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Licorice particles and traditional Chinese medicine preparation of licorice particles

A technology of licorice and granules, which is applied in the direction of medical formulas, medical preparations containing active ingredients, plant raw materials, etc., can solve problems such as the inability to meet real-time analysis of multi-species, multi-batch samples, physical injury of inspectors, information feedback lag, etc. Achieve the effect of process parameters and easy control, high accuracy and stable process parameters

Active Publication Date: 2016-11-16
GUANGDONG YIFANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the quality of traditional Chinese medicine formula granules will also be restricted by detection methods. The traditional determination of moisture and ethanol extracts in licorice granules requires several hours with reference to the pharmacopoeia, and the operation is more complicated.
The main chemical components of licorice granules are liquiritin and glycyrrhizic acid. As quality control indicators, the traditional method uses high performance liquid chromatography, etc., which often requires complicated pretreatment of samples, consumes a lot of reagents, and pollutes the environment. Physical damage to inspectors, delayed information feedback, unable to meet the needs of real-time analysis of multi-variety and multi-batch samples in the process of large-scale production of granule enterprises

Method used

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  • Licorice particles and traditional Chinese medicine preparation of licorice particles
  • Licorice particles and traditional Chinese medicine preparation of licorice particles
  • Licorice particles and traditional Chinese medicine preparation of licorice particles

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Preparation of licorice granules: take licorice decoction pieces, add water to decoct 3 times, add 8 times the amount of water each time, and heat and decoct for 1.5 hours each time; Mesh sieve filtration; spray drying under the conditions of air inlet temperature 185°C, material pump speed 400 rpm, outlet air temperature 95°C, and air supply temperature 40°C to obtain spray dry powder; Roller motor frequency 40HZ, feeding motor frequency 45HZ, oil cylinder pressure 20bar under the condition of dry granulation to obtain licorice granules with a particle size of 40 mesh.

Embodiment 2

[0038] Preparation of traditional Chinese medicine preparation containing licorice granules: take licorice decoction pieces, add water to decoct 3 times, add 8 times the amount of water each time, heat and decoct for 1.5 hours each time; combine the medicinal liquids, concentrate the filtrate to a clear paste with a relative density of 1.08, Filter while hot with a 350-mesh sieve; spray-dry under the conditions of air inlet temperature 185°C, material pump speed 400 rpm, outlet air temperature 95°C, and air supply temperature 40°C to obtain spray-dried powder; Aperture 1.50mm, roller motor frequency 40HZ, feeding motor frequency 45HZ, oil cylinder pressure 20bar under the conditions of dry granulation to obtain licorice granules with a particle size of 40 mesh; mix 200g licorice granules with 85g maltodextrin, add an appropriate amount of magnesium stearate, Mix well and press into 1000 tablets.

Embodiment 3

[0040] A method for rapidly detecting the moisture content of licorice granules based on near-infrared spectroscopy, specifically comprising the following steps:

[0041] a. Take licorice granule samples, a total of 101 batches, about 3g each, grind into fine powder, put it into a stoppered glass sample bottle, place it on a near-infrared scanner for scanning, collect spectra, scanning conditions: scanning range 4000 -12000cm -1 , number of scans: 32 times, resolution 8cm -1 , the background is subtracted in real time during the scanning process, and 3 spectra are collected for each sample to obtain the following figure 1 The near-infrared original absorption spectrum figure of 101 batches of licorice granules shown;

[0042] At the same time, according to the standard method specified in the 2015 edition of the Chinese Pharmacopoeia, its moisture content was determined by the drying method. About 2 g of licorice granules that were ground into fine powder were spread flat in...

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Abstract

The invention discloses licorice particles and a traditional Chinese medicine preparation of licorice particles. The licorice particles can be prepared by comprising the following steps: taking licorice decoction pieces, adding water for decocting the material for 2-3 times, adding 5-10 times of water for 1-2 hours each time; merging liquid medicine, concentrating a filtrate to a clear paste with relative density of 1.02-1.12, filtrating the clear paste with a 250-350-mesh sieve while hot; taking the clear paste for spray drying to obtain the dry powder; and granulating by a dry method to obtain the licorice particles with 16-40 meshes. The preparation technology of the licorice particles is simple, technological parameter is easily controlled, and a detection method has the advantages of scientific performance, rapidity, and strong operationality.

Description

technical field [0001] The invention belongs to the technical field of traditional Chinese medicine preparations, in particular to a licorice granule and a traditional Chinese medicine preparation thereof. Background technique [0002] Licorice is the dry root and rhizome of Glycyrrhiza uralensis Fisch., Glycyrrhiza inflata Bat. or Glycyrrhiza glabra L. of the leguminous plant Glycyrrhiza uralensis Fisch. Heat-clearing and toxic substances removing, eliminating phlegm and relieving cough, relieving spasm and relieving pain, harmonizing the effects of various medicines. [0003] Traditional Chinese medicine granules are a series of traditional Chinese medicine products made of traditional Chinese medicine decoction pieces that meet the processing specifications, which are extracted, concentrated, dried, and granulated by modern industry. The new form of decoction pieces replaces the decoction pieces of traditional Chinese medicine for clinical syndrome differentiation and tr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/484A61K9/16G01N21/359G01N21/3563
CPCA61K9/16A61K36/484A61K2236/331A61K2236/39A61K2236/51G01N21/3563G01N21/359
Inventor 王闽予朱德全霍文杰刘丽萍陈向东谭登平程学仁
Owner GUANGDONG YIFANG PHARMA
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