Bispyrene-based pH (Potential of Hydrogen)-response self-assembly polypeptide nano material, and preparation method and application thereof

A nanomaterial and self-assembly technology, applied in the field of nanomaterials, can solve problems such as limiting biological applications, achieve wide application prospects, improve utilization rate, and achieve good stability
CN106349331AActive Publication Date: 2017-01-25THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
Publication Date
2017-01-25

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Abstract

The invention provides a bispyrene-based pH (Potential of Hydrogen)-response self-assembly polypeptide nano material, and a preparation method and application thereof. The bispyrene-based pH-response self-assembly polypeptide nano material has a structure as shown in formulas I to IV. The bispyrene-based pH-response self-assembly polypeptide nano material has pH response, can be self-assembled into nano fiber under the environment that the pH is greater than or equal to 1.0 and smaller than 8.0 and can be assembled into nanospheres under the environment that the pH is greater than or equal to 8.0, and a hydrophobic micromolecular imaging agent and medicine can be recruited, so that the utilization rate of the micromolecular imaging agent and treatment medicine can be greatly increased; the bispyrene-based pH-response self-assembly polypeptide nano material can be converted into fiber in positions of ill tissues or cells in situ, is capable of greatly prolonging the retention time, can be used for biological imaging and treating, is capable of providing a reliable diagnosis and targeted therapy method for disease treatment, and has a wide application prospect.
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Description

technical field

[0001] The invention belongs to the technical field of nanomaterials and relates to a polypeptide nanomaterial and its preparation method and application, in particular to a bipyrene-based pH-responsive self-assembled polypeptide nanomaterial and its preparation method and application. Background technique

[0002] In recent years, the application of nanomaterials in the diagnosis and treatment of clinical diseases has received great attention. Peptide self-assembled nanomaterials are widely used in bioimaging and therapy due to their good biocompatibility and chemical diversity. Nanomaterials with different sizes and shapes have great impact on biological imaging and therapy. For example, nanoparticles, related studies have shown that when the size of nanoparticles is 10-100nm, the circulation time of nanoparticles in the body will be increased; and when the size of nanoparticles is 15-350nm, nanoparticles will be targeted and aggregated to myocardial infar...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
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