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Medicine compound for increasing safety of compound codonopsis pilosula injection

A technology of composition and injection, applied in the field of medicine, can solve problems such as polysorbate 80 is prone to rancidity, the pH value of the solution drops, and accelerates the pH value of the liquid medicine, etc., and achieves the effect of improving safety, high dosage, and good safety

Inactive Publication Date: 2017-01-11
CHENGDU XIANXIANXIAN BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, the traditional Chinese medicine injection itself still has the problem that the pH value of the solution drops significantly during the sterilization and storage process, and polysorbate 80 (Tween 80) is prone to rancidity, which accelerates the drop of the pH value of the liquid medicine.

Method used

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  • Medicine compound for increasing safety of compound codonopsis pilosula injection
  • Medicine compound for increasing safety of compound codonopsis pilosula injection
  • Medicine compound for increasing safety of compound codonopsis pilosula injection

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026]

[0027] Preparation method: Codonopsis pilosula and Xiaxia are decocted twice without adding water, 2 hours each time, combined with decoction, filtered, the filtrate is concentrated under reduced pressure to a relative density of 1.27-1.30 (80 ° C), let it cool, add ethanol to make the ethanol content It was 65%, left standing overnight, filtered, the filtrate was decompressed to recover ethanol and concentrated to a relative density of 1.30 (80 ° C), 3 times the amount of water was added, fully stirred, refrigerated for 48 hours, filtered, and the filtrate was concentrated under reduced pressure to a relative density of 65%. The density is about 1.15 (80°C), the medicinal liquid is for use; the horse chestnut is boiled twice with water for 1 hour each time, the decoction is combined, filtered, and the filtrate is concentrated to a relative density of 1.25 to 1.30 (80°C), let cool , add ethanol to make the ethanol content be 65%, let stand overnight, filter, concent...

Embodiment 2

[0029]

[0030] Preparation method: Codonopsis pilosula and Xiaxia are decocted twice without adding water, 2 hours each time, combined with decoction, filtered, the filtrate is concentrated under reduced pressure to a relative density of 1.27-1.30 (80 ° C), let it cool, add ethanol to make the ethanol content It was 65%, left standing overnight, filtered, the filtrate was decompressed to recover ethanol and concentrated to a relative density of 1.30 (80 ° C), 3 times the amount of water was added, fully stirred, refrigerated for 48 hours, filtered, and the filtrate was concentrated under reduced pressure to a relative density of 65%. The density is about 1.15 (80°C), the medicinal liquid is for use; the horse chestnut is boiled twice with water for 1 hour each time, the decoction is combined, filtered, and the filtrate is concentrated to a relative density of 1.25 to 1.30 (80°C), let cool , add ethanol to make the ethanol content be 65%, let stand overnight, filter, concent...

Embodiment 3

[0032]

[0033]Preparation method: Codonopsis pilosula and Xiaxia are decocted twice without adding water, 2 hours each time, combined with decoction, filtered, the filtrate is concentrated under reduced pressure to a relative density of 1.27-1.30 (80 ° C), let it cool, add ethanol to make the ethanol content It was 65%, left standing overnight, filtered, the filtrate was decompressed to recover ethanol and concentrated to a relative density of 1.30 (80 ° C), 3 times the amount of water was added, fully stirred, refrigerated for 48 hours, filtered, and the filtrate was concentrated under reduced pressure to a relative density of 65%. The density is about 1.15 (80°C), the medicinal liquid is for use; the horse chestnut is boiled twice with water for 1 hour each time, the decoction is combined, filtered, and the filtrate is concentrated to a relative density of 1.25 to 1.30 (80°C), let cool , add ethanol to make the ethanol content be 65%, let stand overnight, filter, concentr...

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Abstract

The invention discloses a medicine compound for increasing the safety of a compound codonopsis pilosula injection. The medicine compound is an injection medicine compound which is made from codonopsis pilosula extract, corydalis amabilis extract, schefflera arboricola extract and tert-butyl peroxyacetate. According to the invention, a cosolvent with higher safety and more obvious fluxing effect is used for replacing the cosolvent polysorbate 80 with potential safety hazards and influences on product quality in the compound codonopsis pilosula injection, the safety of tert-butyl peroxyacetate is higher than the safety of polysorbate 80 and the dosage is less, so that the probability and risk of untoward effects of the medicine can be reduced and the safety of clinical medication can be increased.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a pharmaceutical composition for improving the safety of compound Codonopsis injection. Background technique [0002] The standard of compound Codonopsis injection is contained in the drug standard issued by the Ministry of Health (preparation of traditional Chinese medicine). It has the effect of promoting blood circulation, removing blood stasis and relieving pain. Clinically used for the treatment of dysmenorrhea, amenorrhea, fall injury, rheumatic arthralgia and so on. [0003] Compound Codonopsis injection has been widely used in clinic for many years in my country, and its clinical efficacy has been well received by both doctors and patients. However, in recent years, reports of adverse reactions in the clinical application of traditional Chinese medicine injections have become increasingly serious, affecting the development of traditional Chinese medicine in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/66A61K47/14A61K9/19A61K9/08A61P15/00A61P29/00
CPCA61K36/344A61K9/0019A61K9/08A61K9/19A61K36/25A61K36/66A61K47/14A61K2300/00
Inventor 付裕
Owner CHENGDU XIANXIANXIAN BIOTECH CO LTD
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