A kind of Thymol nano particle wash-free hand sanitizer and preparation method thereof

A disposable hand sanitizer and nanoparticle technology, applied in the field of hand sanitizer, can solve the problems of thymol being unstable and insoluble in water, and achieve the effects of protecting the skin from drying, wide antibacterial spectrum, and stable performance.

Active Publication Date: 2019-06-04
ANHUI KIWI BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Based on the technical problems existing in the background technology, the present invention proposes a thymol nanoparticle-free hand sanitizer and a preparation method thereof, which effectively solve the instability and water-insoluble problems of thymol, and the obtained hand sanitizer has broad-spectrum, Efficient bactericidal effect, good killing effect on Escherichia coli and Staphylococcus aureus, good stability, no irritation to the skin, and moisturizing skin care effect

Method used

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  • A kind of Thymol nano particle wash-free hand sanitizer and preparation method thereof
  • A kind of Thymol nano particle wash-free hand sanitizer and preparation method thereof

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Embodiment 1

[0018] A kind of Thymol nano particle disposable hand sanitizer proposed by the present invention, its raw material comprises by weight percentage: Thymol nano particle essence 0.5%, carbomer 0.3%, triethanolamine 0.05%, 1,2-propanediol 0.15% %, 0.05% hydroxyethyl urea, 0.15% sodium lactate, 0.05% essence, 0.15% food coloring, and the balance is distilled water.

Embodiment 2

[0020] A kind of Thymol nano particle free hand sanitizer proposed by the present invention, its raw material comprises by weight percentage: 1.5% of thymol nano particle essence, 0.1% of carbomer, 0.09% of triethanolamine, 0.05% of 1,2-propanediol %, hydroxyethyl urea 0.15%, sodium lactate 0.05%, essence 0.15%, food coloring 0.05%, and the balance is distilled water.

[0021] The preparation method of thymol nanoparticle essence is as follows: mix lecithin and cholesterol evenly, then add thymol and mix evenly, dry, then add phosphate buffered saline solution to shake, ultrasonicate in water bath, and stand in a dark environment to obtain thymol nanoparticle Particle essence.

Embodiment 3

[0023] A kind of Thymol nano particle free hand sanitizer proposed by the present invention, its raw material comprises by weight percentage: Thymol nano particle essence liquid 1%, carbomer 0.2%, triethanolamine 0.07%, 1,2-propanediol 0.1% %, 0.1% hydroxyethyl urea, 0.1% sodium lactate, 0.1% essence, 0.1% food coloring, and the balance is distilled water.

[0024] The preparation method of thymol nanoparticle essence is as follows: 2 parts of lecithin chloroform solutions with a concentration of 10 mg / mL and 2 parts of cholesterol chloroform solutions with a concentration of 2 mg / mL are mixed evenly in parts by volume, and rotary steamed to obtain a phospholipid film. Then add 2 parts of thymol methanol solution with a concentration of 1 mg / mL and mix evenly, dry with nitrogen, vacuumize for 12 hours, then add 5 parts of phosphate buffered saline solution for shaking for 15 minutes, ultrasonic in a water bath for 10 minutes, and stand in a dark environment for 2 hours to obtai...

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Abstract

The invention discloses a thymol nano-particle waterless hand sanitizer which is prepared from the following raw materials by weight: 0.5 to 1.5 percent of a thymol nano-particle essence, 0.1 to 0.3 percent of carbomer, 0.05 to 0.09 percent of triethanolamine, 0.05 to 0.15 percent of 1,2-propanediol, 0.05 to 0.15 percent of hydroxyethyl urea, 0.05 to 0.15 percent of sodium lactate, 0.05 to 0.15 percent of essence, 0.05 to 0.15 percent of an edible pigment, and the balance of distilled water. According to the thymol nano-particle waterless hand sanitizer, the problems that thymol is unstable and cannot dissolve in water are solved effectively; the obtained hand sanitizer has a broad-spectrum and efficient bactericidal effect, has good killing effect on both escherichia coli and staphylococcus aureus, has good stability, is free of skin irritation, and has the efficacies of moisturizing and skin caring.

Description

technical field [0001] The invention relates to the technical field of hand sanitizers, in particular to a thymol nanoparticle-free hand sanitizer and a preparation method thereof. Background technique [0002] At present, the commonly used fungicide components at home and abroad are synthetic organic small molecules, such as dichlorophenoxychlorophene and chlorhexidine acetate. Although these fungicides have a strong bactericidal effect, it has been reported that dichlorophenoxychlorophene has a carcinogenic risk, especially for newborns, which will cause distortion. It is safer to use herbal plant extracts as disinfectants. [0003] Thymol is found and extracted from thyme. Thymol is a very effective antibacterial agent with low toxicity. It has bactericidal and fungicidal effects on oral and throat mucous membranes, and has antiseptic effects on carious cavities. disease and otitis. However, thymol is insoluble in water and unstable, which limits its use in daily life...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K8/98A61K8/9789A61K8/9794A61K8/34A61K8/365A61K8/41A61K8/42A61K8/81A61K8/02A61Q19/10A61Q19/00A61Q17/00A61P31/02
CPCA61K8/0245A61K8/345A61K8/347A61K8/365A61K8/41A61K8/42A61K8/8147A61K8/97A61K8/988A61K2800/413A61K2800/5922A61K2800/652A61Q17/005A61Q19/00A61Q19/10
Inventor 王攀胡衎缪慧李军配张国庆张百成张学鹏
Owner ANHUI KIWI BIOTECH CO LTD
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