A kind of Thymol nano particle wash-free hand sanitizer and preparation method thereof
A disposable hand sanitizer and nanoparticle technology, applied in the field of hand sanitizer, can solve the problems of thymol being unstable and insoluble in water, and achieve the effects of protecting the skin from drying, wide antibacterial spectrum, and stable performance.
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Embodiment 1
[0018] A kind of Thymol nano particle disposable hand sanitizer proposed by the present invention, its raw material comprises by weight percentage: Thymol nano particle essence 0.5%, carbomer 0.3%, triethanolamine 0.05%, 1,2-propanediol 0.15% %, 0.05% hydroxyethyl urea, 0.15% sodium lactate, 0.05% essence, 0.15% food coloring, and the balance is distilled water.
Embodiment 2
[0020] A kind of Thymol nano particle free hand sanitizer proposed by the present invention, its raw material comprises by weight percentage: 1.5% of thymol nano particle essence, 0.1% of carbomer, 0.09% of triethanolamine, 0.05% of 1,2-propanediol %, hydroxyethyl urea 0.15%, sodium lactate 0.05%, essence 0.15%, food coloring 0.05%, and the balance is distilled water.
[0021] The preparation method of thymol nanoparticle essence is as follows: mix lecithin and cholesterol evenly, then add thymol and mix evenly, dry, then add phosphate buffered saline solution to shake, ultrasonicate in water bath, and stand in a dark environment to obtain thymol nanoparticle Particle essence.
Embodiment 3
[0023] A kind of Thymol nano particle free hand sanitizer proposed by the present invention, its raw material comprises by weight percentage: Thymol nano particle essence liquid 1%, carbomer 0.2%, triethanolamine 0.07%, 1,2-propanediol 0.1% %, 0.1% hydroxyethyl urea, 0.1% sodium lactate, 0.1% essence, 0.1% food coloring, and the balance is distilled water.
[0024] The preparation method of thymol nanoparticle essence is as follows: 2 parts of lecithin chloroform solutions with a concentration of 10 mg / mL and 2 parts of cholesterol chloroform solutions with a concentration of 2 mg / mL are mixed evenly in parts by volume, and rotary steamed to obtain a phospholipid film. Then add 2 parts of thymol methanol solution with a concentration of 1 mg / mL and mix evenly, dry with nitrogen, vacuumize for 12 hours, then add 5 parts of phosphate buffered saline solution for shaking for 15 minutes, ultrasonic in a water bath for 10 minutes, and stand in a dark environment for 2 hours to obtai...
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