Synthesizing method of medical intermediate 2-acetyl-4-(2-methyl)pyridine

Abstract

The invention relates to a method for synthesizing a pharmaceutical intermediate 2-acetyl-4-(2-methyl)pyridine. Using pyridine as a raw material, under the action of methanol as a solvent, acetylation and Methylation produces 2-acetyl-4-(2-methyl)pyridine. The synthesis method of the pharmaceutical intermediate 2-acetyl-4-(2-methyl)pyridine of the present invention is simple, efficient and safe in operation, and is very practical in specific production.

Description

technical field [0001] The invention relates to a method for synthesizing a pharmaceutical intermediate 2-acetyl-4-(2-methyl)pyridine. Background technique [0002] 2-Acetyl-4-(2-methyl)pyridine is the starting material for the synthesis of many drugs, especially the important intermediates of many pyridine compounds. There is no report on the synthesis of this compound in China. Contents of the invention [0003] The object of the present invention is to overcome above-mentioned deficiency, provides a kind of synthetic method of the pharmaceutical intermediate 2-acetyl-4-(2-methyl)pyridine of a kind of simple, efficient, safe operation. [0004] The purpose of the present invention is achieved like this: [0005] A method for synthesizing a pharmaceutical intermediate 2-acetyl-4-(2-methyl)pyridine, using pyridine as a raw material, under the action of solvent methanol, through acetylation and methylation respectively at a temperature of 120°C-150°C , Generate 2-acetyl-4...

AI Technical Summary

Problems solved by technology

[0002] 2-Acetyl-4-(2-methyl)pyridine is the starting material for the synthesis of many drugs, especially the important intermediates of many pyridine compounds. There is no report on the synthesis method of this compound in China at present.