Systems and methods for electronic biological sample analysis

Abstract

A biological sample analysis device comprising a housing enclosing a biological sample delivery system hydraulically connected to a sensor, wherein the sensor includes a plurality of graphene transistors and each transistor is covalently bound to a biomarker such that when the biomarker is exposed to an infected biological sample The electrical properties of the transistor were measurably altered when the corresponding antibodies were used.

Description

technical field [0001] The present disclosure relates to electronic biological sample analysis. Background technique [0002] Diagnostic techniques that involve the detection of viral or bacterial infections, or other diseases, within biological samples generally do not have the sensitivity to directly detect the presence of infectious agents such as bacteria, viruses, or diseased tissue (eg, cancer) before an immune response occurs. Thus, most diagnostic techniques detect such infections or diseases by detecting antibodies produced by the patient's immune system in response to a particular condition. For example, these antibody detection technologies are currently unable to detect many diseases (such as Lyme disease) within the first month of infection. Laboratory-scale analytical and sample processing techniques exist that can detect markers early in infection. However, these laboratory techniques require time, expertise, and materials that preclude general clinical appl...

AI Technical Summary

Problems solved by technology

This is a highly sensitive technique, but also requires a great deal of expertise or very expensive automation to run properly, and can take hours per experiment

[0008] All of these currently available tests are expensive, highly operator dependent, and lack the sensitivity and specificity to accurately and reliably detect many diseases - especially in the early stages of the disease (e.g. Lyme disease)

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