Synthetic method for medical material, 4-bromine-2-methyl-3,6-dihydroxypyrimidine
A technology of dihydroxypyrimidine and synthesis method, which is applied in the field of synthesis of medical body 4-bromo-2-methyl-3,6-dihydroxypyrimidine, can solve problems such as the synthesis method of unreported compounds, and achieves a simple synthesis method , the effect of safe operation
Inactive Publication Date: 2017-03-29
WUXI QIANHAO BIOPHARMA
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Problems solved by technology
[0002] The synthesis method of 4-bromo-2-methyl-3,6-dihydroxypyrimidine is the starting material for the synthesis of many drugs, especially the important intermediates of many hydroxypyrimidines. At present, there is no report on the synthesis method of this compound in China
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[0008] The synthetic method of medical substance 4-bromo-2-methyl-3,6-dihydroxypyrimidine of the present invention is specifically as follows:
[0009] Using 4-bromopyrimidine as a raw material, under the action of solvent acetone and PH6-7, at a temperature of 100°C-140°C, it undergoes methylation and hydroxylation successively to generate 4-bromo-2-methyl-3,6- Synthetic method of dihydroxypyrimidine. The purity of this crude product can meet the general reaction requirements and can be directly put into the reaction.
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The invention relates to a synthetic method for medical material, 4-bromine-2-methyl-3,6-dihydroxypyrimidine. According to the synthetic method, by taking 4-bromopyrimidine as a raw material, the 4-bromine-2-methyl-3,6-dihydroxypyrimidine is generated via methylation and hydroxylation in sequence at the temperature of 100 DEG C-140 DEG C and the PH value of 6-7 under the action of solvent, acetone. The synthetic method for the medical material, 4-bromine-2-methyl-3,6-dihydroxypyrimidine, provided by the invention is very simple and efficient, safe in operation, and very practical in concrete production.
Description
technical field [0001] The invention relates to a method for synthesizing medical substance 4-bromo-2-methyl-3,6-dihydroxypyrimidine. Background technique [0002] The synthesis method of 4-bromo-2-methyl-3,6-dihydroxypyrimidine is the starting material for the synthesis of many drugs, especially the important intermediate of many hydroxypyrimidines. There is no report on the synthesis method of this compound in China. Contents of the invention [0003] The object of the present invention is to overcome the above disadvantages, and provide a simple, efficient and safe synthesis method of medical substance 4-bromo-2-methyl-3,6-dihydroxypyrimidine. [0004] The purpose of the present invention is achieved like this: [0005] A method for synthesizing medical substance 4-bromo-2-methyl-3,6-dihydroxypyrimidine, using 4-bromopyrimidine as a raw material, under the action of solvent acetone and PH6-7, at a temperature of 100°C-140°C The following is a synthetic method for gene...
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Login to View More IPC IPC(8): C07D239/52
CPCC07D239/52
Inventor 彭海燕
Owner WUXI QIANHAO BIOPHARMA
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