C, the modulus of elasticity reaches 30kPa; the weight percentage of water in the gel is 70%.

[0024] (3) General wrinkle removal operation process:

[0025] (a) Temperature-sensitive gel liquefaction: the gel components should be placed in the refrigerator (4°C) for more than 10 minutes to freeze and liquefy; at the same time, the injection equipment used for injection should also be placed at the same temperature (4°C) to keep it in a low temperature state;

[0026] (b) Conventional anti-wrinkle injection: operate according to the conventional anti-wrinkle injection method, and inject the liquefied gel under the wrinkle part of the skin that needs to be filled;

[0027] (c) Liquefaction shaping: apply ice packs (or other...

Embodiment 2

[0048] P407-PBS gel

[0049] (1) Gel composition: Poloxamer 407 (Poloxamer, P407), 18% by mass; the rest is phosphate buffer saline (PBS).

[0050] (2) Performance index: gelation temperature (T sol-gel ) is about 20°C, and the gel liquefaction temperature (T gel-sol ) is lower than 15°C; the elastic modulus is about 8kPa at 30°C; the weight percentage of water in the gel is 82%.

[0051] The various wrinkle removal operations are the same as in Example 1 (3) general wrinkle removal operation process, (5) reshaping control operation, (6) re-injection operation, (7) partial extraction operation, (8) cancel filling The wrinkle removal operation etc. are all the same, and will not be repeated here.

Embodiment 3

[0053] P407-PEG gel

[0054] (1) Gel composition: Poloxamer 407 (Poloxamer, P407) 22% by mass; polyethylene glycol (PEG, molecular weight 15000-20000), 1.1% by mass; the rest is deionized water.

[0055] (2) Performance index: gelation temperature (T sol-gel ) is about 25°C, and the gel liquefaction temperature (T gel-sol ) is lower than 15°C; at 30°C, the elastic modulus reaches about 6kPa; the weight percentage of water in the gel is 78%.

[0056] The various wrinkle removal operations are the same as in Example 1 (3) general wrinkle removal operation process, (5) reshaping control operation, (6) re-injection operation, (7) partial extraction operation, (8) cancel filling The wrinkle removal operation etc. are all the same, and will not be repeated here.

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Abstract

The invention relates to a cosmetic material, in particular to a temperature-sensitive gel injection wrinkle eliminating agent which is used for subcutaneous injection of a human body to eliminate wrinkles. The temperature-sensitive gel injection wrinkle eliminating agent is a temperature-sensitive gel material prepared from, by mass, a temperature-sensitive polymer material 6-60%, an auxiliary material 0-20% and a solvent 40-94%. The temperature-sensitive gel injection wrinkle eliminating agent has the advantages that temperature-sensitive gel is adopted as an injection filling agent in the wrinkle eliminating process and is cured or liquefied by utilizing temperature change after filling, injection and form adjustment are promoted, supplemented injection and filling quantity decrease are also promoted, and the wrinkle eliminating operation process is greatly promoted; cured form can be freely adjusted after filling of the filling agent, the flatness of skin surface is improved, and a wrinkle eliminating effect is improved; the temperature-sensitive gel material has good biocompatibility, does not poduce foreign body reaction and is good in safety.

Description

technical field [0001] The invention relates to a cosmetic material, in particular to a temperature-sensitive gel injectable anti-wrinkle agent for injecting into the subcutaneous of human body to eliminate wrinkles. Background technique [0002] Skin is composed of three parts: epidermis, dermis, and subcutaneous tissue. As we age, skin wrinkles begin to appear. Skin wrinkles are generally divided into three stages: the first stage of fine lines, the second stage of dynamic wrinkles, and the third stage of static wrinkles. [0003] Skin fine lines generally appear after the age of 25, the skin begins to age, the epidermis and dermis become thinner, the skin moisture content decreases, and the skin gradually loses elasticity and fine lines appear. Generally, it is repaired by sun protection and supplemented with nutrients, such as A acid, fruit acid, L-C, etc., or eliminated by methods such as magneto-optical waves and pulsed light. [0004] Dynamic wrinkles are wrinkles ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/86A61K8/81A61K8/04A61Q19/08
CPCA61K8/042A61K8/8129A61K8/86A61K2800/91A61Q19/08
Inventor 黄为民陈红梅魏民蒋旭彤
Owner NANJING SKY LONG PHARMA
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