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A circRNA marker, kit and gene chip for schizophrenia diagnosis

A schizophrenia and gene chip technology, applied in the field of circRNA markers and gene chips for the diagnosis of schizophrenia, can solve the problems of lack of specific biomarkers, unclear pathological mechanism, lack of objective indicators in clinical diagnosis, etc.

Active Publication Date: 2021-04-23
张理义
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Problems solved by technology

[0006] The etiology of schizophrenia is complex, the pathological mechanism is unclear, and the lack of specific biomarkers results in the lack of objective indicators for clinical diagnosis and increases the rate of clinical misdiagnosis. Therefore, to explore the specific biomarker cirRNA for the diagnosis and efficacy observation of schizophrenia, It is of great significance and value for the diagnosis, treatment and relapse prevention of schizophrenia

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  • A circRNA marker, kit and gene chip for schizophrenia diagnosis
  • A circRNA marker, kit and gene chip for schizophrenia diagnosis
  • A circRNA marker, kit and gene chip for schizophrenia diagnosis

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Embodiment Construction

[0033] 1. Research object

[0034] Case group: From August 2014 to October 2015, patients were continuously admitted to the outpatient department and psychiatric ward of the 102nd Hospital of the People's Liberation Army. Inclusion criteria: ①Meet the diagnostic criteria for schizophrenia in the 4th edition of the American Diagnostic and Statistical Manual of Mental Disorders (DSM-IV); ②First-episode patients or did not take antipsychotic drugs 3 months before enrollment. Exclusion criteria: ① suffering from other mental diseases; ② suffering from physical or nervous system diseases such as traumatic brain injury; ③ having a history of alcoholism or drug abuse; ④ having a history of blood transfusion within 1 month before enrollment; ⑤ within 3 months before enrollment Patients who have used MECT without convulsions. A total of 102 people were enrolled, including 44 males and 58 females, age age.

[0035] Control group: staff from the 102nd Hospital of the People's Liber...

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Abstract

The invention belongs to the field of biotechnology, and relates to a circRNA marker and a kit for schizophrenia diagnosis and curative effect evaluation. The present invention provides a circRNA marker for the diagnosis of schizophrenia, including hsa_circRNA_101835, hsa_circRNA_101836, hsa_circRNA_102101, hsa_circRNA_102315, hsa_circRNA_103102, hsa_circRNA_103704 and hsa_circRNA_104597, and the primer sequences of the above seven circRNAs are as follows: 14; probes for the above seven circRNAs are also provided, and the probe sequences are shown in SEQ ID NO.15 to SEQ ID NO.21. The present invention also provides a circRNA marker for evaluating the efficacy of anti-schizophrenia drugs. The beneficial effect of the present invention is that it provides biomarkers for schizophrenia and circRNA biomarkers for evaluating the curative effect of antipsychotic drugs for the first time. After clinical verification, it has high specificity and sensitivity, and has a high diagnostic reference value. As a specific biomarker for schizophrenia, circRNA will bring about revolutionary changes in the diagnosis and treatment of schizophrenia.

Description

technical field [0001] The invention belongs to the field of biotechnology, and relates to a circRNA marker, a kit and a gene chip for the diagnosis of schizophrenia. Background technique [0002] Schizophrenia (SZ) is a major psychiatric disease and one of the most serious mental disorders. It usually occurs in young and middle-aged people, and often has special obstacles and mental activities such as thinking, perception, emotion and behavior. Disharmony with the environment, the prevalence rate of the world's population is about 1%. Schizophrenia is characterized by positive symptoms such as hallucinations, delusions, psychomotor excitement, and disordered thinking forms, and / or by emotional bluntness, apathy, social withdrawal, and decreased will. Negative symptoms such as negative symptoms are the main clinical features, causing serious damage to the patient's cognitive, emotional, behavioral and social functions. Schizophrenia has a high disability rate, relapse rate ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/6883C12N15/11C40B40/06
CPCC12Q1/6883C12Q2600/118C12Q2600/158
Inventor 张理义
Owner 张理义