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Application of a kind of total alkaloids of Dendrobium nobile

A technology of Dendrobium nobile and biological total alkaloids, applied in the field of medicine, to achieve the effects of reducing MDA content, intact liver lobules, and reducing inflammatory cell infiltration

Active Publication Date: 2021-07-02
ZUNYI MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the prior art, there is no relevant report on the use of total alkaloids of Dendrobium nobile in the preparation of drugs for the prevention or treatment of acute and chronic liver damage

Method used

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  • Application of a kind of total alkaloids of Dendrobium nobile
  • Application of a kind of total alkaloids of Dendrobium nobile
  • Application of a kind of total alkaloids of Dendrobium nobile

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0137] Application of total alkaloids of dendrobium nobile in the preparation of medicines for preventing or treating acute and chronic liver injury diseases. The medicine is a tablet made by adding total alkaloids of Dendrobium nobile as active ingredients and adding pharmaceutical carriers or excipients. The tablet is prepared through the following steps: use wet granulation to compress the tablet, and mix 1 part of total alkaloids dry powder of Dendrobium nobile and 3 parts of starch according to parts by weight, and add starch slurry with a mass fraction of 10% to make a soft material , the starch slurry contains citric acid with a mass fraction of 1%, making it lightly gripped into agglomerates, lightly pressed to disperse, passing through a 16-mesh sieve to granulate, drying the wet granules at 40°C to 60°C, and sizing through a 16-mesh sieve granules, and adding 5% talcum powder of the mass of the prepared granules, mixing evenly, and directly compressing into tablets. ...

Embodiment 2

[0139] Application of total alkaloids of dendrobium nobile in the preparation of medicines for preventing or treating acute and chronic liver injury diseases. The medicine is a capsule prepared by adding the total alkaloids of Dendrobium nobile as active ingredients and adding pharmaceutical carriers or excipients. The capsules are prepared by the following steps: mixing the dry powder of total alkaloids of Dendrobium nobile and soluble starch whose mass is 5 times that of the dry powder, passing through a 100-mesh sieve, and manually filling into No. 5 capsules. The total alkaloids of Dendrobium nobile are prepared through the following steps: take the medicinal material of Dendrobium nobile and grind it into a coarse powder, extract 3 times at room temperature with 95% ethanol whose mass is 12 times the mass of the coarse powder, each time for 15 days, and combine the extracts After filtration, ethanol is reclaimed under reduced pressure, evaporated until the extract has no ...

Embodiment 3

[0141] Application of total alkaloids of dendrobium nobile in the preparation of medicines for preventing or treating acute and chronic liver injury diseases. The drug is a granule prepared by adding the total alkaloids of Dendrobium nobile as active ingredients and adding pharmaceutical carriers or excipients. The granules are prepared through the following steps: according to parts by weight, take 1 part of Dendrobium nobile total alkaloid dry powder, 3 parts of sucrose powder and 1.25 parts of dextrin and mix evenly, add 60% ethanol soft material, make it lightly hold into a Agglomerates, lightly pressed to disperse, granulated through a 16-mesh sieve, dried at 60°C-80°C, granulated with a 16-mesh sieve, and sealed. Wherein, the total alkaloids of Dendrobium nobile are prepared by the following steps: take the medicinal material of Dendrobium nobile and pulverize it into a coarse powder, extract four times at room temperature with 95% ethanol whose mass is 10 times that of ...

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Abstract

The invention discloses the application of total biological alkaloids of Dendrobium nobile in the preparation of medicines for preventing or treating acute and chronic liver damage diseases. Dendrobium nobile total alkaloids on CCL 4 , alcohol or D-galactose-induced acute liver injury, CCL 4 The resulting chronic liver injury has preventive effect. The total alkaloids of Dendrobium nobile can significantly reduce the activity of ALT and AST in serum, significantly reduce the content of MDA in liver homogenate, and increase the expression of Nrf2, Nqo1 and Ho‑1 mRNA. According to the observation of liver tissue slices, after the use of total alkaloids from Dendrobium nobile, the focal necrosis of liver tissue disappeared, the structure of liver lobules was basically intact, and the infiltration of inflammatory cells was significantly reduced.

Description

technical field [0001] The invention relates to the application of total biological alkaloids of Dendrobium nobile, and specifically belongs to the technical field of medicine. Background technique [0002] Liver disease is a type of disease that seriously endangers human health, with a high incidence rate, including viral hepatitis, liver cirrhosis, fatty liver, alcoholic liver, drug-induced liver disease, genetic liver disease, etc. liver injury, especially acute liver injury. At present, there is no uniform definition of acute liver injury. In a broad sense, abnormal liver function indicators due to any cause are indicative of liver injury (acute liver injury may be considered if ALT and AST are higher than normal limits, as recommended by the National Clinical Association of the United States). The common causes of acute liver injury are: 1. Infection: various types of hepatitis viruses are common, followed by non-hepatitis viruses; 2. Drug poisoning: acetaminophen, car...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/8984A61P1/16
CPCA61K36/8984A61K2236/333A61K2236/39A61K2236/55
Inventor 石京山吴芹陆远富周少玉张锋鲁艳柳
Owner ZUNYI MEDICAL UNIVERSITY
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