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Method for preparing cinnamon extract, cinnamon extract and composition and application of cinnamon extract

A technology of cinnamon extract and composition, which is applied in the preparation of cinnamon extract, its composition and application, and the field of cinnamon extract, which can solve the problems of limited application and achieve the effect of improving related diseases and reducing high blood pressure

Inactive Publication Date: 2016-12-21
武汉正百泰谷药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, transdermal absorption and intravenous injection greatly limit the clinical application

Method used

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  • Method for preparing cinnamon extract, cinnamon extract and composition and application of cinnamon extract
  • Method for preparing cinnamon extract, cinnamon extract and composition and application of cinnamon extract
  • Method for preparing cinnamon extract, cinnamon extract and composition and application of cinnamon extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0066] Preparation method of cinnamon extract

[0067] Crush cinnamon to the size of a thumb cap (about 5-15cm in diameter), add 2 times the amount of water and soak for 12 hours, collect the supernatant extract, then add 6 times the amount of 70% ethanol to reflux for extraction three times, each time for 1 hour, and combine the extracts , filtered, recovered ethanol and concentrated under reduced pressure to a thick paste with a relative density of 1.18-1.20 (60° C.) for NMR and GCMS analysis and made into tablets.

Embodiment 2

[0069] NMR and GC-MS analysis of water-ethanol cinnamon extract

[0070] NMR and gas chromatography-mass spectrometry sample preparation method: Weigh 500 mg of dried cinnamon extract into a 2 ml sample bottle, add 1.5 ml deuterated acetonitrile (CD3CN), and magnetically stir at room temperature (22 degrees) for 12 hours. Afterwards centrifugation was continued at 7000 rpm for 5 minutes. Take out the supernatant, filter it through a 0.2 micron filter, inject it into a 5mm nuclear magnetic resonance tube, and send it to the nuclear magnetic resonance test. Another part was sent to gas chromatography-mass spectrometry for detection. The results are shown in Figure 1-5.

[0071] Instruments used: Nuclear Magnetic Resonance BRUKER AV600-III (600M); Gas Chromatography-Mass Spectrometer: Agilent7890A.

[0072] The relative ratio determination of each component in the cinnamon extract: adopt the nuclear magnetic resonance spectrum integration data that obtains in the extract of ac...

Embodiment 3

[0085] Compositions containing cinnamon extract for antihypertensive use

[0086] The subjects of primary hypertension were selected according to the diagnostic criteria of hypertension drawn up by WHO / ISH, and those with secondary hypertension, no history of diabetes, and abnormal thyroid function were excluded. Essential hypertension is a chronic disease characterized by blood pressure persistently exceeding 140 / 90mmHg. The systolic blood pressure of our selected patients is in the range of 140-154mmHg, the diastolic blood pressure is in the range of 90-100mmHg, male and female aged 54-76 years, with a history of hypertension for more than 10 years, long-term use of antihypertensive drugs such as Beta receptor blockers, etc. (7 cases, 5 cases of normal control).

[0087] The dose of the composition of cinnamon extract is 150 mg / tablet, and each person takes two tablets per day in two divided doses, that is, the total amount of 300 mg.

[0088] All patients stopped taking a...

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Abstract

The invention relates to the technical field of cinnamon extracting, in particular to a method for preparing cinnamon extract, the cinnamon extract and a composition and application of the cinnamon extract. The method for preparing the cinnamon extract includes the following steps that a raw cinnamon material is added into a water-based solvent, and the mixture is soaked and extracted; the soaked-and-extracted raw cinnamon material is added into ethyl alcohol, and reflux extraction is carried out; the soaking and extracting liquid and the reflux extraction liquid are mixed. The cinnamon extract is the water-alcohol extract, the water-alcohol extract is prepared from about 75% of cinnamyl aldehyde, about 15% of dibenzofuran-2-ketone, about 2% of 2-methoxycinnamaldehyde and smaller than 1% of other compounds. By means of the cinnamon extract, blood pressure of high blood pressure patients can be reduced, particularly, the systolic pressure can be reduced, normal blood pressure is not obviously influenced, and the obvious toxic and side effects do not exist; related diseases caused by high blood pressure can be improved while high blood pressure is reduced through the cinnamon extract.

Description

technical field [0001] The invention relates to the technical field of cinnamon extraction, in particular to a preparation method of cinnamon extract, cinnamon extract, composition and application thereof. Background technique [0002] Cinnamon has a long history as a traditional Chinese medicine and an important seasoning. It is recorded in Chinese medicine books that it nourishes the fire at the door of life, calms the liver and unblocks the four veins, draws the fire back to the original, has the effects of strengthening the heart, invigorating the stomach, expelling wind and evil, and relieving vomiting. [0003] Cinnamon is a plant in the Lauraceae family. It is a commonly used traditional Chinese medicine and is also often used in food. It is a common medicinal and edible plant. It is hot in nature, sweet and pungent in taste, and has the functions of nourishing yang, warming kidney, dispelling cold, dredging pulse and relieving pain. Clinically, it is often used to r...

Claims

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Application Information

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IPC IPC(8): A61K36/54A61K9/20A61P9/12
CPCA61K36/54A61K9/2054A61K2236/331A61K2236/333
Inventor 王正本朱蓓莉张莹陈少军杨俊杰
Owner 武汉正百泰谷药业有限公司
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