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Drug administration preparation system for nano-antibody through inner and outer cuticulae of head and neck as well as preparation method and application of drug administration preparation system

A nano-antibody, head and neck technology, applied in the field of medicine, to achieve the effect of broad application prospects, high skin application comfort, and large drug loading capacity

Inactive Publication Date: 2017-03-15
NANOLATTIX BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0028] The nanobody drug delivery system through the inner and outer skin of the head and neck is administered through the outer layer of the head and neck and the inner surface of the nasal mucosa, which has the advantages of high curative effect, convenient administration, non-invasiveness, and painless. The product preparation process is simple and suitable for industrialization Production, there is no relevant report at home and abroad

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0059] The purpose of this embodiment is to provide a nanobody drug delivery system through the inner and outer epidermis of the head and neck with water-soluble polymer protein materials as the main matrix, the preparation method of the drug delivery system, and the application of the drug delivery system .

[0060] The drug delivery system is a trans-head and neck skin and nasal mucosal drug delivery system using water-soluble polymer biocarbohydrate as the main antibody drug carrier. In the drug delivery system, a typical antibody drug carrier has an array of parts by weight. :8 parts of water-soluble polymer biocarbohydrate matrix, 8 parts of collagen, 10 parts of collagen peptides, 10 parts of polyols, 5 parts of polyvinyl alcohol, 10 parts of levolucan, 10 parts of polyamino acids, 10 parts of glycerol, 5 parts of phospholipids Parts, 2.5 parts of gelatin, 1 part of sodium carboxymethyl cellulose, 20 parts of water.

[0061] For different Nanobodies, the aforementioned antib...

Embodiment 2

[0066] In this embodiment, collagen is used as the antibody drug carrier to prepare the relevant preparations of the nano antibody drug delivery system through the inner and outer epidermis of the head and neck.

[0067] The collagen may be collagen peptide, collagen, or gelatin.

[0068] The collagen peptide used in this embodiment can be prepared by enzymatic hydrolysis of gelatin, donkey-hide gelatin, new donkey-hide gelatin, pig skin, cowhide, pig bone, beef bone, pig Achilles tendon or bovine Achilles tendon, and its relative molecular weight is not higher than 100kD.

[0069] The collagen used in this embodiment can be prepared by enzymatic hydrolysis of pig skin, cowhide, pig bone, beef bone, pig Achilles tendon or bovine Achilles tendon, and its relative molecular weight is 250-300 kD.

[0070] In the nanobody drug delivery system prepared in this embodiment through the inner and outer epidermis of the head and neck, the weight ratio of the active ingredient of the nanobody to ...

Embodiment 3

[0082] A nanobody drug delivery system through the inner and outer epidermis of the head and neck. The nanobody in the drug delivery system can eliminate IL-1 alpha (Interleukin 1 alpha) TNF-alpha, IL-8 (Interleukin 8) and other inflammatory factors .

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PUM

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Abstract

The invention discloses a drug administration preparation system for a nano-antibody through inner and outer cuticulae of a head and a neck as well as a preparation method and application of the drug administration preparation system. A carrier formula is optimized and the stability and tissue penetration of the nano-antibody are maintained and enhanced so that drug administration of nano-antibody biological medicines is realized through the outer cuticular layers of the head and the neck and inner cuticular layers of a nasal cavity. The drug administration preparation system can be used for treating a plurality of types of diseases of brain and central nervous systems by the specific nano-antibody, and can also be used for maintaining and keeping health of a brain nervous system of old people. The drug administration preparation system disclosed by the invention explores novel preparations of the nano-antibody biological medicines and a safe and effective central nervous system drug administration way.

Description

Technical field [0001] The present invention belongs to the technical field of medicine, and relates to a transdermal drug delivery system for specific nano antibodies, in particular a drug delivery system through the outer epidermal layer of the head and neck and the inner epidermal layer of the nasal cavity and a preparation method thereof, and the product is aimed at Disease treatment and maintenance of the brain and nervous system and health care applications. Background technique [0002] The blood-brain barrier (BBB) ​​is the barrier between the blood-brain barrier formed by brain capillary walls and glial cells between plasma and brain cells, and between the plasma formed by the choroid plexus and the cerebrospinal fluid. These barriers can prevent Certain substances enter the brain tissue from the blood. But because therapeutic drugs can also be blocked, the blood-brain barrier has become a major obstacle to the treatment of brain diseases. [0003] To exert the therapeut...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K39/395A61K39/44A61K47/42A61K47/32A61K47/34A61K47/38A61K47/64A61P29/00A61P31/12A61P31/04A61P35/00A61P25/28A61P25/16A61P25/06A61P11/02A61P17/00A61P25/00
CPCA61K39/39591A61K39/44A61K47/26A61K47/32A61K47/34A61K47/38A61K47/42A61K9/0014A61K9/0043C07K16/22C07K16/2863C07K16/32A61K2039/505C07K2317/569A61K47/36A61K47/10A61K47/24A61K2039/543A61K2039/54B82Y5/00
Inventor 李少平渠志灿
Owner NANOLATTIX BIOTECH CO LTD
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