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Solid dispersion for treating peptic ulcer

A solid dispersion and peptic ulcer technology, applied in the digestive system, medical preparations containing active ingredients, plant/algae/fungus/moss components, etc., can solve the problems of many medicinal tastes, high cost, and large dosage of medicinal materials. To achieve the effect of improved anti-ulcer activity, less side effects, and ideal pain relief effect

Inactive Publication Date: 2017-02-15
门源县雪草木生物药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above-mentioned prescriptions have more medicinal flavors, a larger amount of medicinal materials, and higher costs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1 Preparation of the pharmaceutical composition of the present invention

[0022] Zushima 2g, Atractylodes macrocephala 10g, Ganoderma lucidum 3g, Codonopsis 8g, Pseudostellaria 8g, capillary 8g, dandelion 10g, bellflower 5g, patchouli 5g, nutmeg 4g; after drying, crush to 250 mesh and mix well to get Raw drug powder.

[0023] Take raw drug powder: polyethylene glycol-6000=1:3w / w, mix well, heat until polyethylene glycol-6000 is in a molten state, stir, immediately place in 0°C environment and quench until solidified, crush to obtain Solid dispersion.

Embodiment 2

[0024] Embodiment 2 Preparation of the pharmaceutical composition of the present invention

[0025] Zushima 2g, Atractylodes macrocephala 10g, Ganoderma lucidum 3g, Codonopsis 8g, Pseudostellaria 8g, Capillary 8g, Dandelion 10g, Bellflower 5g, Patchouli 5g, Nutmeg 4g; after drying, crush to 300 mesh, mix evenly to get Raw drug powder.

[0026] Take the raw drug powder: polyethylene glycol-6000=1:5w / w, mix well, heat until the polyethylene glycol-6000 is in a molten state, stir, immediately place it in an environment of 0°C and quench until it solidifies, crush it to obtain Solid dispersion.

[0027] Embodiment 1 Preparation of the pharmaceutical composition of the present invention

[0028] Zushima 2g, Atractylodes macrocephala 10g, Ganoderma lucidum 3g, Codonopsis 8g, Pseudostellaria 8g, capillary 8g, dandelion 10g, bellflower 5g, patchouli 5g, nutmeg 4g. Add water to decoct 3 times, the first time add 10 times the amount of water and decoct for 5 minutes, the second time ...

Embodiment 3

[0031] Embodiment 3 Preparation of the pharmaceutical composition of the present invention

[0032] Zushima 2g, Atractylodes macrocephala 10g, Ganoderma lucidum 3g, Codonopsis 8g, Pseudostellaria 8g, capillary 8g, dandelion 10g, bellflower 5g, patchouli 5g, nutmeg 4g. First add 4 times the amount of water to soak for 10 minutes, then add water to decoct for 2 times, each time for 20 minutes, add 10 times the amount of water each time, filter, and combine the decoctions to obtain the pharmaceutical composition decoction of the present invention.

[0033] Typical case 1

[0034] Li, male, 26 years old, had epigastric discomfort after eating, accompanied by belching, pantothenic acid, and occasional vomiting, and the symptoms had lasted for 2 months. After diagnosis, it was confirmed as chronic superficial gastritis.

[0035] After taking the decoction of the Chinese medicine compound of Example 1 for 5 days, epigastric discomfort and belching symptoms were relieved. After 20 d...

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Abstract

The invention provides a solid dispersion for treating peptic ulcer. The solid dispersion is prepared from the active pharmaceutical ingredient powder and polyethylene glycol-6000 in a weight ratio of (1-2) to (3-5); and the active pharmaceutical ingredient powder is prepared by grinding the following active pharmaceutical ingredients in parts by weight into 200-500 meshes: 1-3 parts of daphne giraldii nitsche, 7-13 parts of rhizoma atractylodis macrocephalae, 2-3 parts of lucid ganoderma, 5-10 parts of codonopsis pilosula, 5-10 parts of radix pseudostellariae, 5-10 parts of capillary artemisia, 5-10 parts of dandelions, 3-7 parts of platycodon grandiflorum, 3-7 parts of pogostemon cablin and 2-4 parts of nutmeg. According to the solid dispersion, the active pharmaceutical ingredient powder is prepared into the solid dispersion, the bioavailability of the medicines is improved, and the anti-ulcer activity is obviously improved.

Description

technical field [0001] The invention relates to a solid dispersion for treating peptic ulcer. Background technique [0002] Gastric and duodenal ulcers refer to localized round or oval full-thickness defects of gastric and duodenal mucosa, the muscularis mucosae is penetrated, and fibrous scars inevitably remain after healing, with a layer of epithelium on the surface Overlying, the muscularis mucosa cannot regenerate. The etiology can be summed up as the self-digestion of gastric mucosa by gastric acid and pepsin or the destruction of gastric mucosal barrier due to various reasons. In recent years, it has been considered that the formation of ulcers has an important relationship with Helicobacter pylori infection in the stomach. [0003] Chronic superficial gastritis is a disease of chronic superficial inflammation of the gastric mucosa. It is a common disease of the digestive system and belongs to chronic gastritis. It can be caused by alcoholism, strong coffee, bile re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/83A61K9/14A61K47/10A61P1/04
CPCA61K36/83A61K9/146A61K36/074A61K36/185A61K36/282A61K36/284A61K36/288A61K36/344A61K36/346A61K36/36A61K36/53A61K2300/00
Inventor 徐继锋许婧
Owner 门源县雪草木生物药业有限公司
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