Target functional material based on oxygen free radicals and application of target functional material

A functional material, free radical technology, applied in the field of medicine, can solve problems such as protein denaturation, cell and tissue damage, and accelerated body aging.

Inactive Publication Date: 2017-01-04
EAST CHINA UNIV OF SCI & TECH
View PDF6 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, if there are too many free radicals in the body, it can cause protein (protein food) and nucleic acid (DNA) denaturation, cause damage to cells, tissues and organs, induce various diseases, and accelerate the aging of the body

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Target functional material based on oxygen free radicals and application of target functional material
  • Target functional material based on oxygen free radicals and application of target functional material
  • Target functional material based on oxygen free radicals and application of target functional material

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0058] Validation of TEMPO's targeting of tumor sites (1):

[0059] 1. Synthesis of basic copolymer PLA-PNNUA-PNAS

[0060] In the first step, a certain proportion of N-isopropylmethacrylamide, N-isopropylmaleamic acid, and 10-undecylenic acid is added to the flask, and dissolved in DMF (dimethylformamide). Add AIBN (azobisisobutyronitrile) and polylactic acid macromolecular RAFT initiator. Nitrogen deoxygenation. React at 80°C for 6 hours. After the reaction was completed, the reaction solution was poured into anhydrous ether, and the obtained precipitate was collected by centrifugation, washed and dried under vacuum at room temperature to obtain white powder PLA-PNNUA.

[0061] In the second step, the basic copolymer PLA-PNNUA-PNAS was prepared with PLA-PNNUA as the RAFT initiator and monomer NAS (N-methacryloyloxysuccinimide). Add PLA-PNNUA and NAS monomers to the flask, add 5mL DMF to dissolve, and add AIBN. Nitrogen deoxygenation. React at 80°C for 6 hours. After t...

Embodiment 2

[0102] Validation of TEMPO's targeting of tumor sites (2):

[0103] Preparation of TEMPO micelles embedding hydrophobic quantum dots, using the example 1 scheme to verify the targeting of TEMPO—preparation of CdTe quantum dots (QDs)

[0104] 1 Preparation of water-soluble CdTe quantum dots

[0105] CdCl2·2.5H 2 O (0.04mol / L, 4mL) was added into a 100mL three-necked flask and diluted to 50mL. Under magnetic stirring, add 100mg sodium citrate successively, Na 2 TeO 3 (0.01mol / L, 4mL), 50mg MPA, 50mg NaBH 4 . When the color of the solution turns gray-green, it is placed in an oil bath and heated to reflux at 100° C., and the CdTe quantum dots are obtained by controlling the reaction time for 1-12 hours.

[0106] 2 Preparation of oil-soluble CdTe QOs

[0107] Take 2mM water-soluble CdTe QDs, add 5ml of dodecanethiol and 20ml of acetone, connect to the reflux device, heat in a water bath at 70°C, and react with magnetic stirring for 3h, remove the acetone by rotary evaporati...

Embodiment 3

[0119] Targeted verification of TEMPO on inflammation:

[0120] Using Periplaneta americana extract, cockroach extract and other methods to induce pneumonia model in mice, using the materials and test methods in Example 1 to verify the targeting of TEMPO to inflammation, the results show that the drug-loaded carrier containing TEMPO has an effect on the inflammation site Certain targeting.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to a target functional material based on oxygen free radicals. The target functional material is characterized in that the target functional material is a ligand having a tumor target function and has a target function. The target functional material is used as a target material for treating a tumor site, a target material for treating an inflammatory site, a target material for treating arteriosclerosis or a target material for treating gastritis, a target material for treating peptic ulcer, a material for treating brain reperfusion injury or gastritis, a material for treating peptic ulcer, a material for treating primary glomerulopathy or diabetes, a material for treating bronchial asthma, and a material for treating pulmonary emphysema or a material for treating paralysis agitans. The invention provides a novel ligand having a tumor target function, and the target functional material is sensitive to oxygen free radicals, can conveniently perform tracking and monitoring by virtue of EPR, is low in price and easy to store, can be connected with various nano carriers, and can simultaneously realize the target administration and tumor detection.

Description

[0001] 【Technical field】 [0002] The invention relates to the technical field of medicines, in particular to a targeted functional material based on the principle of oxygen free radicals and its application. [0003] 【Background technique】 [0004] Cancer is still one of the most serious diseases in the world, with 10 million new cases every year. According to statistics, the incidence rate of malignant tumors in my country is 235.23 / 100,000 (268.65 / 100,000 for men and 200.21 / 100,000 for women), and the standardized rate (standardized rate) of the Chinese population is 184.58 / 100,000. The national malignant tumor mortality rate was 148.81 / 100,000 (male 186.37 / 100,000, female 109.42 / 100,000). Although there are many anti-tumor drugs today, most of them are not selectively distributed in the body or have poor water solubility. How to diagnose and treat tumors in a targeted manner is very important. In recent years, with the rapid development of nanotechnology, it has brought g...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K47/48A61P35/00A61P29/00A61P9/10A61P1/00A61P1/04A61P7/02A61P13/12A61P3/10A61P11/06A61P11/00A61P25/16
Inventor 赵红莉陶亮蓝闽波袁慧慧刘心梦贡文秀
Owner EAST CHINA UNIV OF SCI & TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap