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Transmembrane polypeptide with analgesic effect

A technology of pain sensitization and sequence, applied to medical preparations containing active ingredients, peptides, desipeptides, etc.

Active Publication Date: 2015-04-29
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

But so far, no single factor can completely explain the formation mechanism of pain sensitization, but each messenger molecule in the cell interacts and restricts each other to form an intricate signal transmission network, and jointly participate in the generation of pain sensitization

Method used

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  • Transmembrane polypeptide with analgesic effect
  • Transmembrane polypeptide with analgesic effect
  • Transmembrane polypeptide with analgesic effect

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1, the functional experiment of TAT-S3

[0038] 1. Design of TAT-S3peptide

[0039]The LIMK (LIM motif-containing protein kinase, LIMK) protein kinase family is a serine protein kinase that only includes two members, LIMK1 and LIMK2. The basic structural characteristics of the two members are the same, including two consecutive LIM domains and a PDZ domain at the N-terminus, and a protein kinase domain at the C-terminus, and there is a serine / proline between the PDZ domain and the protein kinase domain Acid rich area. Since the discovery of LIMK1 and LIMK2, people's functional research in the nervous system has focused on the regulation of neuron development. It has been found that LIMK can regulate the morphology and movement of growth cones and the extension of neurites by phosphorylating cofilin, and participate in various Stimulation-induced neuron-guided outgrowth. There are many evidences suggesting that LIMK may be involved in the regulation of pain...

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Abstract

The invention discloses a transmembrane polypeptide with an analgesic effect. The transmembrane polypeptide is any polypeptide shown in (a) to (c), wherein the amino acid sequence of the polypeptide shown in (a) is shown by amino acid residues 10 to 25 of a sequence I in a sequence table; the amino acid sequence of the polypeptide shown by (b) is shown in the sequence I in a sequence table; and the polypeptide shown by c is a derived polypeptide, which is obtained by mutating the polypeptide shown by (a) or (c) in the following manner and has the at least one effect of (1) to (3), the mutation manner comprises the steps of: replacing, deleting and / or adding one to ten of the amino acid residues 10 to 25 of the sequence I in the sequence table except for the amino acid residue 12 of the sequence 1, the effect (1) is the prevention and / or treatment of pain, the effect (2) is the disturbance of phosphorylation of actin-depolymerzing protein / cofilin, and the effect (3) is reduction of the function of transient receptor potential vanillic acid subtype 1. The transmembrane polypeptide with the analgesic effect can be used for preventing and / or treating pain.

Description

technical field [0001] The invention relates to a membrane-penetrating polypeptide with analgesic effect. Background technique [0002] Pain under physiological conditions can be used as an early warning system for the body to damage the body, causing the body's defensive protective response. However, chronic pathological pain can be produced under some pathological conditions, which constitutes an unbearable torture to the body. Therefore, pain, as a disease, has become a major hazard that seriously affects people's daily work and life and quality of life. With the accelerated pace of life and the aging society, the incidence of various pain diseases, especially chronic inflammatory pain, is increasing. However, due to the complex etiology of chronic pathological pain, the molecular mechanism and pathophysiological process are not fully understood, so there is still a lack of effective and specific treatments. [0003] Regarding the pathogenesis of pain, it is currently ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07K7/08C07K14/00C12N15/11C12N15/63C12N5/10C12N1/15C12N1/19C12N1/21A61K38/10A61K38/16A61K48/00A61P29/00
Inventor 王韵李逸陈海靖胡芳杜怡娟
Owner PEKING UNIV
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