A kind of production method of ethyl vanillin glucoside

Abstract

The application discloses a production method of ethyl vanillin glucoside. The production method comprises the following production steps: (1) adding a solvent in a reaction vessel while performing stirring; (2) adding acetobromo-alpha-D-glucose and ethyl vanillin; (3) raising the temperature and adding a basic catalyst; (4) continuously carrying out the heating reaction; (5) performing filtration to remove the basic catalyst after the reaction is over; (6) recycling the moderate-polarity organic matter solvent; (7) performing reflux with toluene and a sodium hydroxide aqueous solution; (8) performing standing for layering to form an upper layer of a toluene solution and a lower layer of an aqueous phase containing impurities; (9) distilling the toluene solution, adding alcohol into the distilled residues, and performing filtering and washing to obtain ethyl vanillin tetra-acetyl glucoside; (10) adding methanol to the ethyl vanillin tetra-acetyl glucoside; and (11) performing filtering and drying to obtain white solid powder. The production method of ethyl vanillin glucoside is simple to operate, easy for industrial production, and high in yield.

Description

technical field [0001] The present invention relates to the preparation of a kind of glycoside (such as glycoside), in particular to a kind of production method of ethyl vanillin glucoside. Background technique [0002] The application of ethyl vanillin glucoside in cigarettes and baked foods can effectively improve the thermal stability of spices. At present, there are two main types of external-flavored cigarettes on the market: rose-flavored and biscuit-flavored, and the biscuit-flavored type has added ethyl vanillin. Ethyl vanillin is highly volatile, one is easy to be volatile and lost, and the other is easy to enter the mainstream smoke and cover up the natural tobacco aroma. Dube etc. cleverly utilized this property when making external-flavored cigarettes, reacted with glucose pentaacetate and HBr to obtain a-bromoglucose acetate, and this glucose tetraacetate was then reacted with ethyl vanillin React under weak base, and then deacetylate to obtain ethyl vanillin ...

AI Technical Summary

Problems solved by technology

[0006] Disadvantages: The reaction conditions are harsh, and strict anhydrous and light protection are required; the catalyst is more expensive, and the reaction steps are longer; heavy metal pollution, environmental protection pressure is high

[0009] Disadvantages: Haloglycosides are prone to elimination reactions; in most cases, the amount of the donor or acceptor in the reaction needs to be more than doubled, and the cost increases; the amount of catalyst is large, and it is not easy to recover; this method is not suitable for alkali-sensitive donors or acceptors. body glycosylation reaction

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