Application of 9bp sequence gene polymorphism in mitochondrial genome in evaluating the risk of benzene poisoning

A technology for mitochondrial and benzene poisoning, applied in the field of biomedicine, can solve unseen problems

Active Publication Date: 2019-10-25
SHENZHEN PREVENTION & TREATMENT CENT FOR OCCUPATIONAL DISEASES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The deletion type is related to the occurrence of various genetic diseases, but there is no report related to the occurrence of benzene poisoning

Method used

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  • Application of 9bp sequence gene polymorphism in mitochondrial genome in evaluating the risk of benzene poisoning
  • Application of 9bp sequence gene polymorphism in mitochondrial genome in evaluating the risk of benzene poisoning
  • Application of 9bp sequence gene polymorphism in mitochondrial genome in evaluating the risk of benzene poisoning

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1、2

[0049] Example 1, the application of the deletion type of 2 tandem repeated 9bp sequences in evaluating the risk of chronic benzene poisoning

[0050] 1. Case selection

[0051] 27 patients (6 males, average age 39.8±9.6 years old; 21 females, average age 40.7±5.9 years old) diagnosed with chronic benzene poisoning were studied and numbered p1-p27 in sequence. Forty normal healthy subjects were used as controls (24 males, with an average age of 42.1±8.3 years; 16 females, with an average age of 35.3±11.3 years), and they were numbered h1-h40 in sequence.

[0052] The above 27 patients with chronic benzene poisoning were taken as the case group, and all 27 patients with chronic benzene poisoning met the inclusion criteria of the case group. Case group inclusion criteria: Occupational chronic benzene poisoning has been diagnosed (GBZ68-2013 "Diagnostic Criteria for Occupational Benzene Poisoning").

[0053] The above 40 normal healthy subjects were taken as the control group, ...

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Abstract

The invention discloses application of the gene polymorphism of 9bp sequences of a mitochondrial genome in the evaluation of the benzene poisoning risk and application of a substance with ''two tandem-repeat 9bp sequences'' or ''two deleted tandem-repeat 9bp sequences'' in the preparation of products for evaluating the chronic benzene poisoning risk. The ''two tandem-repeat 9bp sequences'' are shown in a sequence 1 of a sequence table; and the ''two deleted tandem-repeat 9bp sequences'' are that the first to ninth nucleotides in the ''two tandem-repeat 9bp sequences'' are deleted. Experiments prove that the chronic benzene poisoning risk of an individual with the mitochondrial genome including the ''two deleted tandem-repeat 9bp sequences'' is higher than that of an individual with the mitochondrial genome including the ''two tandem-repeat 9bp sequences''. The ''two deleted tandem-repeat 9bp sequences'' can be used for evaluating the chronic benzene poisoning risk.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to the application of the 9bp sequence gene polymorphism of mitochondrial genome in evaluating the risk of benzene poisoning. Background technique [0002] In recent years, the reports of poisoning cases of benzene and benzene series have been increasing year by year, and the death cases of leukemia caused by benzene poisoning have also been increasing year by year, and the harm is very serious. Studies have shown that benzene poisoning is mainly caused by intermediate active metabolites acting on mitochondria through oxidative damage. The occurrence of chronic benzene poisoning is not only related to the exposure concentration of benzene, but also related to the genetic susceptibility of the contacts. [0003] The small non-coding sequence between the mitochondrial cytochrome C oxidase subunit II gene (abbreviated as MTCO2 gene) and the mitochondrial tRNA lysine gene (abbreviated as MTT...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12Q1/6883C12N15/11
CPCC12Q1/6883C12Q2600/156
Inventor 王佃鹏杨祥丽林大枫李培茂张志敏张艳芳黄先青
Owner SHENZHEN PREVENTION & TREATMENT CENT FOR OCCUPATIONAL DISEASES
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