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Polypeptide for preventing and/or treating pain and application of polypeptide

A peptide and action technology, applied in gene therapy, medical preparations containing active ingredients, peptides, etc., can solve the problems of lack of treatment methods, complex etiology of chronic pathological pain, incomplete understanding of molecular mechanisms and pathophysiological processes, etc.

Inactive Publication Date: 2012-12-05
PEKING UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the complex etiology of chronic pathological pain, the molecular mechanism and pathophysiological process are not fully understood, so there is still a lack of effective and specific treatments

Method used

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  • Polypeptide for preventing and/or treating pain and application of polypeptide
  • Polypeptide for preventing and/or treating pain and application of polypeptide
  • Polypeptide for preventing and/or treating pain and application of polypeptide

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Example 1. Functional experiment of the membrane-penetrating fusion peptide TAT-T506

[0041] 1. Design of TAT-T506

[0042] Inflammatory mediators cause TRPV1 sensitization mainly through the following mechanisms: reducing the thermal activation threshold of TRPV1; increasing the number of functional TRPV1 on the cell membrane of nociceptive neurons; inhibiting desensitization of channels and increasing channel activity. In addition, long-term inflammatory stimulation can also increase the total content of TRPV1 in neurons, and then maintain a high level of functional receptors located on the cell membrane [6] . However, inflammatory mediators do not act directly on TRPV1, but activate downstream signal transduction pathways by binding to their respective receptors on the peripheral apex of nociceptive neurons, and indirectly act on and sensitize TRPV1. Among these downstream signal transduction molecules, protein kinase is a very important member. Protein kinases c...

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Abstract

The invention discloses a polypeptide for preventing and / or treating pain and an application of the polypeptide. The polypeptide is the following polypeptide in a), b) or to c): a) the polypeptide is shown in the 10th to the 24th amino acid residues in an amino acid sequence such as the first sequence in a sequence table; b) the polypeptide is shown in the amino acid sequence such as the first sequence in the sequence table; and c) the polypeptide is derived polypeptide with at least one effect in 1) to 3) and is obtained by mutating the polypeptide in the a) or the b) by the following way: carrying out substitution, deletion and / or addition of 1-10 amino acid residues on the amino acid residues except for the 17th, the 18th and the 20th amino acid residues in the amino acid residues of the first sequence in the sequence table, wherein the 1) to the 3) are as follows: 1) prevention and / or treatment of pain, 2) reduction of the content of a vanillic subtype 1 of a transient receptor potential on a neuronal cell membrane, and 3) inhibition of a membrane transport function of the vanillic subtype 1 of the transient receptor potential. The polypeptide can be used for preventing and / or treating pain.

Description

technical field [0001] The present invention relates to a polypeptide for preventing and / or treating pain and its application. Background technique [0002] Under normal conditions, physiological pain caused by noxious stimuli acting on the body can be used as a warning, causing the body to produce a series of protective responses to avoid or reduce damage. However, under pathological conditions such as inflammation and nerve damage, the efficiency of pain transmission may be enhanced for a long time, which in turn triggers hyperalgesia (hypersensitivity), and the clinical manifestation is long-term severe chronic pain. [1] . Chronic pathological pain is one of the most common clinical symptoms. In addition to causing strong discomfort to the body, it will also have an adverse impact on the mental and psychological effects of the affected population, and it has been regarded as a disease that seriously affects people's daily work and life. and quality of life in neuropsych...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K7/08C07K14/00C12N15/11C12N15/63C12N5/10C12N1/15C12N1/19C12N1/21A61K38/10A61K38/16A61K48/00A61P29/00
Inventor 王韵杨艳蕊邢宝明杜军霞张瑛
Owner PEKING UNIV
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