The present invention relates to a method for preventing or treating
cancer and its use therefor. The method or use may include administering a
cancer therapy together with a compound of Formula (I). In the compound of Formula (I), A is a substituted heteroaryl containing at least one ring
nitrogen, and D includes optionally substituted phenyl, N-linked 3,4-dihydro-2H-benzo[b][1,4]oxazinyl, N-linked 10H-phenoxazinyl, indole, pyridinyl, pyrimidinyl, pyrazolo[1,5-a]pyridinyl, or thienyl (or R3' and D together form a 5- or 6-membered ring). The compound of Formula (I) may be an inhibitor of transient
receptor potential vanilloid 6 (TRPV6). The
cancer therapy may be a chemotherapeutic agent. The present invention also relates to pharmaceutical compositions and kits containing the compound of Formula (I) and / or a chemotherapeutic agent. TIFF2026502807000127.tif30170