A kind of co-extruded film for peritoneal dialysis fluid bag and preparation method thereof

Abstract

The invention discloses a co-extruded film for aperitoneal dialysis solution bag and a method for preparing the same. The co-extruded film for theperitoneal dialysis solution bag comprises a heat sealing layer A, an inner bonding layer B, a structural layer C, an outer bonding layer D and an outer layer E which are sequentially arranged from inside to outside; the material of the heat sealing layer A is mixed resin consisting of modified polypropylene (PP) and ethylene-octene copolymer (POE),the material of the inner bonding layer B is ethylene-vinyl acetate (EVA),the material of the structural layer C is polyethylene (PE), the material of the outer bonding layer D is mixed resin consisting of ethylene-vinyl acetate copolymer (EVA) and ethylene-methyl acrylate copolymer (EMA), and the material of the outer layer E is modified polypropylene (PP). The co-extruded film for theperitoneal dialysis solution bag provided by the invention has excellent comprehensive performance and the manufacturing cost is low.

Description

technical field [0001] The invention relates to the field of new materials for medical packaging, in particular to a co-extrusion film for a peritoneal dialysis fluid bag and a preparation method thereof. Background technique [0002] Peritoneal dialysis solution was originally packaged in a single bag, and later the "O-set" system and "double-packed double-bag" system gradually appeared. The continuous improvement of packaging has brought about a significant decrease in the incidence of peritonitis and significantly improved the survival rate of peritoneal dialysis patients. The number of peritoneal dialysis patients is also increasing year by year. For more than ten years, the "double-pack double-bag" peritoneal dialysis solution has become the first choice for clinical peritoneal dialysis solution packaging system because of its advantages of easy operation by medical staff and patients, safe and reliable performance, and beneficial to reduce the risk of infection. [00...

AI Technical Summary

Problems solved by technology

The main problems of polyvinyl chloride (PVC) film are: (1) in the production process of polyvinyl chloride (PVC) film, diethylhexyl phthalate (DEHP) plasticizer is added in order to change its performance. Diethylhexyl phthalate (DEHP) plasticizer may dissolve during use. Diethylhexyl phthalate (DEHP) is a harmful substance and can release estrogen. Exposure to phthalic acid Diethylhexyl ester (DEHP) may lead to dysplasia of the reproductive system and seriously endanger human health; (2) Polyvinyl chloride (PVC) raw materials are usually added with calcium, zinc, barium and other elements in order to prevent resin degradation in the production process These metal ions may migrate during the use of the dialysate, and enter the human body with the liquid medicine or blood, which will affect human health; (3) Polyvinyl chloride (PVC) film has poor heat resistance, 121 ° C After high-temperature sterilization, the membrane material is seriously bleached, and the light transmittance is low. It is difficult for medical staff to distinguish whether the liquid medicine has deteriorated through the appearance, which can easily lead to medical accidents.

(4) It has strong adsorption to some fat-soluble and alcohol-soluble drugs, which leads to inaccurate prescription dosage and reduced curative effect; (5) The permeability of polyvinyl chloride (PVC) film to oxygen and water vapor is extremely large, The barrier property is very poor, so the validity period of the packaged medicine is only 1 year; (6) Polyvinyl chloride (PVC) and its copolymers will form hydrochloric acid after burning, causing respiratory damage to humans and animals and erosion of buildings. Prone to produce dioxins and have far-reaching impacts on the environment

[0004] The main problems of non-PVC co-extrusion infusion membrane are: (1) The flexibility of the material is not good. Small range, not resistant to 135°C high-temperature steam sterilization, poor low-temperature impact resistance, especially the probability of damage and leakage of large-scale dialysis bags during low-temperature transportation is greatly increased; (3) The single welding heat sealing method can only be used High temperature hot pressing

(4) The inner layer is not easy to peel, it is difficult to make "O-set" system and "double double bag"

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