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Medicine having analgesic action

A drug and composition technology, applied in the field of drugs with analgesic effect, can solve problems such as restricted use

Active Publication Date: 2017-01-04
于龙川
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned toxic and side effects of opioid analgesics greatly limit the clinical use of such drugs

Method used

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  • Medicine having analgesic action
  • Medicine having analgesic action
  • Medicine having analgesic action

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Example 1, the analgesic effect of the composition composed of 5-azacytosine (5-Aza) and trichostatin A (TSA) in acute pain rats

[0044] 1. The analgesic effect of different doses of 5-azacytidine (5-Aza) solution injected intraperitoneally in rats

[0045] The different doses of 5-Aza solutions of equal volumes were injected intraperitoneally to normal rats, and four groups of rats ( figure 1marked as 0.1mg / kg 5-Aza, 0.5mg / kg 5-Aza, 1mg / kg 5-Aza and 2mg / kg 5-Aza respectively), the control group was injected with an equal volume of sterile normal saline ( figure 1 marked as saline), and there were 8 rats in each group. The experimental test method is the same as the operation method of the above-mentioned hot plate test and pressure plate test. The HWL value of the tested rat is tested as the basic value before the injection of the drug, and each dose is measured at the time points of 10, 30 and 60 minutes after the injection of each dose of 5-Aza solution. The paw w...

Embodiment 2

[0075] Example 2, the analgesic effect of a composition composed of 5-azacytosine (5-Aza) and trichostatin A (TSA) in neuropathic pain rats

[0076] In the experiment, a rat neuropathic pain model was made by mild ligation of the sciatic nerve, and the specific steps were referred to the method of Bennett and Xie (Bennett & Xie 1988). Rats were fully anesthetized with sodium pentobarbital (50 mg / kg body weight) in lateral recumbency with the ligated side (left side) up. Shave off the rat hair from the ligated thigh to the femur, fully expose the outer thigh skin, disinfect with iodine, and deiodine with alcohol. Cut the skin and subcutaneous tissue posteriorly along the outer contour of the femur. Extend the femoral fascia to expose the adductor muscle, and pull the adductor muscle posteriorly to expose the deep sciatic nerve. The sciatic nerve is a white thick nerve, and the surrounding connective tissue is peeled off with a glass minute needle to free the sciatic nerve. U...

Embodiment 3

[0080] Example 3, the analgesic effect of the composition composed of 5-azacytosine (5-Aza) and trichostatin A (TSA) in inflammatory pain rats

[0081] Firstly, a rat model of inflammatory pain was made. The left hind limb of the rat was fixed, and 0.1ml of newly prepared 2% carrgeenan was quickly injected into the left plantar pad of the rat to induce local inflammation, and the control group was injected with the same volume of normal saline. Local edema caused by inflammation can be observed after one hour. After the injection of the inflammatory agent, the hind feet of the rats were obviously red and swollen, and the local skin temperature increased. The rats licked the hind feet repeatedly, and showed symptoms of pain sensitivity to noxious thermal and noxious mechanical stimuli. The local inflammatory reaction can last for 8-10 hours, and it is the most serious at 3-4 hours, so the administration and pain measurement experiments were carried out 3 hours after the inject...

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Abstract

The invention discloses a medicine having an analgesic action. A composition, which consists of 5-azacytidine and trichostatin A, has a synergistic effect and shows an obvious analgesic effect; in comparison with morphine, as a representative opiate analgesic, the medicine can take a similar analgesic action; and moreover, the medicine, after being used for several times, is free from the generation of tolerance and addiction, and in addition, the motion capacity of animals is not affected. The composition, which consists of the 5-azacytidine and the trichostatin A, can achieve the analgesic effect, which is similar to that of the morphine, on various acute pains, neuropathic pains and inflammatory pains in the clinical field.

Description

technical field [0001] The invention relates to a medicine with analgesic effect in the medical field. Background technique [0002] Opioid analgesics are currently the most widely used analgesics in clinical practice, and their representative drugs are morphine, codeine (methylmorphine), pethidine (demerol), tramadol, etc. Opioid analgesics have powerful analgesic effects, but they cause many adverse reactions, such as constipation, nausea, respiratory depression, and central nervous system toxicity. In addition, after repeated use of opioid analgesics, users will develop tolerance and dependence, which will easily lead to the abuse of such drugs, so they are also called addictive analgesics. The above-mentioned toxic and side effects of opioid analgesics greatly limit the clinical use of such drugs. Therefore, it is urgent to develop analgesics without tolerance and addiction. At present, domestic and foreign research institutions and pharmaceutical companies are workin...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/706A61P29/00A61P25/04A61K31/165
Inventor 于龙川
Owner 于龙川
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