System for multi-index combined diagnosis of ovarian cancer and/or non-ovarian malignant tumors

A technology for malignant tumors and ovarian cancer, applied in the field of tumor diagnosis, can solve the problems of high blood pressure, low specificity, difficult tumor diagnosis effect, etc.

Inactive Publication Date: 2016-12-21
GUANGXI MEDICAL UNIVERSITY
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Problems solved by technology

Although it has higher sensitivity than other tumor markers, CA125 can also increase in pelvic inflammatory disease, endometriosis, and uterine fibroids, and its specificity is low
In addition to CA125, people have also found many valuable tumor markers for the diagnosis of ovarian cancer, but it is difficult to achieve a good diagnostic effect on tumors by detecting one marker alone

Method used

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  • System for multi-index combined diagnosis of ovarian cancer and/or non-ovarian malignant tumors
  • System for multi-index combined diagnosis of ovarian cancer and/or non-ovarian malignant tumors
  • System for multi-index combined diagnosis of ovarian cancer and/or non-ovarian malignant tumors

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Embodiment Construction

[0045] The present invention will be further described in detail below in conjunction with specific embodiments, and the given examples are only for clarifying the present invention, not for limiting the scope of the present invention. The experimental methods in the following examples are conventional methods unless otherwise specified. The materials and reagents used in the following examples can be obtained from commercial sources unless otherwise specified.

[0046]

[0047] 1. Preparation of fusion proteins SUMO-C1D, SUMO-CCL18, SUMO-CXCL1, SUMO-TM4SF1, SUMO-FXR1 and SUMO-TIZ

[0048] 1.1 Construction of prokaryotic expression vectors for C1D, CCL18, CXCL1, TM4SF1, FXR1, and TIZ

[0049] Trizol reagent was used to extract total RNA from ovarian tissue (from a patient with ovarian serous cystadenocarcinoma undergoing surgical resection in the Department of Gynecologic Oncology, Guangxi Medical University Tumor Hospital, and confirmed by pathology) with one-step method ...

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Abstract

The invention discloses a system for multi-index combined diagnosis of ovarian cancer and / or non-ovarian malignant tumors. The system for auxiliary diagnosis of the ovarian cancer and / or non-ovarian derived malignant tumors includes a system for detection of the content of six proteins in serum, wherein the six proteins comprise CCL18, CXCL1, a C1D IgG type self antibody, a TM4SF1 IgG type self antibody, an FXR1 IgG type self antibody and a TIZ IgG type self antibody; the non-ovarian malignant tumors comprise breast cancer, liver cancer or lung cancer. The system has relatively high diagnostic efficiency for ovarian cancer, breast cancer, liver cancer and lung cancer.

Description

technical field [0001] The invention relates to a multi-index combined diagnosis system for ovarian cancer and / or malignant tumors not derived from the ovary in the field of tumor diagnosis. Background technique [0002] At present, the methods of clinical ovarian cancer (ovarian malignant tumor) examination mainly include: (1) physical examination, (2) serum tumor marker detection, (3) cytological or histological case diagnosis (gold standard). The detection of tumor markers has the characteristics of reproducibility, simplicity, low cost, high sensitivity, high specificity, is closely related to tumor size or stage, and can monitor the effect of treatment, etc. CA125 (carbohydrate antigen 125) is the most widely used ovarian cancer tumor marker in clinical practice. Although it has higher sensitivity than other tumor markers, CA125 can also increase in pelvic inflammation, endometriosis, and uterine fibroids, and its specificity is low. In addition to CA125, many tumor m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N33/574
CPCG01N33/57415G01N33/57423G01N33/57438G01N33/57449G01N33/57484G01N2800/50
Inventor 李力赵冰冰王琪阳志军苏节
Owner GUANGXI MEDICAL UNIVERSITY
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