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Crocin-artichoke compound chewable tablets and preparation method thereof

A technology of saffron and artichoke, which is applied in the direction of medical formula, drug combination, medical preparations containing active ingredients, etc., can solve the problems of ineffective relief and treatment of liver disease, great stimulation and damage to human body, etc., and improve bioavailability degree, cardiovascular protection, surface area increase effect

Pending Publication Date: 2016-11-16
HUAQIAO UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, liver diseases are generally treated after the onset of the disease, mainly using methods such as drug therapy, chemotherapy, surgical resection, and surgical transplantation. These methods are more harmful to the human body and cannot effectively relieve and treat liver diseases

Method used

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  • Crocin-artichoke compound chewable tablets and preparation method thereof

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Effect test

Embodiment 1

[0023] A composite chewable tablet of saffron and artichoke, whose raw materials are calculated in parts by mass, including 0.5 parts of artichoke freeze-dried powder, 0.1 part of saffron, 20 parts of lactose, 5 parts of glucose, 2 parts of mannitol, and 4 parts of vitamin C , 0.3 part of magnesium stearate, its preparation method comprises:

[0024] 1) Wash the artichoke stems and leaves, remove the silt and mold adsorbed on the surface, dry them after washing, crush to a particle size of 20 mesh, add 10 times the amount of water, extract with 250W microwave for 60s, and inhale the extract into the external circulation After concentrating in a vacuum concentrator to 20-25 degrees Baume, use D101 macroporous adsorption resin for separation and purification: load the sample according to the volume flow rate of 4BV / h, elute with 3BV of 50% ethanol, and the elution rate is 4BV / h. The obtained eluate was inhaled into the external circulation decompression concentrator again and co...

Embodiment 2

[0031] A compound chewable tablet of saffron and artichoke, its raw materials are calculated in parts by mass, including 2 parts of freeze-dried artichoke powder, 0.5 parts of saffron, 25 parts of lactose, 7 parts of glucose, 4 parts of mannitol, and 6 parts of vitamin C , 0.3 part of magnesium stearate, its preparation method comprises:

[0032] 1) Wash the artichoke stems and leaves, remove the silt and mold adsorbed on the surface, dry them after washing, crush to a particle size of 20 mesh, add 15 times the amount of water, extract with 300W microwave for 120s, and inhale the extract into the external circulation After concentrating in a vacuum concentrator to 20-25 degrees Baume, use AB-8 type macroporous adsorption resin for separation and purification: according to the volume flow rate of 4BV / h, the sample is loaded, 4BV of 50% ethanol is eluted, and the elution rate is 4BV / h h, the obtained eluate was sucked into the external circulation decompression concentrator agai...

Embodiment 3

[0039] A saffron and artichoke compound chewable tablet, the raw materials of which are calculated in parts by mass, include 1.5 parts of artichoke freeze-dried powder, 0.3 parts of saffron, 23 parts of lactose, 6 parts of glucose, 3 parts of mannitol, and 5 parts of vitamin C , 0.3 part of magnesium stearate, its preparation method comprises:

[0040] 1) Wash the artichoke stems and leaves, remove the silt and mold adsorbed on the surface, dry them after washing, crush to a particle size of 20 mesh, add 20 times the amount of water, extract with 200W microwave for 180s, and suck the extract into the external circulation Decompression concentrator, 5BV of 50% ethanol for elution, the elution rate is 4BV / h, the eluate obtained is sucked into the external circulation decompression concentrator again and concentrated to 40-45 degrees Baume, then freeze-dried for 72h to obtain Freeze-dried artichoke powder, wherein the content of active ingredient cynic acid is 5.6%;

[0041] 2) ...

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Abstract

The invention discloses crocin-artichoke compound chewable tablets and a preparation method thereof. The crocin-artichoke compound chewable tablets are prepared from, by mass, 0.4-3 parts of artichoke freeze-dried powder, 0.05-0.6 part of crocin, 18-28 parts of lactose, 3-8 parts of glucose, 1-5 parts of mannitol, 3-8 parts of vitamin C, 0.2-0.4 part of magnesium stearate and a bonding agent, wherein an absolute ethyl alcohol solution of 3% polyvinylpyrrolidone is adopted as the bonding agent. The compound chewable tablets prepared through the method are natural reddish brown, do not contain saccharose, are cool, sour and sweet in mouthfeel and have the fresh smell; the crocin and the artichoke both have the effects of protecting the liver, promoting metabolism and reducing cholesterol and are combined in the form of the chewable tablets, and then the health-care effects of the crocin and the artichoke are further improved.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, and in particular relates to a compound chewable tablet of saffron and artichoke and a preparation method thereof. Background technique [0002] The liver is an important organ that maintains the metabolism of the human body. It plays an important role in biosynthesis, biotransformation, detoxification, secretion, excretion, and immunity. Emotions, sleep, diet, and even drugs all affect the catharsis function of the liver. With the change of lifestyle and the improvement of nutritional level, liver disease has become one of the major diseases that threaten health. Its causes are various, and it is a long-term accumulation and latent process. Once the liver is damaged, it is difficult to fully recover. At present, liver diseases are generally treated after the onset of the disease, mainly using methods such as drug therapy, chemotherapy, surgical resection, and surgical transplantation. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/28A61K9/20A61P1/16A61P3/06A61P3/00A61K31/194
CPCA61K9/0056A61K9/2018A61K31/194A61K36/28A61K47/26A61K2236/331A61K2236/55A61K2300/00
Inventor 汤须崇寇馨月邓爱华刘希敏雷廷平韦若帆徐祥
Owner HUAQIAO UNIVERSITY
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