Magnetic nano pharmaceutical complex and preparation method application thereof

A magnetic nano-composite technology, used in drug combinations, pharmaceutical formulations, anti-tumor drugs, etc., can solve problems such as emphasis, and achieve the effects of low long-term toxicity, enhanced killing effect, and increased stability

Active Publication Date: 2016-12-14
THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0007] CN103289400A discloses a kind of ferric oxide / polypyrrole composite material, and it is made up of ferric oxide and polypyrrole, and wherein Fe in the ferric oxide / polypyrrole composite material 3 o 4 The particle size distribution of the particles is 5-30nm, the saturation magnetization of the ferroferric oxide / polypyrrole composite material is 30-70emu / g, and the electrical conductivity is 5-20S / cm. However, this invention only focuses on the ferric oxide / polypyrrole Magnetic and Conductive Properties of Polypyrrole Composite

Method used

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  • Magnetic nano pharmaceutical complex and preparation method application thereof
  • Magnetic nano pharmaceutical complex and preparation method application thereof
  • Magnetic nano pharmaceutical complex and preparation method application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0089] In this example, the magnetic nano drug complex is prepared by the following method, specifically including the following steps:

[0090] (1) 1. the chitosan quaternary ammonium salt shown in the formula (I) that the molecular weight of 2g is 100,000Da is dissolved in 50mL deionized water, is placed in the there-necked flask, reaction system is logical nitrogen 30min, and oil bath is heated up to 102 ℃, Get the reaction system a;

[0091] ②Take 0.1459g of FeCl 3 ·6H 2 O with 0.071g FeCl 2 4H 2 O was dissolved in 2 mL of hydrochloric acid solution with a concentration of 1 mol / L to obtain solution b;

[0092] ③ Inject solution B into reaction system a in step (1), slowly add 15 mL of concentrated ammonia water dropwise until pH = 10; reflux at 80-120°C for 40 minutes to obtain reaction system c;

[0093] ④ After cooling the reaction system c in step (3) to room temperature, move all the reaction solution to a dialysis bag, and dialyze with deionized water at 20°C to...

Embodiment 2

[0103] In this example, the magnetic nano drug complex is prepared by the following method, specifically including the following steps:

[0104] (1) 1. the chitosan quaternary ammonium salt shown in the formula (I) that the molecular weight of 2g is 100,000Da is dissolved in 50mL deionized water, is placed in the there-necked flask, reaction system is logical nitrogen 30min, and oil bath is heated up to 102 ℃, Get the reaction system a;

[0105] ②Take 0.1459g of FeCl 3 ·6H 2 O with 0.071g FeCl 2 4H 2 O was dissolved in 2 mL of hydrochloric acid solution with a concentration of 1 mol / L to obtain solution B;

[0106] ③ Inject solution b into reaction system a in step (1), slowly add 15 mL of concentrated ammonia water dropwise to pH = 10; reflux at 80-120°C for 40 minutes to obtain reaction system c;

[0107] ④ After cooling the reaction system c in step (3) to room temperature, move all the reaction solution to a dialysis bag, and dialyze with deionized water at 20°C to 35...

Embodiment 3

[0115] In this example, the magnetic nano drug complex is prepared by the following method, specifically including the following steps:

[0116] (1) ① Dissolve 1.5 g of chitosan quaternary ammonium salt represented by formula (I) with a molecular weight of 100,000 Da in 50 mL of deionized water, place it in a three-necked flask, pass nitrogen to the reaction system for 20 minutes, and heat up the oil bath to 110 ° C , get the reaction system a;

[0117] ②Take 0.1459g of FeCl 3 ·6H 2 O with 0.1075g of FeCl 2 4H 2 O was dissolved in 4 mL of hydrochloric acid solution with a concentration of 1 mol / L to obtain solution b;

[0118] ③ Inject solution b into reaction system a in step (1), slowly add 15 mL of concentrated ammonia water dropwise to pH = 10; reflux at 80-120°C for 30 minutes to obtain reaction system c;

[0119] ④ After cooling the reaction system c in step (3) to room temperature, move all the reaction solution to a dialysis bag, and dialyze with deionized water a...

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Abstract

The invention provides magnetic nano pharmaceutical complex and a preparation method application thereof. The magnetic nano pharmaceutical complex comprises ferroferric oxide nanoparticle doped polypyrrole nano-carrier, pharmaceutical DAPT carried on the surface of the polypyrrole nano-carrier, and hyaluronic acid adsorbed to the surface of the polypyrrole nano-carrier that carries the pharmaceutical DAPT. The magnetic nano pharmaceutical complex has high ability to carry the pharmaceutical DAPT, good stability and small particle size, has good penetrating capacity and uniform particle size, has significant magneto-thermal slow control, has long-cycle effect in vivo, has no evident cytotoxicity, has low long-term toxicity and good biocompatibility, has significant killing effect on tumor stem cells, and has better killing effect particularly in connection with magneto-thermal therapy; the preparation method of the complex is simple, has mild conditions and low cost and is easy to popularize and apply.

Description

technical field [0001] The invention belongs to the technical field of nano-medicine, and relates to a magnetic nano-medicine complex and a preparation method and application thereof. Background technique [0002] DAPT ((2S)-N-[N-(3,5-difluorophenylacetyl)-L-alanyl]-2-phenylglycine tert-butyl ester), as a new type of antitumor drug, has been Widespread concern. The molecular formula of DAPT (GSI-IX) is C 23 h 26 f 2 N 2 o 4 , with a molecular weight of 432.46, is an inhibitor of γ-secretase, which can selectively inhibit the function of γ-secretase and specifically block the Notch pathway, so as to achieve the purpose of tumor treatment. Some recent studies have shown that blocking the Notch pathway with DAPT can reduce the proportion of tumor stem cells in tumor cells, thereby achieving the purpose of tumor treatment, so DAPT is often used as a specific inhibitor of tumor stem cells. However, due to poor water solubility and lack of specific targeting of DAPT drug mo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/51A61K47/34A61K47/36A61K38/05A61K31/216A61K41/00A61P35/00
CPCA61K9/5146A61K9/5161A61K31/216A61K38/05A61K41/0052A61K2300/00
Inventor 陈春英唐敬龙周会鸽刘佳明
Owner THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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