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Cell scratch test cover

A cell scratching and experimenting technology, applied in biochemical instruments, biochemical equipment and methods, enzymology/microbiology devices, etc., can solve the error of the technique, the comparison experiment effect cannot be very accurate, and the width of the traces cannot be completely unified. and other problems, to achieve the effect of strong identity, convenient and simple production, and low cost

Active Publication Date: 2017-03-22
CHONGQING UNIVERSITY OF SCIENCE AND TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, conventional cell scratch experiments use the tip of the pipette to compare the ruler to complete the scratch of the cell. The pipette head must be vertical and cannot be tilted. Can not be completely unified, the effect of the comparative experiment cannot be very accurate

Method used

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  • Cell scratch test cover
  • Cell scratch test cover
  • Cell scratch test cover

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] refer to Figure 1 to Figure 5 The shape and structure of a cell scratch experiment cover and its use method. The specification of the scratch cover 1 is: the maximum length, which is equivalent to the long side of the scratch cover 1 cuboid with arc-shaped diameter ϕ=100mm at both ends, and there are 2 pieces The sliding rail grooves 13 parallel to each other are suitable for cell culture dishes with a diameter of ϕ100mm. Use a scratching needle 4 with a diameter of ϕ=2mm.

Embodiment 2

[0018] refer to Figure 1 to Figure 5 The shape and structure of a cell scratch experiment cover and its use method. The specification of the scratch cover 1 is: the maximum length, which is equivalent to the long side of the scratch cover 1 cuboid with arc-shaped diameter ϕ=60mm at both ends, and there are 2 pieces The sliding rail grooves 13 parallel to each other are suitable for cell culture dishes with a diameter of ϕ60mm. Scratch needle 4 with diameter ϕ=1.5mm.

Embodiment 3

[0020] refer to Figure 1 to Figure 5 The shape and structure of a cell scratch experiment cover and its use method. The specification of the scratch cover 1 is: the maximum length, which is equivalent to the long side of the scratch cover 1 cuboid with arc-shaped diameter ϕ=35mm at both ends. The sliding rail grooves 13 parallel to each other are suitable for cell culture dishes with a diameter of ϕ35mm. Scratch needle 4 with diameter ϕ=1mm.

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Abstract

The invention provides a cell scratch test cover. The cell scratch test cover is characterized by mainly comprising a main cover and a movable clamping cover. The scratch cover is a bridge-like cover of a rectangular solid shape, no cover edge is arranged on the two longer sides of the rectangular solid, and circular cover edges are arranged at both ends of the longer sides of the rectangular solid to be buckled on the circular outer side wall of a cell culture dish. The main cover comprises the cover edge at one end of the scratch cover and the rectangular solid cover, and the cover edge at the other end of the scratch cover is the independently separated movable clamping cover. The end surface of the main cover of the scratch cover and the movable clamping cover are tightly attached to each other under the effect of an elastic tensioning device in case of no external force. The cell scratch test cover has the technical characteristics of convenient and simple manufacturing, low cost, high scratch identity, more precise contrast experiment data and simple and convenient operation.

Description

technical field [0001] The invention relates to a small device for cell experiments, in terms of use, it is a cell scratch cover for cell growth and migration experiments in bioengineering and medicine. Background technique [0002] Tumor tissue, uncontrolled proliferation of cancer tissue, abnormal differentiation of tumor cells, and the ability of tumor cells to invade and metastasize are the most basic biological characteristics of malignant tumors, and invasion and metastasis are the main reasons why malignant tumors threaten the health and even life of patients. Therefore, it is of great significance to study the law of tumor invasion and metastasis and its mechanism for the prevention and treatment of malignant tumors. The cell scratch method is one of the methods to measure the motility characteristics of tumor cells. It draws on the uncontrolled proliferation of tumor tissue, abnormal differentiation of tumor cells, and the ability of tumor and cancer cells to invad...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12M1/00
CPCC12M23/10C12M23/38C12M41/46
Inventor 廖晓玲徐文峰杨晓玲
Owner CHONGQING UNIVERSITY OF SCIENCE AND TECHNOLOGY